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  1. Licensing and Collaboration Opportunities

FDA Technologies Available for Licensing and Collaboration

Title E # Product Area Research Area Technologies & Applications Development Stage FY Keywords
Stable cell line for validating next-generation sequencing (NGS) methods for detecting adventitious viruses contaminating biological products E-2023-001 Biologics testing and manufacturing including but not limited to viral vaccines, biotherapeutics, and cellular and gene therapy products Cell Line Therapeutics, Biologics In vitro data available 2023 A549, adventitious, assay, biological material, biologics, biologics testing, biotherapeutics, cell line, cellular therapeutics, gene therapy, latent virus, next-generation sequencing, NGS, reference standard, simian foamy virus, validation, viral vaccines, virus
Identification and elimination of helper and cytotoxic T cell epitopes in AAV9 E-2022-010 Gene Therapy, Immunology Research, Assay Development Gene Therapy, Diagnostic Gene Therapy, Research Tool, Diagnostic In vitro data available 2022 Helper T Cells, Cytotoxic T Cells, AAV9, Gene Therapy, Immunogenicity, AVV vectors, CD4, CD8, T Cells, Gene Delivery
Live attenuated Sars-CoV-2 vaccine candidate adaptable to emerging SARS-CoV-2 variants E-2022-007 Vaccine development, candidate SARS-CoV-2 vaccine Vaccine Development Research Tool, Vaccine and Diagnostic Development Proof-of-concept, vaccine challenge studies in transgenic mice and in Syrian hamsters, and vaccine candidate 2022 COVID, COVID-19, Wang, live attenuated virus, Omicron, Delta, Wuhan-1, vaccine, vaccine development, SARS, SARS-CoV-2
Computationally Engineered Anti-Sars-Cov-2 Monoclonal Antibodies with High Binding Affinities E-2022-006

Research tools, diagnostic assays, vaccine development, therapeutic antibodies

Vaccine Development, Diagnostics, Therapeutics  Vaccine Development, Diagnostics, Therapeutics  Monoclonal antibodies, expression plasmids, and in vitro characterization data 2022 SARS, SARS-CoV-2, SARS-CoV-1, monoclonal, antibodies, research tool, diagnostic, Sauna
Magnetic Resonance Spectra (MRS) Processing Software for Accurate Analysis E-2022-005 Software, medical diagnostic, research tool Medical Devices, Diagnostics Medical Devices, Diagnostics, MRI, MRS Proof-of-concept 2022 MRI, MRS, medical imaging, medical device, software, Buzatu
Modified Factor Xa Polypeptides to Recover Clotting Activity in Subjects Treated with Direct Oral Anticoagulants (DOACs) E-2022-003 Biologics, Direct Acting Anticoagulants, DOACs, Thromboembolic Disease, Bleeding Disorders Therapeutics, Biologics Therapeutics, Biologics Proof-of-concept, In vivo animal data 2022 biologic, bleeding disorders, blood clots, clotting, direct oral anticoagulants, DOACs, factor Xa, Sauna, Thromboembolic Disease
System and method for in vivo estimation of brain amyloid burden using X-rays E-2022-001

Diagnostic imaging, neuroscience

Medical Devices, Diagnostics Medical Devices, Diagnostics, Imaging prototype, proof of concept studies 2022 brain, amyloid plaque, X-rays, neurodegenerative disease, Alzheimer's, Parkinson's, PET, positron emission tomography, MRI, magnet resonance imaging
Lac operator-based mitigation of heterologous DNA instability in plasmids propagated in E. coli E-2021-019 Therapeutics, vaccine, biologics Therapeutics, Bioprocessing Therapeutics, Biologics, Protein, Production, Bioprocessing In vitro data available 2021 Plasmid, DNA, Gene Expression, E. coli, biopharmaceutical, toxic gene, Lac Repressor, Influenza, Flu, Hemagglutinin, Neuraminidase, Reverse Genetics, viral protein, protein, vaccine, biologics, eukaryotic
Stable Non-infectious Cell Clones that Produce Functional SARS-CoV-2 RNA for Nonstructural Proteins and Accessory Proteins E-2021-017 Screening Tool, COVID-19, SARS-CoV-2, Antiviral Drugs, Screening Viral Infectious Diseases SARS-CoV-2 replication, screening compounds Proof-of-concept for screening compounds, Research Tool 2021 Wang, Liu, SARS-CoV-2, COVID-19, cell clones, nonstructural proteins, accessory proteins
Chimeric immunotoxins targeting IL-13Ralpha2 positive human cancers E-2021-010 protein therapeutic, cancer, biologic, oncology Oncology protein therapeutic, cancer, biologic, oncology In vivo animal data 2021 IL-13, IL-13R, cancer, head and neck cancer, prostate cancer, colorectal cancer, breast cancer, stomach cancer, cervical cancer, oncology, protein, chimeric, Pancreatic ductal adenocarcinoma, PDAC
Live Attenuated Rubella Vector to Express Vaccine Antigens E-2012-003 Research materials, tool, gene manipulation Vaccine Development Research Tool, HIV and Bivalent Rubella Vaccine Development Pre-clinical, in vitro data available, in vivo data available (animal) 2012 Berkower, Virmik, HIV, rubella, SIV, SHIV, P150, vaccine, antigen
Adaptive Perfusion: A Novel In Vitro Release Test (IVRT) Method for Complex Drug Products E-2020-025 drug development, drug formulations, drug manufacturing, drug production, quality control, drug delivery  Drug development, drug manufacturing, quality control Drug development, drug manufacturing, quality control, tangential flow filtration (TFF) In vitro data, prototype 2020 Drug in vitro release testing, IVRT, drug dissolution testing, tangential flow filtration, formulation, drug development, quality control, emulsions, micelles, suspensions, liposomes, drug-protein complex
Chimeric antigen receptor (CAR)-T cells targeting IL-13Ralpha2 positive human solid cancers E-2020-020 CAR-T, Cellular therapeutics, cancer, biologic, oncology, solid tumors CAR-T, Cellular therapeutics, cancer, biologic, oncology, solid tumors CAR-T, Cellular therapeutics, cancer, biologic, oncology, solid tumors In vivo animal data 2020 Chimeric antigen receptor T cell, CAR-T, cancer, solid tumors, cellular therapeutics, IL-13, IL-13R
Coronavirus sars cov-2, sars cov antigens, and rabbit polyclonal antibodies E-2020-016 Biologics Viral Infectious Diseases Vaccines Research Materials 2020 Antibody, rabbit, coronavirus, SARS, antigen, sera, vaccine development, Khurana
A Novel Solid Support for Efficient Reduction of Process-Related Impurities in Synthetic Nucleic Acid Sequences E-2020-015 CPG support, nucleic acid-based drugs, solid-phase DNA/RNA synthesis Synthetic nucleic acid synthesis Purification of synthetic nucleic acid sequences Proof of concept system 2020 DNA, RNA, Beaucage, Grajkowski
Mouse Monoclonal Antibodies Specific to Trypanosoma Cruzi Antigens E-2020-014 Research materials, monoclonal antibodies, Trypanosoma cruzi, Chagas Chagas Disease Research Tool, Diagnostic Test for Chagas Disease, Antigen testing to confirm disease status Development assays to detect T. cruzi in mice and Chagas patients 2020 Chagas, T. cruzi, monoclonal antibodies, trypanosoma, Debrabant, Nagarkatti, Acosta
Hepg2-Fluc-Gluc and Hepg2-Fluc-Seap Cell Lines E-2020-010 Research Materials, Cell Line, In Vitro System Cell line Drug evaluations for drug-induced liver injury Research Tool 2020 Cell Line, Liver Injury, Endoplasmic Reticulom, Gaussia Luciferase, Guo, Chen
Hybridomas for Monoclonal Antibodies Specific to Fragment B, Fragment C, and Light Chain of Tetanus Toxin E-2020-002 Research Materials, Antibody, Vaccine Vaccine In-vitro diagnostics, tetanus toxin and fragments research and development Research Materials 2020 Tetanus, fragment C, antibodies, vaccine, tetani, Shapiro, Kenimer, Habig, Fitzsimmons, Hardegree
Cross-Protective Norovirus Epitope and Monoclonal Antibodies E-2019-025, E-2019-026 antigenic variation, caliciviruses, evolution, gastrointestinal, infection, norovirus, phylogenetic, virus, antibodies, neutralizing, epitope, method, peptide, monotypic, interfere, sequence, amino acid, binding, inhibiting, gene, genomics Antiviral, virus, norovirus, diagnostic, assay development diagnostic, assay development In vitro data 2019 antigenic variation, caliciviruses, evolution, gastrointestinal, infection, norovirus, phylogenetic, virus, antibodies, neutralizing, epitope, method, peptide, monotypic, interfere, sequence, amino acid, binding, inhibiting, gene, genomics
Lentiviral vectors bearing il-13 that Target Human IL-13 Receptor alpha-2-Positive TUMOR Cells E-2019-024 Biologics Oncology, basic research, Lentivirals Bioassay, Diagnostics, Vaccine Research Materials 2019 Lentiviral vector, IL-13, IL-13R
An Attenuated Live Mumps Virus Vaccine Candidate Expressing F and HN Protein Genes from Genotype G E-2018-022 Biologics Viral Infectious Disease Vaccines In vivo
animal data
2018 mumps, vaccine, immunity, disease, meningitis, virus, plasmid, strains, Rubin, gene, Jeryl Lynn, protein, genotype, recombinant, combination
Efficient Storage Algorithm for Time-Domain Spectrum Measurement E-2018-016 Algorithm, Software wireless signaling, data compression High-capacity storage of spectrum survey in a hospitals and healthcare systems Validated on National Instruments (NI) vector signal transceiver platform in a healthcare environment 2018 Bluetooth, frequency, wireless, signal, storage, hospital, medical, device, spectrum, time-domain, platform, method, interference, data compression
Hybridomas Secreting Novel Monoclonal Antibodies Against the Nucleoprotein of Influenza Virus E-2018-007 Biologics Viral Infectious Disease Bioassay, Diagnostics, Vaccine Research Material 2018 Influenza, Antibody, Vaccine, Diagnotic, Hongquan Wan
Enhanced Chemiluminescent Enzyme-Linked Immunosorbent Assay for Detection of Antibodies Against Babesia Microti E-2017-031 Diagnostic, Screening Tool, Babesia microti Parasitic Infectious Diseases Babesia testing in donor blood Early development 2017 Kumar, Verma, Babesia, Babesiosis
Synergistic Antitumor Activity of Combination Immunotherapy IL-4 receptor targeted agents and Interferons -alpha and -gamma E-2017-025 Drugs, Oncology Oncology Biologic therapeutic in vivo animal studies 2017 IL-4, interferon, puri, synergistic, ovarian, cancer, chimeric protein, pseudomonas exotoxin, IFNgamma, anti-interleukin, anti-interleukin-4, Husain, GrSynergistic Antitumor Activity of Combination Immunotherapy IL-4 receptor targeted agents and Interferons -alpha and -gamma ​
Reassortant Influenza Viruses Expressing Neuraminidase (NA) And A Mismatched Hemagglutinin (HA) Protein Useful for Determining Antibody Titers of Functional Na-Specific Antibodies E-2017-022 Biologics Viral Infectious Diseases Vaccines, Diagnostics, Therapeutics In vitro data, Research Material 2017 Influenza, neuraminidase, HA, Hemagglutinin, virus
Listeria Monocytogene Strains Containing Antibiotic Resistance and Green-Flourescent Protein Markers E-2017-020 Biologics Bacterial Infectious Diseases, Food Safety Vaccines, quality control, proficiency testing materials, test kits, Diagnostics, assay validation, Monitoring Research Material 2017 listeria, monocytogenes, pathogen, celery, contaminant, chicken, vaccine development, Datta, Sahu, Burall
Biological Classifier and Clustering Methods for High-Dimensional, Multivariate Measurement Data Sets Using the Grand Canonical Monte Carlo Ensemble E-2017-017 Bioinformatic, software, genomics Software, bioinformatics, genomics Software, bioinformatics, genomics Software 2017 Software, bioinformatics, genomics, Monte Carlo Ensemble
Serum-Free Medium for the Isolation and Expansion of Canine Adipose-Derived Mesenchymal Stem/Stromal Cells E-2017-010 Research material, Supplement, Media, Serum Stem cell, Stromal Cell In-vitro diagnostics, tetanus toxin and fragments research and development Research Material 2017 Mesenchymal Stem/Stromal Cells (MSCs), fetal bovine serum (FBS), Devireddy, Screven
Gonoccoccal Vaccine/Therapy from Neisseria meningitidis E-2017-006 Biologics Viral infectious Diseases, bacterial infectious diseases Vaccines, Drug Design In vivo animal studies 2017 meningitis, meningitidis, Neisseria meningitidis, vaccine, N. meningitidis, N. gonorrhoeae
Factor H Binding Protein-Choleratoxin B Chimeric Vaccine Construct Against Neisseria Meningoccal Disease E-2017-003 vaccine development, adjuvant Bacterial Infectious Diseases Vaccine development for group N. meningitidis serogroup B strains Early Proof of concept studies completed 2017 Neisseria Meningoccal, meningitidis, FHbp, choleratoxin, Bash, Price, Lee
Genetically Engineered Mouse Model Used as an Alternative Screening Method for Evaluating P-Glycoprotein Substrate Toxicity in Avermectin-Sensitive Dogs E-2011-026 Research materials, mouse model Drug Safety Drug screening technology to assess the toxicity of canine drugs to canines with the mutated form of the ABCB1 gene. In vitro data available 2011 Yancy, ABCB1, avermectin, Ivermectin, canine, herding dogs
Flow Cytometry-Based Systems and Methods for Detecting Microbes E-2011-022 Foodborne illnesses, food safety, flow cytometer, microbial contamination Foodborne illnesses, food safety, flow cytometer, microbial contamination Foodborne illnesses, food safety, flow cytometer, microbial contamination In vitro data, prototype 2011 foodborne illnesses, flow cytometry, microbial contamination, bacteria, virus, protozoa, prion, food safety
Pooled Human Complement Meningococcal Bactericidal Activity Assay E-2014-008 Method, immunoassay, vaccine development, assay development Vaccine Human bioassay development Proof-of-concept 2014 Bash, Lynn, meningococcal, serogroup A
Neisseria Meningitidis A, C, W-135, X, Y Serogroups E-2013-017, E-2013-018, E-2013-019, E-2013-020, E-2013-021 Research Materials, vaccine, diagnostic Vaccine Development Research Tool, Vaccine and Diagnostic Development  Research material 2013 Vann, Che-Hung, meningococcal, Neisseria meningitidis
Anthrax Lethal Toxin Inhibits Proliferation of Human CD4+ t cells in Response to t cell Receptor Stimulation and Mitogen Stimulation
E-2004-039 anthrax bioassay, diagnostic, bioterrorism Viral Infectious Diseases Human bioassay development Early proof-of-concept 2004 Bacillus anthracis, anthrax, Frucht, Fang, bioterrorism, bioassay
Improved Method of Allelic Exchange  E-2015-003  Research materials, tool, gene, manipulation Genetic alteration, allelic replacement Simplified genetic manipulation without use of selectable markers Research Materials 2015 Bordetella, Pertussis, parapertussis, bronchiseptica, Allelic, Stibitz
Software for 3D Spectral Fingerprint based consensus modeling using orthogonal pls and tanimoto similarity KNN techniques E-2014-001 Software Molecular modeling, spectoral modeling Drug design, drug development, software, research tool   2014 Research tool, software, bioinformatics, modeling, Slavov, Berger, Buzatu, Pearce
Inactivation of Pathogens in Blood Products Using Visible Light E-2014-013 Antimicrobials, bacterial, infectious disease Blood pathogen reduction Blood Products, Pathogen Reduction, Infectious Disease, Antimicrobials prototype, proof of concept 2014

Antimicrobials, bacterial, infectious disease, blood products, pathogen reduction, Atreya, Maclean, Anderson, MacGregor

Anti-Influenza A Neuraminidase monoclonal antibodies E-2015-001, E-2013-008, E-2019-012 Animal & Veterinary Research material, viral infectious diseases Bioassays Research material 2015

Influenza, influenza virus, monoclonal antibody, neuraminidase, CD6, immunoassay, anti-neuraminidase, neuraminidase 1 (N1), neuraminidase 2 (N2), neuraminidase 9 (N9), research tools, diagnostic assays, vaccine development

Nonpathogenic Bacteria, Paenibacillus alvei, Useful As a Natural Biocontrol Agent for Elimination of Food-Borne Pathogenic Bacteria E-2014-007 Drugs Bacterial Infectious Disease, Antimicrobial Therapeutics, drug design in vitro 2014 antimicrobial, peptides, bacterial, infectious disease, salmonela, paenibacillus alvei, bactericide
Hemoglobin-Polymer Phantoms for Biophotonic Device Performance Evaluation E-2016-002 Devices Medical Devices Imaging, Medical device
Prototype 2016 hemoglobin polymer phantoms, biophotonic, device, imaging systems
Tissue-mimicking polymer test phantoms for optical-acoustic medical imaging. E-2016-003 Devices   Imaging, Medical Device Prototype 2016 Photoacoustic, imaging, phantom, optical, acoustic, tunable, magnetic, tomography, diagnostic, sound, pfefer, tissue, mimic
Anti-influenza Monoclonal Antibodies to Hemagglutinin (HA) That Are Suitable for Identification and Quantification of Seasonal Influenza Vaccines E-2016-004 Biologics Viral Infectious Diseases Bioassay, Diagnostics, Vaccine In vitro data 2016 influenza, monoclonal, antibodies, glycoprotein, strain, epidemic, hemagglutinin, protein, pandemic, virus, vaccine, weir, H1N1, vaccination, diagnostic, assay
Solid-phase Purification of Synthetic DNA Sequences E-2016-005 Drugs Chemicals, Pesticides, & Metals Cellular and gene therapy, therapeutics, drug delivery In vitro data 2016 solid-phase, purification, synthetic, DNA, sequence, high-throughput, method, design, purity, technique, nucleotide, manufacture, beaucage
Therapeutic and Prophylactic Anti-Influenza Virus Neuraminidase 1 (N1) Antibody (Cd6) With a Novel Epitope That Spans Neuraminidase (Na) Dimers E-2015-001 Biologics Viral Infectious Disease Vaccines, Diagnostics, Bioassays

in vitro and in vivo

2015 CD6, neutralizing antibody, neuraminidase, hemegglutinin, influenza virus, viral
Use of Nonpathogenic Bacteria, Paenibacillus Alvei, as a Natural Biocontrol Agent for Elimination of Food-Borne Pathogenic Bacteria E-2011-003 Food Food Safety, Chemicals, Pesticides, & Metals Therapeutics, drug design Pre-development 2011 TS-15, food, borne, pathogens, Salmonella, Escherichia, Listeria, Shigella, Enterobacter, Staphylococcus, food supply, biocontrol, agent, pesticide, fruits, vegetable, food-borne, pathogen, antibiotic, resistant, Agriculture, Brown, Zhang
Nanoparticulate Complex of Nicotine and Cerium Oxide for the Treatment of Parkinson’s Disease E-2014-002 Drugs Neuroscience & Pain Nanotechnology In vitro data 2014 tobacco, Parkinson's, nicotine, conjugate, nanoceria, anti-oxidant, oxidant, neuronal, Imam
Vaccine for Protection Against Shigella sonnei Disease E-2001-016 Biologics Bacterial Infectious Diseases Vaccines, Diagnostics In vivo animal data 2001 Shigellosis, food, water, bacterium, Shigella, sonnei, antibiotics, resistant, vaccine, Shigellae, polysaccharide, immunoprotective, vaccine, mice, Shigella, Typhoid, Kopecko, Xu, Cisar
Typhoid-Plague Bivalent Vaccine E-2011-007 Biologics Bacterial Infectious Diseases Vaccines, Diagnostics, Therapeutics   2011 Yersinia, pestis, plague, flea, lungs, pneumonic, bioterrorist, vaccine, oral, construct, fusion, attenuated, typhoid, fever, bacterial, immune, anthrax, delivery, therapeutics, diagnostics, Vector, Kopecko, Osorio, Foote
A Novel Anthrax Vaccine Candidate E-2003-032 Biologics Bacterial Infectious Diseases Vaccines, Diagnostics, Therapeutics In vivo animal data 2003 vaccine, anthrax, injectable, anthracis, Escherichia, coli, alpha, hemolysin, typhoid, Salmonella, enterica, serovar, Typhi, Immunization, mice, serum, immunoglobulin, toxin, neutralizing, Vaccinated, intranasal, aerosolized, spores, Anthrax, Kopecko, Osorio, Giri, Blake, Bhattacharyya
Live Oral Shigella dysenteriae Vaccine E-2004-022 Biologics Bacterial Infectious Diseases, Food Safety Vaccines, Diagnostics, Therapeutics in vivo 2004 Salmonella, typhi, construct, Shigella, dysenteriae, polysaccharide, Ty21a, constructs, immune, dysentery, serotypes, dysentery, shigellosis, Kopecko, Xu
Oral Shigellosis Vaccine E-2012-016 Biologics Bacterial Infectious Diseases, Food Safety Vaccines, Diagnostics, Therapeutics   2012 Salmonella, typhi, Shigella, sonnei, biosynthetic, constructs, immune, antigenic, bacterial, Bacillary, dysentery, enteric, fever, dysentery, vaccine, resistance, multivalent, Shigellosis, Dharmasena, Kopecko
Synthetic Peptides with Antimicrobial Activity E-2012-023 Biologics Bacterial Infectious Diseases Therapeutics, Diagnostics In vitro data 2012 synthetic, peptides, antimicrobial, E., coli, aeruginosa, S. aureus, S. epidermidis, B. cereus, K. pneumonia, platelets, plasma, cytotoxic, blood, toxicity, drug, development, resistant, bacterial, antimicrobial, Atreya, Rao, Ketha
Respiratory Syncytial Virus (RSV) Vaccine Candidates from RSV Glycoprotein (G) and Fusion (F) Protein E-2013-016,
Biologics Viral Infectious Diseases Vaccines In vitro data 2013, 2015, 2018 cross, neutralizing, vaccine, human, respiratory, syncytial, viru, immunogenic, recombinant, vaccines, immunogenicity, Khurana, Golding
Software for Evaluating Drug Induced Hepatotoxicity E-2012-008 Software Hepatology, drug interactions Drug interactions, software, research tool   2014 hepatotoxicity, Guo, SAS, Research tool, software, liver
Use of Cysteamine to Treat Metastatic Cancer E-2013-010 Drugs Oncology, Neuroscience & Pain Therapeutics In vivo animal data 2013 Cysteamine, aminothiol, anti-oxidant, radiation, neurological, cancer, matrix, metalloproteinases, MMP, tumor, metastasis, metastasis, xenograft, umor, mice, therapeutic, Puri, Joshi
Therapeutic Hepatitis C Virus Antibodies E-2012-002 Biologics Viral Infectious Diseases, Hepatology Therapeutics In vitro data 2012 Therapeutic, antibodies, Hepatitis, Virus, HCV, interfering, neutralizing, infection, monoclonal, liver, transplants, Feinstone, Duan, Major, Zhang, Kachko
Multivalent Meningiococcal Conjugates and Methods for Preparing Conjugates E-2012-005 Biologics Bacterial Infectious Diseases Vaccines   2012 meningococcal, polysaccharide, vaccines, tetravalent, PS, tetravalent, conjugate, meningococcal, Neisseria, meningitidis, immunogen, vaccine, autoimmune, immunogenic, conjugates, polysaccharide, Neisserial, Lee, Pinto
Nanoparticle Probes and Mid-Infrared Chemical Imaging for DNA Microarray Detection E-2010-015 Biologics, Food Environmental Science Imaging, Nanotechnology, Diagnostics, Biomarkers   2010 microarray, visualization, infrared, chemical, imaging, IRCI, nanostructure, DNA, microarray, gene, expression, single, nucleotide, polymorphisms, SNPs, genome, signal-to-noise, SNR, hybridized, microarrayed, fluorescence, pathogenic, fluorescent, microarrays, protein, tissue, biochemical, chemical, toxicogenomics, microarray, Mossoba, Al-Khaldi, Schoen
Filovirus Vaccines and Diagnostics Based on Glycoprotein-Fc Fusion Proteins E-2010-018 Biologics Viral Infectious Diseases Vaccines, Diagnostics In vivo animal data 2010 Ebola, virus, Filoviridae, bioterrorism, hemorrhagic, fever, primates, Filovirus, subunit, vaccine, extracellular, glycoprotein, immunoglobulin, humoral, cellular, immunity, Vesicular, Stomatitis, Virus, response, Vaccine, virus-like particles, Kaplan, Konduru, Bavari, Bradfute
Purified Saxitoxin for Food Safety Applications E-2009-010 Food Natural Toxins, Food Safety Biomarkers, Bioassays   2009 Saxitoxin, toxins, seafood, food, borne, illness, Monitoring, contamination, Detection, poisons, Hall
Peptides for HIV-1 Infection Detection Assay for Seroconverted HIV-1 Vaccine Recipients E-2004-030 Biologics Viral Infectious Diseases Bioassays   2004  
Highly Adaptable Internal Control Nucleic Acid Molecule for Real-Time Polymerase Chain Reaction E-2003-016 Biologics, Food, Devices Diagnostics, Bioassays Diagnostics, Bioassays   2003 PCR, internal, control, system, real, time, PCR, kinetic, Q-PCR, conventional, assay, Vickery, DePaola, Blackstone
Direct Impact Spark Ionization (DISI) Mass Spectrometry (MS) for Identification of Microbes E-2011-021 Devices Food Safety, Environmental Science Monitoring, Biodefense   2011 mass, spectrometry, device, direct, impact, spark, ionization, microbial, analytes, identification, pectral, pattern, recognition, microbiological, pathogen, determination, drugs, food, cosmetic, ingredients, monitoring, airborne, Biological, Warfare, Agents, Pathogen, bacterial, Wilkes, Alusta, Dorey, Parker, Buzatu
Bacterially Expressed Influenza Virus Recombinant HA Proteins for Vaccine and Diagnostic Applications E-2010-004 Biologics Viral Infectious Diseases Vaccines, Diagnostics   2010 H1N1, influenza, virus, Avian, pandemic, chicken, egg, HA, H1N1, H5N1, neutralizing, antibody, in vivo, animal , models, vaccine, diagnostic, Golding, Khurana
Novel Methods for the Reversible Incorporation of Functional Groups into RNA and DNA: Synthesis and Uses for 2'-O-aminooxymethyl Nucleoside Derivatives E-2010-019 Drugs, Biologics   Diagnostics, Cellular & Gene Therapy, Drug Delivery, Small Molecule Therapeutics, Drug Design   2010 DNA, RNA, therapeutic, drugs, silencing, expression, genes, interference, synthetic, synthesis, oligonucleotides, diagnostic, therapeutic, Beaucage, Cieslak
Meningococcal and Pneumococcal Conjugate Vaccine and Method of Using Same E-2010-002 Biologics Bacterial Infectious Diseases Vaccines   2010 Pneumococcal, Streptococcus, pneumoniae, pneumonia, meningitis, febrile, bacteremia, otitis, media, sinusitis, bronchitis, Vaccination, microbial resistance, bacterial, meningococcus, Neisseria, meningitidis, respiratory, meningeal, septic, pneumonia, meningitis, vaccine, pathogen, conjugate, vaccines, recombinant, Lee
System for Magnetic Resonance Spectroscopy of Brain Tissue for Pattern-based Diagnostics E-2009-011 Devices Neuroscience & Pain Medical Devices, Imaging   2009 Magnetic, resonance, spectroscopy, MRS, Brain, Tissue, Pattern, Based, Diagnostic, Preprocessing, Module, Spectrum, Normalize, Scan, Raw, MRI, Brain, Imaging, Neurology, Wilkes, Buzatu, Alusta, Pearce, Kretzer, Im, Beger
Insertion of Foreign Genes in Rubella Virus and their Stable Expression in a Live, Attenuated Viral Vaccine E-2008-011 Biologics Viral Infectious Diseases Vaccines   2008 Rubella, virus, RUB, Rubivirus, Togaviridae, genes, vector, live, vaccine, HIV, vector, expression, Berkower, Spadaccini
A Hand Held Portable Device Based on LEDS for Use in The Detection of Counterfeit Pharmaceutical Drugs and Packaging E-2008-017 Devices, Drugs   Post-Market Surveillance, Monitoring Prototype 2008 hand, held, portable, device, detection, counterfeited, pharmaceutical, prototype, light, emitting, diode, LED, Testing, authenticity, Ranieri
Novel Oligonucleotides for Treatment of Human Cancer E-2008-007 Drugs, Biologics Oncology Therapeutics, Cellular & Gene Therapy   2008 Human, endogenous, retroviruses, HERV, antisense, sense, oligonucleotides, RNA, ERV-9, LTR, cancer, breast, liver, prostate, myeloid, fibrosarcoma, therapeutic, tumor, siRNA, gene, expression, Therapeutic, Xu, Rosenberg, Elkahloun, Candotti
Controlled Formation of CpG Oligonucleotide Multimers E-2004-024 Drugs, Biologics Adjuvants; Vaccines; Oligonucleotide Therapeutics Drug design; Cellular and gene therapies; Molecule delivery in vitro data; in vivo data; preclinical primate studies 2004 CpG, oligonucleotides, oligonucleotide, prodrug, Therapeutic, immune, immunostimulatory, Verthelyi, Beaucage, Grajkowski
Use of Sterically Stabilized Cationic Liposomes to Efficiently Deliver CpG Oligonucleotides in vivo E-2001-020 Drugs Immunotherapy Drug Delivery, Drug Design, Cellular & Gene Therapy In vitro data, In vivo animal data 2001 Immunostimulatory, CpG, oligonucleotide, ODN, immune, adjuvant, anti-allergens, Sterically, Stabilized, Cationic, Liposomes, SSCL, in vivo, in vitro, mice, L. monocytogenes, listeria, Klinman, Gursel
Identification of DNA Sequence Motifs that Suppress the Immune Response to CpG DNA E-2001-021 Drugs Immunotherapy Cellular & Gene Therapy   2001 CpG, oligonucleotide, immunostimulatory, oligodeoxynucleotides, ODN, septic, shock, adult, respiratory, distress, syndrome, ARDS, autoimmune, disease, suppressive, vaccine, therapeutic, Klinman, Gursel
Monoclonal Antibodies to Fusion-Active Conformations of HIV-gp41 E-2007-011 Biologics Viral Infectious Diseases Bioassays, Therapeutics   2007 monoclonal, HIV, gp41, tool, screening, antiretroviral, Research, Weiss, Vassell
Diagnostic Targets and Potential Vaccine Against H5N1 Avian Influenza E-2007-026 Biologics Viral Infectious Diseases Therapeutics, Vaccines in vivo studies 2007 peptide, polypeptide, influenza, virus , immunogenic, neutralizing, antibodies, avian, H1N1, H3N2, H5N1, H7N7, immunogenic, adjuvant, vaccine, Diagnostic, Golding, Khurana
Oligodeoxynucleotide and Its Use To Induce an Immune Response E-1999-009 Biologics Oncology, Immunotherapy Cellular & Gene Therapy, Vaccines   1999 oligodeoxynucleotides, ODN, CpG, immunostimulatory, immune, production, T cell, therapeutic, cancer, vaccine, adjuvant, autoimmune, disorders, immune, deficiencies, anti-infective, antisense, therapy, Klinman, Verthelyi, Ishii, Gursel
Neutralization of Hepatitis C Virus (HCV) E-2007-028   Viral Infectious Diseases Therapeutics   2007  
Improved Immunotherapeutic Compositions for Treatment, Diagnosis and Prevention of HIV E-2008-027 Biologics Viral Infectious Diseases Therapeutics, Vaccines, Diagnostics   2008 HIV, vaccine, neutralizing, antibodies, glycoprotein, immune, immunization, gp120, immunogen, polypeptide, virus-like, particles, TLR, therapeutics, diagnostics, Berkower
Mouse Monoclonal Antibody Targeting Tetanus Toxin Heavy Chain Fragment C E-2009-003 Biologics Bacterial Infectious Diseases, Natural Toxins Therapeutics   2009 murine, monoclonal, antibody, tetanus, toxin, neurotoxin, neuron, botulinum, antitoxins, Shapiro, Fitzsimmons
Membrane Proximal Region of HIV gp41 Anchored to the Lipid Layer of a Virus-Like Particle Vaccine E-2008-026 Biologics Viral Infectious Diseases Therapeutics, Vaccines, Diagnostics   2008 HIV, envelope, glycoprotein, gp120, gp41, immunogenic, antibodies, immune, membrane, proximal, region, MPR, hepatitis, surface, antigen, HBsAg, epitope, Human , Immunodeficiency , Virus, vaccine, therapeutic, diagnostic, Berkower
Compounds Used to Improve Human Immune Responses in Diseases such as Allergies, Infections, and Cancer E-2000-011 Drugs Immunotherapy, Oncology, Viral Infectious Diseases, Bacterial Infectious Diseases,
Fungal & Parasitic Infectious Diseases
Cellular & Gene Therapy, Vaccines, Drug Design   2000 immune, oligonucleotide, CpG, therapeutic, immunomodulatory, humoral, cell-mediated, allergies, infectious, diseases, cancer, autoimmune, vaccine, adjuvant, DNA, anti-sense, Klinman, Verthelyi, Ishii
A Method with Increased Yield for Production of Polysaccharide-Protein Conjugate Vaccines Using Hydrazide Chemistry E-2003-025;
Biologics Viral Infectious Diseases, Bacterial Infectious Diseases Vaccines, Drug Design   2003 synthesis, manufacturing, polysaccharide, conjugate, vaccine, conjugation, PS, hydrazide, manufacturing, conjugate, Lee, Frasch
Method of Treating and Preventing Infections in Immunocompromised Subjects with Immunostimulatory CpG Oligonucleotides E-2002-018 Drugs, Biologics Pulmonary, Immunotherapy Cellular & Gene Therapy, Vaccines   2002 Lung, chronic, inflammatory, lung, emphysema, chronic, bronchitis, acute, respiratory, distress, syndrome, ARDS, inflammation, suppressive, oligonucleotide, pneumonia, Vaccine, adjuvant, production, immunotherapeutics, Klinman, Yamada
Methods for Preparing Complex Multivalent Immunogenic Conjugates E-2005-015 Biologics Viral Infectious Diseases, Bacterial Infectious Diseases Vaccines, Drug Design   2005 multivalent, immunogenic, conjugates, conjugate, vaccine, polysaccharide, hydrazide, conjugation, Lee
Monoclonal Antibodies Against Bordetella pertussis Filamentous Hemagglutinin (FHA) Protein E-2008-001 Biologics Bacterial Infectious Diseases Vaccines, Therapeutics, Diagnostics   2008  
Identification of a Cell-Surface Co-Receptor that Mediates the Uptake and Immunostimulatory Activity of "D" Type CpG Oligonucleotides E-2005-004 Drugs, Biologics Immunotherapy Cellular & Gene Therapy, Vaccines, Drug Delivery   2005 CpG, immune, proinflammatory, oligonucleotides, scavenger receptor, immune, Vaccine, adjuvant, production, immunotherapeutics, Klinman, Gursel
Hollow Waveguide Laser Delivery System for Digital Particle Image Velocity E-2006-001 Devices   Imaging   2006 laser, delivery, system, digital, particle, image, velocimetry, DPIV, illumination, Optics, Ilev, Robinson, Waynant
Confocal Fiber-Optic Laser Method for Intraocular Lens Power Measurement E-2005-007 Devices Ophthalmology Medical Devices   2005 fiber, optic, laser, confocal, Intraocular, lens, IOL, dioptic, power, measurement, single-mode, optical, Ilev
Ultrahigh-Resolution Fiber-Optic Confocal Microscope And Method E-2005-006 Devices   Medical Devices   2005 single, mode, fiber, optic, confocal, microscope, ultrahigh, resolution, illumination, Ilev, Waynant, Gannot, Gandjbakhche
Monoclonal Antibody 90.12 Specific to a Novel B Cell Surface Antigen Upregulated on Both Activated and Apoptotic Lymphocytes E-2004-019 Biologics Oncology Therapeutics   2004 Monoclonal, antibody, calcium, binding, proteins, Shapiro
Thermolytic Hydroxyl-Protecting Groups for Improved Oligonucleotide Synthesis E-2003-008 Biologics, Drugs Gene therapy Vaccines, Cellular & Gene Therapy, Drug Design, Diagnostics, Bioassays, Monitoring   2003 Synthetic, oligonucleotide, gene, therapy, diagnostic, DNA, sequencing, microarray, glass, synthesis, Beaucage, Chmielewski
Use of CpG Oligodeoxynucleotides to Encourage Angiogenesis E-2001-030 Biologics, Drugs Oncology Cellular & Gene Therapy   2001 angiogenesis, CpG, oligonucleotide, tumor, atherogenesis, arthritis, corneal, neovascularization, diabetic, retinopathy, wound, healing, malignancies, oligodeoxynucleotide, ODN, vaccine, adjuvant, anti-allergens, immune, central, nervous, system, cornea, VEGF, Vascular, Endothelial, Growth, Factor, Klinman
Microbial Identification Databases E-2000-025 Food, Biologics, Drugs, Animal & Veterinary Viral Infectious Diseases, Bacterial Infectious Diseases, Fungal & Parasitic Infectious Diseases, Food Safety, Environmental Science Monitoring, Post-Market Surveillance, Biodefense   2000 database, pyrolysis, mass, spectra, chemotaxonomy, microbial, MALDI, infrared, chromatogram, NMR, ion, mobility, microorganism, pathogen, Wilkes
Novel Method for Rapidly Generating Mature Dendritic Cells from Peripheral Blood Monocytes and Myeloid Precursors E-2001-019 Biologics, Drugs Immunotherapy Cellular & Gene Therapy, Therapeutics   2001 CpG, oligodeoxynucleotide, ODN, dendritic, DC, cytokines, chemokines, monocytes, dendritic, immune, cancer, infectious, disease, Klinman, Gursel, Verthelyi
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