FDA Technologies Available for Licensing and Collaboration
| Title | E # | Product Area | Research Area | Technologies & Applications | Development Stage | FY | Keywords |
|---|---|---|---|---|---|---|---|
| Stable cell line for validating next-generation sequencing (NGS) methods for detecting adventitious viruses contaminating biological products | E-2023-001 | Biologics testing and manufacturing including but not limited to viral vaccines, biotherapeutics, and cellular and gene therapy products | Cell Line | Therapeutics, Biologics | In vitro data available | 2023 | A549, adventitious, assay, biological material, biologics, biologics testing, biotherapeutics, cell line, cellular therapeutics, gene therapy, latent virus, next-generation sequencing, NGS, reference standard, simian foamy virus, validation, viral vaccines, virus |
| Identification and elimination of helper and cytotoxic T cell epitopes in AAV9 | E-2022-010 | Gene Therapy, Immunology Research, Assay Development | Gene Therapy, Diagnostic | Gene Therapy, Research Tool, Diagnostic | In vitro data available | 2022 | Helper T Cells, Cytotoxic T Cells, AAV9, Gene Therapy, Immunogenicity, AVV vectors, CD4, CD8, T Cells, Gene Delivery |
| Live attenuated Sars-CoV-2 vaccine candidate adaptable to emerging SARS-CoV-2 variants | E-2022-007 | Vaccine development, candidate SARS-CoV-2 vaccine | Vaccine Development | Research Tool, Vaccine and Diagnostic Development | Proof-of-concept, vaccine challenge studies in transgenic mice and in Syrian hamsters, and vaccine candidate | 2022 | COVID, COVID-19, Wang, live attenuated virus, Omicron, Delta, Wuhan-1, vaccine, vaccine development, SARS, SARS-CoV-2 |
| Computationally Engineered Anti-Sars-Cov-2 Monoclonal Antibodies with High Binding Affinities | E-2022-006 |
Research tools, diagnostic assays, vaccine development, therapeutic antibodies |
Vaccine Development, Diagnostics, Therapeutics | Vaccine Development, Diagnostics, Therapeutics | Monoclonal antibodies, expression plasmids, and in vitro characterization data | 2022 | SARS, SARS-CoV-2, SARS-CoV-1, monoclonal, antibodies, research tool, diagnostic, Sauna |
| Magnetic Resonance Spectra (MRS) Processing Software for Accurate Analysis | E-2022-005 | Software, medical diagnostic, research tool | Medical Devices, Diagnostics | Medical Devices, Diagnostics, MRI, MRS | Proof-of-concept | 2022 | MRI, MRS, medical imaging, medical device, software, Buzatu |
| Modified Factor Xa Polypeptides to Recover Clotting Activity in Subjects Treated with Direct Oral Anticoagulants (DOACs) | E-2022-003 | Biologics, Direct Acting Anticoagulants, DOACs, Thromboembolic Disease, Bleeding Disorders | Therapeutics, Biologics | Therapeutics, Biologics | Proof-of-concept, In vivo animal data | 2022 | biologic, bleeding disorders, blood clots, clotting, direct oral anticoagulants, DOACs, factor Xa, Sauna, Thromboembolic Disease |
| System and method for in vivo estimation of brain amyloid burden using X-rays | E-2022-001 |
Diagnostic imaging, neuroscience |
Medical Devices, Diagnostics | Medical Devices, Diagnostics, Imaging | prototype, proof of concept studies | 2022 | brain, amyloid plaque, X-rays, neurodegenerative disease, Alzheimer's, Parkinson's, PET, positron emission tomography, MRI, magnet resonance imaging |
| Lac operator-based mitigation of heterologous DNA instability in plasmids propagated in E. coli | E-2021-019 | Therapeutics, vaccine, biologics | Therapeutics, Bioprocessing | Therapeutics, Biologics, Protein, Production, Bioprocessing | In vitro data available | 2021 | Plasmid, DNA, Gene Expression, E. coli, biopharmaceutical, toxic gene, Lac Repressor, Influenza, Flu, Hemagglutinin, Neuraminidase, Reverse Genetics, viral protein, protein, vaccine, biologics, eukaryotic |
| Stable Non-infectious Cell Clones that Produce Functional SARS-CoV-2 RNA for Nonstructural Proteins and Accessory Proteins | E-2021-017 | Screening Tool, COVID-19, SARS-CoV-2, Antiviral Drugs, Screening | Viral Infectious Diseases | SARS-CoV-2 replication, screening compounds | Proof-of-concept for screening compounds, Research Tool | 2021 | Wang, Liu, SARS-CoV-2, COVID-19, cell clones, nonstructural proteins, accessory proteins |
| Chimeric immunotoxins targeting IL-13Ralpha2 positive human cancers | E-2021-010 | protein therapeutic, cancer, biologic, oncology | Oncology | protein therapeutic, cancer, biologic, oncology | In vivo animal data | 2021 | IL-13, IL-13R, cancer, head and neck cancer, prostate cancer, colorectal cancer, breast cancer, stomach cancer, cervical cancer, oncology, protein, chimeric, Pancreatic ductal adenocarcinoma, PDAC |
| Live Attenuated Rubella Vector to Express Vaccine Antigens | E-2012-003 | Research materials, tool, gene manipulation | Vaccine Development | Research Tool, HIV and Bivalent Rubella Vaccine Development | Pre-clinical, in vitro data available, in vivo data available (animal) | 2012 | Berkower, Virmik, HIV, rubella, SIV, SHIV, P150, vaccine, antigen |
| Adaptive Perfusion: A Novel In Vitro Release Test (IVRT) Method for Complex Drug Products | E-2020-025 | drug development, drug formulations, drug manufacturing, drug production, quality control, drug delivery | Drug development, drug manufacturing, quality control | Drug development, drug manufacturing, quality control, tangential flow filtration (TFF) | In vitro data, prototype | 2020 | Drug in vitro release testing, IVRT, drug dissolution testing, tangential flow filtration, formulation, drug development, quality control, emulsions, micelles, suspensions, liposomes, drug-protein complex |
| Chimeric antigen receptor (CAR)-T cells targeting IL-13Ralpha2 positive human solid cancers | E-2020-020 | CAR-T, Cellular therapeutics, cancer, biologic, oncology, solid tumors | CAR-T, Cellular therapeutics, cancer, biologic, oncology, solid tumors | CAR-T, Cellular therapeutics, cancer, biologic, oncology, solid tumors | In vivo animal data | 2020 | Chimeric antigen receptor T cell, CAR-T, cancer, solid tumors, cellular therapeutics, IL-13, IL-13R |
| Coronavirus sars cov-2, sars cov antigens, and rabbit polyclonal antibodies | E-2020-016 | Biologics | Viral Infectious Diseases | Vaccines | Research Materials | 2020 | Antibody, rabbit, coronavirus, SARS, antigen, sera, vaccine development, Khurana |
| A Novel Solid Support for Efficient Reduction of Process-Related Impurities in Synthetic Nucleic Acid Sequences | E-2020-015 | CPG support, nucleic acid-based drugs, solid-phase DNA/RNA synthesis | Synthetic nucleic acid synthesis | Purification of synthetic nucleic acid sequences | Proof of concept system | 2020 | DNA, RNA, Beaucage, Grajkowski |
| Mouse Monoclonal Antibodies Specific to Trypanosoma Cruzi Antigens | E-2020-014 | Research materials, monoclonal antibodies, Trypanosoma cruzi, Chagas | Chagas Disease | Research Tool, Diagnostic Test for Chagas Disease, Antigen testing to confirm disease status | Development assays to detect T. cruzi in mice and Chagas patients | 2020 | Chagas, T. cruzi, monoclonal antibodies, trypanosoma, Debrabant, Nagarkatti, Acosta |
| Hepg2-Fluc-Gluc and Hepg2-Fluc-Seap Cell Lines | E-2020-010 | Research Materials, Cell Line, In Vitro System | Cell line | Drug evaluations for drug-induced liver injury | Research Tool | 2020 | Cell Line, Liver Injury, Endoplasmic Reticulom, Gaussia Luciferase, Guo, Chen |
| Hybridomas for Monoclonal Antibodies Specific to Fragment B, Fragment C, and Light Chain of Tetanus Toxin | E-2020-002 | Research Materials, Antibody, Vaccine | Vaccine | In-vitro diagnostics, tetanus toxin and fragments research and development | Research Materials | 2020 | Tetanus, fragment C, antibodies, vaccine, tetani, Shapiro, Kenimer, Habig, Fitzsimmons, Hardegree |
| Cross-Protective Norovirus Epitope and Monoclonal Antibodies | E-2019-025, E-2019-026 | antigenic variation, caliciviruses, evolution, gastrointestinal, infection, norovirus, phylogenetic, virus, antibodies, neutralizing, epitope, method, peptide, monotypic, interfere, sequence, amino acid, binding, inhibiting, gene, genomics | Antiviral, virus, norovirus, diagnostic, assay development | diagnostic, assay development | In vitro data | 2019 | antigenic variation, caliciviruses, evolution, gastrointestinal, infection, norovirus, phylogenetic, virus, antibodies, neutralizing, epitope, method, peptide, monotypic, interfere, sequence, amino acid, binding, inhibiting, gene, genomics |
| Lentiviral vectors bearing il-13 that Target Human IL-13 Receptor alpha-2-Positive TUMOR Cells | E-2019-024 | Biologics | Oncology, basic research, Lentivirals | Bioassay, Diagnostics, Vaccine | Research Materials | 2019 | Lentiviral vector, IL-13, IL-13R |
| An Attenuated Live Mumps Virus Vaccine Candidate Expressing F and HN Protein Genes from Genotype G | E-2018-022 | Biologics | Viral Infectious Disease | Vaccines | In vivo animal data |
2018 | mumps, vaccine, immunity, disease, meningitis, virus, plasmid, strains, Rubin, gene, Jeryl Lynn, protein, genotype, recombinant, combination |
| Efficient Storage Algorithm for Time-Domain Spectrum Measurement | E-2018-016 | Algorithm, Software | wireless signaling, data compression | High-capacity storage of spectrum survey in a hospitals and healthcare systems | Validated on National Instruments (NI) vector signal transceiver platform in a healthcare environment | 2018 | Bluetooth, frequency, wireless, signal, storage, hospital, medical, device, spectrum, time-domain, platform, method, interference, data compression |
| Hybridomas Secreting Novel Monoclonal Antibodies Against the Nucleoprotein of Influenza Virus | E-2018-007 | Biologics | Viral Infectious Disease | Bioassay, Diagnostics, Vaccine | Research Material | 2018 | Influenza, Antibody, Vaccine, Diagnotic, Hongquan Wan |
| Enhanced Chemiluminescent Enzyme-Linked Immunosorbent Assay for Detection of Antibodies Against Babesia Microti | E-2017-031 | Diagnostic, Screening Tool, Babesia microti | Parasitic Infectious Diseases | Babesia testing in donor blood | Early development | 2017 | Kumar, Verma, Babesia, Babesiosis |
| Synergistic Antitumor Activity of Combination Immunotherapy IL-4 receptor targeted agents and Interferons -alpha and -gamma | E-2017-025 | Drugs, Oncology | Oncology | Biologic therapeutic | in vivo animal studies | 2017 | IL-4, interferon, puri, synergistic, ovarian, cancer, chimeric protein, pseudomonas exotoxin, IFNgamma, anti-interleukin, anti-interleukin-4, Husain, GrSynergistic Antitumor Activity of Combination Immunotherapy IL-4 receptor targeted agents and Interferons -alpha and -gamma |
| Reassortant Influenza Viruses Expressing Neuraminidase (NA) And A Mismatched Hemagglutinin (HA) Protein Useful for Determining Antibody Titers of Functional Na-Specific Antibodies | E-2017-022 | Biologics | Viral Infectious Diseases | Vaccines, Diagnostics, Therapeutics | In vitro data, Research Material | 2017 | Influenza, neuraminidase, HA, Hemagglutinin, virus |
| Listeria Monocytogene Strains Containing Antibiotic Resistance and Green-Flourescent Protein Markers | E-2017-020 | Biologics | Bacterial Infectious Diseases, Food Safety | Vaccines, quality control, proficiency testing materials, test kits, Diagnostics, assay validation, Monitoring | Research Material | 2017 | listeria, monocytogenes, pathogen, celery, contaminant, chicken, vaccine development, Datta, Sahu, Burall |
| Biological Classifier and Clustering Methods for High-Dimensional, Multivariate Measurement Data Sets Using the Grand Canonical Monte Carlo Ensemble | E-2017-017 | Bioinformatic, software, genomics | Software, bioinformatics, genomics | Software, bioinformatics, genomics | Software | 2017 | Software, bioinformatics, genomics, Monte Carlo Ensemble |
| Serum-Free Medium for the Isolation and Expansion of Canine Adipose-Derived Mesenchymal Stem/Stromal Cells | E-2017-010 | Research material, Supplement, Media, Serum | Stem cell, Stromal Cell | In-vitro diagnostics, tetanus toxin and fragments research and development | Research Material | 2017 | Mesenchymal Stem/Stromal Cells (MSCs), fetal bovine serum (FBS), Devireddy, Screven |
| Gonoccoccal Vaccine/Therapy from Neisseria meningitidis | E-2017-006 | Biologics | Viral infectious Diseases, bacterial infectious diseases | Vaccines, Drug Design | In vivo animal studies | 2017 | meningitis, meningitidis, Neisseria meningitidis, vaccine, N. meningitidis, N. gonorrhoeae |
| Factor H Binding Protein-Choleratoxin B Chimeric Vaccine Construct Against Neisseria Meningoccal Disease | E-2017-003 | vaccine development, adjuvant | Bacterial Infectious Diseases | Vaccine development for group N. meningitidis serogroup B strains | Early Proof of concept studies completed | 2017 | Neisseria Meningoccal, meningitidis, FHbp, choleratoxin, Bash, Price, Lee |
| Genetically Engineered Mouse Model Used as an Alternative Screening Method for Evaluating P-Glycoprotein Substrate Toxicity in Avermectin-Sensitive Dogs | E-2011-026 | Research materials, mouse model | Drug Safety | Drug screening technology to assess the toxicity of canine drugs to canines with the mutated form of the ABCB1 gene. | In vitro data available | 2011 | Yancy, ABCB1, avermectin, Ivermectin, canine, herding dogs |
| Flow Cytometry-Based Systems and Methods for Detecting Microbes | E-2011-022 | Foodborne illnesses, food safety, flow cytometer, microbial contamination | Foodborne illnesses, food safety, flow cytometer, microbial contamination | Foodborne illnesses, food safety, flow cytometer, microbial contamination | In vitro data, prototype | 2011 | foodborne illnesses, flow cytometry, microbial contamination, bacteria, virus, protozoa, prion, food safety |
| Pooled Human Complement Meningococcal Bactericidal Activity Assay | E-2014-008 | Method, immunoassay, vaccine development, assay development | Vaccine | Human bioassay development | Proof-of-concept | 2014 | Bash, Lynn, meningococcal, serogroup A |
| Anthrax Lethal Toxin Inhibits Proliferation of Human CD4+ t cells in Response to t cell Receptor Stimulation and Mitogen Stimulation Center |
E-2004-039 | anthrax bioassay, diagnostic, bioterrorism | Viral Infectious Diseases | Human bioassay development | Early proof-of-concept | 2004 | Bacillus anthracis, anthrax, Frucht, Fang, bioterrorism, bioassay |
| Improved Method of Allelic Exchange | E-2015-003 | Research materials, tool, gene, manipulation | Genetic alteration, allelic replacement | Simplified genetic manipulation without use of selectable markers | Research Materials | 2015 | Bordetella, Pertussis, parapertussis, bronchiseptica, Allelic, Stibitz |
| Software for 3D Spectral Fingerprint based consensus modeling using orthogonal pls and tanimoto similarity KNN techniques | E-2014-001 | Software | Molecular modeling, spectoral modeling | Drug design, drug development, software, research tool | 2014 | Research tool, software, bioinformatics, modeling, Slavov, Berger, Buzatu, Pearce | |
| Inactivation of Pathogens in Blood Products Using Visible Light | E-2014-013 | Antimicrobials, bacterial, infectious disease | Blood pathogen reduction | Blood Products, Pathogen Reduction, Infectious Disease, Antimicrobials | prototype, proof of concept | 2014 |
Antimicrobials, bacterial, infectious disease, blood products, pathogen reduction, Atreya, Maclean, Anderson, MacGregor |
| Anti-Influenza A Neuraminidase monoclonal antibodies | E-2015-001, E-2013-008, E-2019-012 | Animal & Veterinary | Research material, viral infectious diseases | Bioassays | Research material | 2015 |
Influenza, influenza virus, monoclonal antibody, neuraminidase, CD6, immunoassay, anti-neuraminidase, neuraminidase 1 (N1), neuraminidase 2 (N2), neuraminidase 9 (N9), research tools, diagnostic assays, vaccine development |
| Nonpathogenic Bacteria, Paenibacillus alvei, Useful As a Natural Biocontrol Agent for Elimination of Food-Borne Pathogenic Bacteria | E-2014-007 | Drugs | Bacterial Infectious Disease, Antimicrobial | Therapeutics, drug design | in vitro | 2014 | antimicrobial, peptides, bacterial, infectious disease, salmonela, paenibacillus alvei, bactericide |
| Hemoglobin-Polymer Phantoms for Biophotonic Device Performance Evaluation | E-2016-002 | Devices | Medical Devices | Imaging, Medical device |
Prototype | 2016 | hemoglobin polymer phantoms, biophotonic, device, imaging systems |
| Tissue-mimicking polymer test phantoms for optical-acoustic medical imaging. | E-2016-003 | Devices | Imaging, Medical Device | Prototype | 2016 | Photoacoustic, imaging, phantom, optical, acoustic, tunable, magnetic, tomography, diagnostic, sound, pfefer, tissue, mimic | |
| Anti-influenza Monoclonal Antibodies to Hemagglutinin (HA) That Are Suitable for Identification and Quantification of Seasonal Influenza Vaccines | E-2016-004 | Biologics | Viral Infectious Diseases | Bioassay, Diagnostics, Vaccine | In vitro data | 2016 | influenza, monoclonal, antibodies, glycoprotein, strain, epidemic, hemagglutinin, protein, pandemic, virus, vaccine, weir, H1N1, vaccination, diagnostic, assay |
| Solid-phase Purification of Synthetic DNA Sequences | Drugs | Chemicals, Pesticides, & Metals | Cellular and gene therapy, therapeutics, drug delivery | In vitro data | 2016 | solid-phase, purification, synthetic, DNA, sequence, high-throughput, method, design, purity, technique, nucleotide, manufacture, beaucage | |
| Therapeutic and Prophylactic Anti-Influenza Virus Neuraminidase 1 (N1) Antibody (Cd6) With a Novel Epitope That Spans Neuraminidase (Na) Dimers | E-2015-001 | Biologics | Viral Infectious Disease | Vaccines, Diagnostics, Bioassays |
in vitro and in vivo |
2015 | CD6, neutralizing antibody, neuraminidase, hemegglutinin, influenza virus, viral |
| Use of Nonpathogenic Bacteria, Paenibacillus Alvei, as a Natural Biocontrol Agent for Elimination of Food-Borne Pathogenic Bacteria | E-2011-003 | Food | Food Safety, Chemicals, Pesticides, & Metals | Therapeutics, drug design | Pre-development | 2011 | TS-15, food, borne, pathogens, Salmonella, Escherichia, Listeria, Shigella, Enterobacter, Staphylococcus, food supply, biocontrol, agent, pesticide, fruits, vegetable, food-borne, pathogen, antibiotic, resistant, Agriculture, Brown, Zhang |
| Nanoparticulate Complex of Nicotine and Cerium Oxide for the Treatment of Parkinson’s Disease | E-2014-002 | Drugs | Neuroscience & Pain | Nanotechnology | In vitro data | 2014 | tobacco, Parkinson's, nicotine, conjugate, nanoceria, anti-oxidant, oxidant, neuronal, Imam |
| Vaccine for Protection Against Shigella sonnei Disease | E-2001-016 | Biologics | Bacterial Infectious Diseases | Vaccines, Diagnostics | In vivo animal data | 2001 | Shigellosis, food, water, bacterium, Shigella, sonnei, antibiotics, resistant, vaccine, Shigellae, polysaccharide, immunoprotective, vaccine, mice, Shigella, Typhoid, Kopecko, Xu, Cisar |
| Typhoid-Plague Bivalent Vaccine | E-2011-007 | Biologics | Bacterial Infectious Diseases | Vaccines, Diagnostics, Therapeutics | 2011 | Yersinia, pestis, plague, flea, lungs, pneumonic, bioterrorist, vaccine, oral, construct, fusion, attenuated, typhoid, fever, bacterial, immune, anthrax, delivery, therapeutics, diagnostics, Vector, Kopecko, Osorio, Foote | |
| A Novel Anthrax Vaccine Candidate | E-2003-032 | Biologics | Bacterial Infectious Diseases | Vaccines, Diagnostics, Therapeutics | In vivo animal data | 2003 | vaccine, anthrax, injectable, anthracis, Escherichia, coli, alpha, hemolysin, typhoid, Salmonella, enterica, serovar, Typhi, Immunization, mice, serum, immunoglobulin, toxin, neutralizing, Vaccinated, intranasal, aerosolized, spores, Anthrax, Kopecko, Osorio, Giri, Blake, Bhattacharyya |
| Live Oral Shigella dysenteriae Vaccine | E-2004-022 | Biologics | Bacterial Infectious Diseases, Food Safety | Vaccines, Diagnostics, Therapeutics | in vivo | 2004 | Salmonella, typhi, construct, Shigella, dysenteriae, polysaccharide, Ty21a, constructs, immune, dysentery, serotypes, dysentery, shigellosis, Kopecko, Xu |
| Oral Shigellosis Vaccine | E-2012-016 | Biologics | Bacterial Infectious Diseases, Food Safety | Vaccines, Diagnostics, Therapeutics | 2012 | Salmonella, typhi, Shigella, sonnei, biosynthetic, constructs, immune, antigenic, bacterial, Bacillary, dysentery, enteric, fever, dysentery, vaccine, resistance, multivalent, Shigellosis, Dharmasena, Kopecko | |
| Synthetic Peptides with Antimicrobial Activity | E-2012-023 | Biologics | Bacterial Infectious Diseases | Therapeutics, Diagnostics | In vitro data | 2012 | synthetic, peptides, antimicrobial, E., coli, aeruginosa, S. aureus, S. epidermidis, B. cereus, K. pneumonia, platelets, plasma, cytotoxic, blood, toxicity, drug, development, resistant, bacterial, antimicrobial, Atreya, Rao, Ketha |
| Respiratory Syncytial Virus (RSV) Vaccine Candidates from RSV Glycoprotein (G) and Fusion (F) Protein | E-2013-016, E-2015-010, E-2018-001 |
Biologics | Viral Infectious Diseases | Vaccines | In vitro data | 2013, 2015, 2018 | cross, neutralizing, vaccine, human, respiratory, syncytial, viru, immunogenic, recombinant, vaccines, immunogenicity, Khurana, Golding |
| Software for Evaluating Drug Induced Hepatotoxicity | E-2012-008 | Software | Hepatology, drug interactions | Drug interactions, software, research tool | 2014 | hepatotoxicity, Guo, SAS, Research tool, software, liver | |
| Use of Cysteamine to Treat Metastatic Cancer | E-2013-010 | Drugs | Oncology, Neuroscience & Pain | Therapeutics | In vivo animal data | 2013 | Cysteamine, aminothiol, anti-oxidant, radiation, neurological, cancer, matrix, metalloproteinases, MMP, tumor, metastasis, metastasis, xenograft, umor, mice, therapeutic, Puri, Joshi |
| Therapeutic Hepatitis C Virus Antibodies | E-2012-002 | Biologics | Viral Infectious Diseases, Hepatology | Therapeutics | In vitro data | 2012 | Therapeutic, antibodies, Hepatitis, Virus, HCV, interfering, neutralizing, infection, monoclonal, liver, transplants, Feinstone, Duan, Major, Zhang, Kachko |
| Multivalent Meningiococcal Conjugates and Methods for Preparing Conjugates | E-2012-005 | Biologics | Bacterial Infectious Diseases | Vaccines | 2012 | meningococcal, polysaccharide, vaccines, tetravalent, PS, tetravalent, conjugate, meningococcal, Neisseria, meningitidis, immunogen, vaccine, autoimmune, immunogenic, conjugates, polysaccharide, Neisserial, Lee, Pinto | |
| Nanoparticle Probes and Mid-Infrared Chemical Imaging for DNA Microarray Detection | E-2010-015 | Biologics, Food | Environmental Science | Imaging, Nanotechnology, Diagnostics, Biomarkers | 2010 | microarray, visualization, infrared, chemical, imaging, IRCI, nanostructure, DNA, microarray, gene, expression, single, nucleotide, polymorphisms, SNPs, genome, signal-to-noise, SNR, hybridized, microarrayed, fluorescence, pathogenic, fluorescent, microarrays, protein, tissue, biochemical, chemical, toxicogenomics, microarray, Mossoba, Al-Khaldi, Schoen | |
| Filovirus Vaccines and Diagnostics Based on Glycoprotein-Fc Fusion Proteins | E-2010-018 | Biologics | Viral Infectious Diseases | Vaccines, Diagnostics | In vivo animal data | 2010 | Ebola, virus, Filoviridae, bioterrorism, hemorrhagic, fever, primates, Filovirus, subunit, vaccine, extracellular, glycoprotein, immunoglobulin, humoral, cellular, immunity, Vesicular, Stomatitis, Virus, response, Vaccine, virus-like particles, Kaplan, Konduru, Bavari, Bradfute |
| Purified Saxitoxin for Food Safety Applications | E-2009-010 | Food | Natural Toxins, Food Safety | Biomarkers, Bioassays | 2009 | Saxitoxin, toxins, seafood, food, borne, illness, Monitoring, contamination, Detection, poisons, Hall | |
| Peptides for HIV-1 Infection Detection Assay for Seroconverted HIV-1 Vaccine Recipients | E-2004-030 | Biologics | Viral Infectious Diseases | Bioassays | 2004 | ||
| Highly Adaptable Internal Control Nucleic Acid Molecule for Real-Time Polymerase Chain Reaction | E-2003-016 | Biologics, Food, Devices | Diagnostics, Bioassays | Diagnostics, Bioassays | 2003 | PCR, internal, control, system, real, time, PCR, kinetic, Q-PCR, conventional, assay, Vickery, DePaola, Blackstone | |
| Direct Impact Spark Ionization (DISI) Mass Spectrometry (MS) for Identification of Microbes | E-2011-021 | Devices | Food Safety, Environmental Science | Monitoring, Biodefense | 2011 | mass, spectrometry, device, direct, impact, spark, ionization, microbial, analytes, identification, pectral, pattern, recognition, microbiological, pathogen, determination, drugs, food, cosmetic, ingredients, monitoring, airborne, Biological, Warfare, Agents, Pathogen, bacterial, Wilkes, Alusta, Dorey, Parker, Buzatu | |
| Bacterially Expressed Influenza Virus Recombinant HA Proteins for Vaccine and Diagnostic Applications | E-2010-004 | Biologics | Viral Infectious Diseases | Vaccines, Diagnostics | 2010 | H1N1, influenza, virus, Avian, pandemic, chicken, egg, HA, H1N1, H5N1, neutralizing, antibody, in vivo, animal , models, vaccine, diagnostic, Golding, Khurana | |
| Novel Methods for the Reversible Incorporation of Functional Groups into RNA and DNA: Synthesis and Uses for 2'-O-aminooxymethyl Nucleoside Derivatives | E-2010-019 | Drugs, Biologics | Diagnostics, Cellular & Gene Therapy, Drug Delivery, Small Molecule Therapeutics, Drug Design | 2010 | DNA, RNA, therapeutic, drugs, silencing, expression, genes, interference, synthetic, synthesis, oligonucleotides, diagnostic, therapeutic, Beaucage, Cieslak | ||
| Meningococcal and Pneumococcal Conjugate Vaccine and Method of Using Same | E-2010-002 | Biologics | Bacterial Infectious Diseases | Vaccines | 2010 | Pneumococcal, Streptococcus, pneumoniae, pneumonia, meningitis, febrile, bacteremia, otitis, media, sinusitis, bronchitis, Vaccination, microbial resistance, bacterial, meningococcus, Neisseria, meningitidis, respiratory, meningeal, septic, pneumonia, meningitis, vaccine, pathogen, conjugate, vaccines, recombinant, Lee | |
| System for Magnetic Resonance Spectroscopy of Brain Tissue for Pattern-based Diagnostics | E-2009-011 | Devices | Neuroscience & Pain | Medical Devices, Imaging | 2009 | Magnetic, resonance, spectroscopy, MRS, Brain, Tissue, Pattern, Based, Diagnostic, Preprocessing, Module, Spectrum, Normalize, Scan, Raw, MRI, Brain, Imaging, Neurology, Wilkes, Buzatu, Alusta, Pearce, Kretzer, Im, Beger | |
| Insertion of Foreign Genes in Rubella Virus and their Stable Expression in a Live, Attenuated Viral Vaccine | E-2008-011 | Biologics | Viral Infectious Diseases | Vaccines | 2008 | Rubella, virus, RUB, Rubivirus, Togaviridae, genes, vector, live, vaccine, HIV, vector, expression, Berkower, Spadaccini | |
| A Hand Held Portable Device Based on LEDS for Use in The Detection of Counterfeit Pharmaceutical Drugs and Packaging | E-2008-017 | Devices, Drugs | Post-Market Surveillance, Monitoring | Prototype | 2008 | hand, held, portable, device, detection, counterfeited, pharmaceutical, prototype, light, emitting, diode, LED, Testing, authenticity, Ranieri | |
| Novel Oligonucleotides for Treatment of Human Cancer | E-2008-007 | Drugs, Biologics | Oncology | Therapeutics, Cellular & Gene Therapy | 2008 | Human, endogenous, retroviruses, HERV, antisense, sense, oligonucleotides, RNA, ERV-9, LTR, cancer, breast, liver, prostate, myeloid, fibrosarcoma, therapeutic, tumor, siRNA, gene, expression, Therapeutic, Xu, Rosenberg, Elkahloun, Candotti | |
| Controlled Formation of CpG Oligonucleotide Multimers | E-2004-024 | Drugs, Biologics | Adjuvants; Vaccines; Oligonucleotide Therapeutics | Drug design; Cellular and gene therapies; Molecule delivery | in vitro data; in vivo data; preclinical primate studies | 2004 | CpG, oligonucleotides, oligonucleotide, prodrug, Therapeutic, immune, immunostimulatory, Verthelyi, Beaucage, Grajkowski |
| Use of Sterically Stabilized Cationic Liposomes to Efficiently Deliver CpG Oligonucleotides in vivo | E-2001-020 | Drugs | Immunotherapy | Drug Delivery, Drug Design, Cellular & Gene Therapy | In vitro data, In vivo animal data | 2001 | Immunostimulatory, CpG, oligonucleotide, ODN, immune, adjuvant, anti-allergens, Sterically, Stabilized, Cationic, Liposomes, SSCL, in vivo, in vitro, mice, L. monocytogenes, listeria, Klinman, Gursel |
| Identification of DNA Sequence Motifs that Suppress the Immune Response to CpG DNA | E-2001-021 | Drugs | Immunotherapy | Cellular & Gene Therapy | 2001 | CpG, oligonucleotide, immunostimulatory, oligodeoxynucleotides, ODN, septic, shock, adult, respiratory, distress, syndrome, ARDS, autoimmune, disease, suppressive, vaccine, therapeutic, Klinman, Gursel | |
| Monoclonal Antibodies to Fusion-Active Conformations of HIV-gp41 | E-2007-011 | Biologics | Viral Infectious Diseases | Bioassays, Therapeutics | 2007 | monoclonal, HIV, gp41, tool, screening, antiretroviral, Research, Weiss, Vassell | |
| Diagnostic Targets and Potential Vaccine Against H5N1 Avian Influenza | E-2007-026 | Biologics | Viral Infectious Diseases | Therapeutics, Vaccines | in vivo studies | 2007 | peptide, polypeptide, influenza, virus , immunogenic, neutralizing, antibodies, avian, H1N1, H3N2, H5N1, H7N7, immunogenic, adjuvant, vaccine, Diagnostic, Golding, Khurana |
| Oligodeoxynucleotide and Its Use To Induce an Immune Response | E-1999-009 | Biologics | Oncology, Immunotherapy | Cellular & Gene Therapy, Vaccines | 1999 | oligodeoxynucleotides, ODN, CpG, immunostimulatory, immune, production, T cell, therapeutic, cancer, vaccine, adjuvant, autoimmune, disorders, immune, deficiencies, anti-infective, antisense, therapy, Klinman, Verthelyi, Ishii, Gursel | |
| Neutralization of Hepatitis C Virus (HCV) | E-2007-028 | Viral Infectious Diseases | Therapeutics | 2007 | |||
| Improved Immunotherapeutic Compositions for Treatment, Diagnosis and Prevention of HIV | E-2008-027 | Biologics | Viral Infectious Diseases | Therapeutics, Vaccines, Diagnostics | 2008 | HIV, vaccine, neutralizing, antibodies, glycoprotein, immune, immunization, gp120, immunogen, polypeptide, virus-like, particles, TLR, therapeutics, diagnostics, Berkower | |
| Mouse Monoclonal Antibody Targeting Tetanus Toxin Heavy Chain Fragment C | E-2009-003 | Biologics | Bacterial Infectious Diseases, Natural Toxins | Therapeutics | 2009 | murine, monoclonal, antibody, tetanus, toxin, neurotoxin, neuron, botulinum, antitoxins, Shapiro, Fitzsimmons | |
| Membrane Proximal Region of HIV gp41 Anchored to the Lipid Layer of a Virus-Like Particle Vaccine | E-2008-026 | Biologics | Viral Infectious Diseases | Therapeutics, Vaccines, Diagnostics | 2008 | HIV, envelope, glycoprotein, gp120, gp41, immunogenic, antibodies, immune, membrane, proximal, region, MPR, hepatitis, surface, antigen, HBsAg, epitope, Human , Immunodeficiency , Virus, vaccine, therapeutic, diagnostic, Berkower | |
| Compounds Used to Improve Human Immune Responses in Diseases such as Allergies, Infections, and Cancer | E-2000-011 | Drugs | Immunotherapy, Oncology, Viral Infectious Diseases, Bacterial Infectious Diseases, Fungal & Parasitic Infectious Diseases |
Cellular & Gene Therapy, Vaccines, Drug Design | 2000 | immune, oligonucleotide, CpG, therapeutic, immunomodulatory, humoral, cell-mediated, allergies, infectious, diseases, cancer, autoimmune, vaccine, adjuvant, DNA, anti-sense, Klinman, Verthelyi, Ishii | |
| A Method with Increased Yield for Production of Polysaccharide-Protein Conjugate Vaccines Using Hydrazide Chemistry | E-2003-025; E-2003-026 |
Biologics | Viral Infectious Diseases, Bacterial Infectious Diseases | Vaccines, Drug Design | 2003 | synthesis, manufacturing, polysaccharide, conjugate, vaccine, conjugation, PS, hydrazide, manufacturing, conjugate, Lee, Frasch | |
| Method of Treating and Preventing Infections in Immunocompromised Subjects with Immunostimulatory CpG Oligonucleotides | E-2002-018 | Drugs, Biologics | Pulmonary, Immunotherapy | Cellular & Gene Therapy, Vaccines | 2002 | Lung, chronic, inflammatory, lung, emphysema, chronic, bronchitis, acute, respiratory, distress, syndrome, ARDS, inflammation, suppressive, oligonucleotide, pneumonia, Vaccine, adjuvant, production, immunotherapeutics, Klinman, Yamada | |
| Methods for Preparing Complex Multivalent Immunogenic Conjugates | E-2005-015 | Biologics | Viral Infectious Diseases, Bacterial Infectious Diseases | Vaccines, Drug Design | 2005 | multivalent, immunogenic, conjugates, conjugate, vaccine, polysaccharide, hydrazide, conjugation, Lee | |
| Monoclonal Antibodies Against Bordetella pertussis Filamentous Hemagglutinin (FHA) Protein | E-2008-001 | Biologics | Bacterial Infectious Diseases | Vaccines, Therapeutics, Diagnostics | 2008 | ||
| Identification of a Cell-Surface Co-Receptor that Mediates the Uptake and Immunostimulatory Activity of "D" Type CpG Oligonucleotides | E-2005-004 | Drugs, Biologics | Immunotherapy | Cellular & Gene Therapy, Vaccines, Drug Delivery | 2005 | CpG, immune, proinflammatory, oligonucleotides, scavenger receptor, immune, Vaccine, adjuvant, production, immunotherapeutics, Klinman, Gursel | |
| Hollow Waveguide Laser Delivery System for Digital Particle Image Velocity | E-2006-001 | Devices | Imaging | 2006 | laser, delivery, system, digital, particle, image, velocimetry, DPIV, illumination, Optics, Ilev, Robinson, Waynant | ||
| Confocal Fiber-Optic Laser Method for Intraocular Lens Power Measurement | E-2005-007 | Devices | Ophthalmology | Medical Devices | 2005 | fiber, optic, laser, confocal, Intraocular, lens, IOL, dioptic, power, measurement, single-mode, optical, Ilev | |
| Ultrahigh-Resolution Fiber-Optic Confocal Microscope And Method | E-2005-006 | Devices | Medical Devices | 2005 | single, mode, fiber, optic, confocal, microscope, ultrahigh, resolution, illumination, Ilev, Waynant, Gannot, Gandjbakhche | ||
| Monoclonal Antibody 90.12 Specific to a Novel B Cell Surface Antigen Upregulated on Both Activated and Apoptotic Lymphocytes | E-2004-019 | Biologics | Oncology | Therapeutics | 2004 | Monoclonal, antibody, calcium, binding, proteins, Shapiro | |
| Thermolytic Hydroxyl-Protecting Groups for Improved Oligonucleotide Synthesis | E-2003-008 | Biologics, Drugs | Gene therapy | Vaccines, Cellular & Gene Therapy, Drug Design, Diagnostics, Bioassays, Monitoring | 2003 | Synthetic, oligonucleotide, gene, therapy, diagnostic, DNA, sequencing, microarray, glass, synthesis, Beaucage, Chmielewski | |
| Use of CpG Oligodeoxynucleotides to Encourage Angiogenesis | E-2001-030 | Biologics, Drugs | Oncology | Cellular & Gene Therapy | 2001 | angiogenesis, CpG, oligonucleotide, tumor, atherogenesis, arthritis, corneal, neovascularization, diabetic, retinopathy, wound, healing, malignancies, oligodeoxynucleotide, ODN, vaccine, adjuvant, anti-allergens, immune, central, nervous, system, cornea, VEGF, Vascular, Endothelial, Growth, Factor, Klinman | |
| Microbial Identification Databases | E-2000-025 | Food, Biologics, Drugs, Animal & Veterinary | Viral Infectious Diseases, Bacterial Infectious Diseases, Fungal & Parasitic Infectious Diseases, Food Safety, Environmental Science | Monitoring, Post-Market Surveillance, Biodefense | 2000 | database, pyrolysis, mass, spectra, chemotaxonomy, microbial, MALDI, infrared, chromatogram, NMR, ion, mobility, microorganism, pathogen, Wilkes | |
| Novel Method for Rapidly Generating Mature Dendritic Cells from Peripheral Blood Monocytes and Myeloid Precursors | E-2001-019 | Biologics, Drugs | Immunotherapy | Cellular & Gene Therapy, Therapeutics | 2001 | CpG, oligodeoxynucleotide, ODN, dendritic, DC, cytokines, chemokines, monocytes, dendritic, immune, cancer, infectious, disease, Klinman, Gursel, Verthelyi |