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Nanoparticle Probes and Mid-Infrared Chemical Imaging for DNA Microarray Detection

Nanoparticle Probes and Mid-Infrared Chemical Imaging for DNA Microarray Detection

The technology offered for licensing is a faster, more flexible, cost-effective microarray visualization. The invention describes and claims the mid-infrared chemical imaging (IRCI) to detect nanostructure-based DNA microarrays, which can be utilized in the life science research arena to examine gene expression and single nucleotide polymorphisms (SNPs), as well as to characterize entire genomes. The IRCI improves the signal-to-noise ratio (SNR) obtained for hybridized microarrayed spots compared to the commonly used fluorescence detection method. The improved method of this invention results in the sensitivity and precision for detecting pathogenic bacterial genes and can be utilized to detect low-expressing genes which cannot be identified by fluorescent-based DNA microarrays. Furthermore, the automated IRCI systems can also be fabricated for the dedicated detection of other (protein, tissue, biochemical, or chemical) microarrays.

Potential Commercial Applications:

  • DNA microarrays can be applied to the areas of environmental sciences, agriculture research, bio-defense, diagnostics, forensics, pharmacogenomics and toxicogenomics.

Competitive Advantages:

  • The invention provides a cost-effective, faster, more flexible, and less labor intensive microarray technology.


Inventors:
Magdi Mossoba
Sufian Al-Khaldi
Brianna Schoen
Betsy Yakes

Intellectual Property:
PCT Application No. PCT/US2011/056248
US Application No. 13/879,157

Licensing Contact:
Bill Ronnenberg, JD-MIP, MS
FDA Technology Transfer Program
10903 New Hampshire Ave.
Building WO1, Rm 4214
Silver Spring, MD 20993
Email: FDAInventionlicensing@fda.hhs.gov
Phone: 240-402-4561

OTT Reference No: E-127-2010/0
Updated: August 5, 2015