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Mouse Monoclonal Antibody Targeting Tetanus Toxin Heavy Chain Fragment C

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Technology Summary

The FDA is pleased to announce as available to license a murine monoclonal antibody that specifically binds to Fragment C of tetanus toxin. Tetanus toxin is one of the most potent neurotoxins known. It is a complex molecule, composed of a linked heavy chain and light chain, each having different domains serving different functions. One domain of the heavy chain, known as "Fragment C," is known to bind the toxin to neurons. Fragment C is the focus of much research, including: analysis of the subtle differences between neuronal uptake of tetanus toxin and the related botulinum toxin, the design of compounds that block the uptake of tetanus toxin, and design of drugs that target the same cellular mechanism to enhance uptake.

Potential Commercial Applications Competitive Advantages
  • Cell-based imaging agents
  • New drug development, including antitoxins
  • Toxin specific antibodies

Inventors: Marjorie Shapiro, Sean Fitzsimmons

Fitzsimmons, S. P. et. al.. Inhibition of tetanus toxin fragment C binding to ganglioside G(T1b) by monoclonal antibodies recognizing different fragment C epitopes. Vaccine 2000 Aug 15;19(1):114-121. PMID: 10924793

Intellectual Property: 
Research Materials -- patent protection is not being pursued for this technology

Product Area:

FDA Reference No: E-2009-003

Licensing Contact:
Ken Millburne, J.D.
FDA Technology Transfer Program
Email: FDAInventionlicensing@fda.hhs.gov 
Phone: 301-346-3964

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