Novel Oligonucleotides for Treatment of Human Cancer
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Human endogenous retroviruses (HERVs) are remnants of retroviruses that invaded and integrated into the human genome 6-15 million years ago. An important class of HERV retroviruses is ERV-9, which accounts for ~5% of the total human genome. The human genome contains approximately 50 copies of ERV-9 along with 3000-4000 copies of solitary elements of ERV-9 regulatory regions, called long terminal repeats (LTRs). The solitary LTRs contain promoter and enhancer elements that drive expression of genes located proximally to the LTR. Insertion of an ERV-9 LTR proximal to an oncogene could initiate carcinogenesis.
FDA researchers developed antisense and sense oligonucleotides (oligos) that target the RNAs of ERV-9 LTR as a treatment for various cancers, including human breast, liver, prostate, and myeloid cancers and fibrosarcomas. The inventors have shown the ERV-9 LTR sense and antisense oligos can inhibit cancer cell proliferation in vitro more efficiently than the antisense oligos of Bcl-2 (G3139) and telomerase (GRN163), both currently in cancer clinical trials. The oligos have minimal effects on the proliferation of primary normal human cells in vitro. The oligos also have potential as new therapeutic agents to suppress tumor cell growth, either when used alone or in combination with other antisense oligos or chemotherapeutic agents such as VePesid.
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Inventors: Lai Xu, Amy Rosenberg, Abdel Elkahloun, Fabio Candotti
Intellectual Property: United States Patent No 8,680,065 issued 03.25.2014
Product Area: Therapeutics, adjuvant therapy, cancer treatment, fibrosarcoma.
FDA Reference No: E-2008-007
Ken Millburne, J.D.
FDA Technology Transfer Program