Conjugate vaccine is composed of a bacterial polysaccharide covalently linked to a carrier protein. The covalent linkage renders the otherwise T-cell independent polysaccharide antigen to become T-cell dependent thus inducing long term immunity.
In this invention, FDA inventors prepared conjugate vaccine of group C meningococcal capsular polysaccharide (MCPS) to pneumococcal cell surface adhesin A (PssA). The conjugate is immunogenic in mice, inducing antibodies specific to MCPS and PssA. Per in vitro assay, the induced anti-MCPS antibody is bactericidal against homologous bacteria. Further, the carrier protein in this conjugate induces much more antibody than the lone protein. This invention can potentially be used to produce conjugate vaccines protective against Meningococcus (groups A, C, W135 and Y) and Pneumococcus of all serotypes.
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Inventors: Che-Hung Robert Lee, Stanley Tai
Product Area: Conjugate vaccine, Meningococcal / pneumococcal vaccine, MCPS, PssA
FDA Reference No: E-2010-002
Ken Millburne, J.D.
FDA Technology Transfer Program