FDA researchers have developed a novel high-throughput method for purifying full-length phosphorothioate and native DNA sequences. This method comprises a modified silica gel that enables capture of DNA sequences functionalized with a novel linker specifically designed for exclusive capture of full-length sequences. This technology can generate DNA sequences of high purity without the need of expensive equipment and associated accessories. This discovery may improve the availability of pure DNA sequences for clinical and/or synthetic biology applications.
|Potential Commercial Applications||Competitive Advantages|
Development Stage: in vitro data
Inventors: Serge Beaucage, Andrzej Grajkowski
“Solid-Phase Purification of Synthetic DNA Sequences.” J. Org. Chem. 2016 Aug 5;81(15):6165-75 PMID: 27382974
PCT/US2017/039720, filed 6/28/17
United States patent application: 16/312,445, filed 12/21/2018
Product Area: Drugs
FDA Reference No:E-2016-005
Charlene Maddox, Ph.D.
FDA Technology Transfer Program