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  1. Laboratory Methods (Food)

Other Analytical Methods of Interest to the Foods Program

The following are analytical laboratory methods of interest to the Foods Program, but are not currently part of the FDA Foods Program Compendium of Analytical Laboratory Methods. 

Other FDA Chemical Methods of Interest

The following methods lack sufficient validation status to be included in the Chemical Analysis Manual (CAM) or any another established Foods Program methods collection (e.g., Elemental Analysis Manual).  These methods may be of interest because they have been used in one-time surveys or have been selected for future validation. 

Analyte

Matrix

Method Title

Acrylamide

Multiple foods

Detection and Quantitation of Acrylamide in Foods

Benzene

Soft drinks and beverages

Determination of Benzene in Soft Drinks and Other Beverages

Ephedrine alkaloids

Botanical and dietary supplements

FDA's Analytical Methods for Testing of Products Believed to Contain Ephedrine Alkaloids

Furan

Multiple foods

Determination of Furan in Foods

Perchlorate

Fruits, vegetables, milk, low moisture foods, infant foods, and water

Rapid Determination of Perchlorate Anion in Foods by Ion Chromatography–Tandem Mass Spectrometry

Melamine and cyanuric acid

Animal tissue and milk-based infant formula

Method for Determination of Melamine and Cyanuric Acid Residues In Foods using LC-MS/MS

Other FDA Microbiological Methods of Interest

The following microbiological methods are in use in FDA laboratories or are cited by FDA compliance programs or FDA guidance documents, but lack multi-laboratory validation status and are not included in the FDA Foods Program Compendium of Analytical Laboratory Methods: Microbiological Methods.  In some cases the methods have been validated at the single laboratory level under the Foods Program Guidelines for the Validation of Analytical Methods for the Detection of Microbial Pathogens and have been used in small-scale assignments at a limited number of FDA laboratories.  If these single laboratory validated methods are slated for continued use, they will undergo multi-laboratory evaluation using FDA’s guidelines, and if validated, will be included in the BAM.  FDA considers the methods listed below are judged to be acceptable for their intended uses.   

Analytes

Matrix

Method Title

All microorganisms

Tattoo inks

Microbiological Methods for Testing the Sterility of Tattoo Inks

E. coli

Agricultural water

Equivalent Testing Methodologies for Agricultural Water, September 2017

 

E. coli O157:H7,

Salmonella

Sprout irrigation water, sprout samples

Equivalent Testing Methodologies for E. coli O157:H7 and Salmonella in Spent Sprout Irrigation Water or Sprouts Samples, October 2018

E. coli O157:H7,

Salmonella

Sprout irrigation water, sprout samples

Testing Methodologies for E. coli O157:H7 and Salmonella species in Spent Sprout Irrigation Water (or Sprouts),  October 2015

Listeria spp., Listeria monocytogenes

Environmental samples

Testing Methodology for Listeria species or Listeria monocytogenes in Environmental Samples, October 2015

Listeria spp., Listeria monocytogenes

Environmental samples

Equivalent Testing Methodologies for Listeria species and Listeria monocytogenes in Environmental Samples

Nontuberculous mycobacterium

Tattoo inks

Isolation and Identification of Nontuberculous Mycobacteria in Tattoo Inks

Salmonella Enteritidis

Environmental samples

Environmental Sampling and Detection of Salmonella in Poultry Houses

Salmonella Enteritidis

Environmental samples

Testing Methodology for Salmonella Enteritidis (SE)

Salmonella Enteritidis

Environmental samples Detection of Salmonella in Environmental Samples from Poultry Houses