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Oncology Center of Excellence Guidance Documents

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FDA Guidiancee

Listed below are recently added guidance documents regarding oncology and hematologic malignancies.

Title Type Date Posted
Use of Circulating Tumor Deoxyribonucleic Acid for Early-Stage Solid Tumor Drug Development Final November 2024
Assessment of Ovarian Toxicity in Premenopausal Adults During Drug Development for Oncologic Products Draft November 2024
Core Patient-Reported Outcomes in Cancer Clinical Trials Final October 2024
Considerations for Generating Clinical Evidence from Oncology Multiregional Clinical Development Programs Draft September 2024
Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases Final August 2024
Bacillus Calmette-Guérin-Unresponsive Nonmuscle Invasive Bladder Cancer: Developing Drugs and Biologics for Treatment Draft August 2024
Diversity Action Plans to Improve Enrollment of Participants from Underrepresented Populations in Clinical Studies Draft June 2024
Cancer Clinical Trial Eligibility Criteria: Washout Periods and Concomitant Medications Draft April 2024
Cancer Clinical Trial Eligibility Criteria: Performance Status Draft April 2024
Cancer Clinical Trial Eligibility Criteria: Laboratory Values Draft April 2024
Real-Time Oncology Review (RTOR) Final November 2023
Graft-versus-Host Diseases: Developing Drugs, Biological Products, and Certain Devices for Prevention or Treatment Draft September 2023
Postmarketing Approaches to Obtain Data on Populations Underrepresented in Clinical Trials for Drugs and Biological Products Draft August 2023
QTc Information in Human Prescription Drug and Biological Product Labeling Draft August 2023
Oncology Drug Products Used with Certain In Vitro Diagnostic Tests: Pilot Program Final June 2023
Clinical Trial Considerations to Support Accelerated Approval of Oncology Therapeutics Draft March 2023
Pharmacokinetic-Based Criteria for Supporting Alternative Dosing Regimens of Programmed Cell Death Receptor-1 (PD-1) or Programmed Cell Death-Ligand 1 (PD-L1) Blocking Antibodies for Treatment of Patients with Cancer Final December 2022
Cross Labeling Oncology Drugs in Combination Regimens Final November 2022
Acute Myeloid Leukemia: Developing Drugs and Biological Products for Treatment Final October 2022
Tissue Agnostic Drug Development in Oncology Draft October 2022
Characterizing, Collecting, and Reporting Immune-Mediated Adverse Reactions in Cancer Immunotherapeutic Clinical Trials Draft October 2022
Cancer Clinical Trial Eligibility Criteria: Available Therapy in Non-Curative Settings Final July 2022
Renal Cell Carcinoma: Developing Drugs and Biologics for Adjuvant Treatment Final June 2022
Bladder Cancer: Developing Drugs and Biologics for Adjuvant Treatment Final June 2022
Advanced Prostate Cancer: Developing Gonadotropin-Releasing Hormone Analogues Final May 2022
Inclusion of Older Adults in Cancer Clinical Trials Final March 2022
Expansion Cohorts: Use in First-In-Human Clinical Trials to Expedite Development of Oncology Drugs and Biologics Final March 2022
Master Protocols: Efficient Clinical Trial Design Strategies to Expedite Development of Oncology Final March 2022
Nonmetastatic, Castration-Resistant Prostate Cancer: Considerations for Metastasis-Free Survival Endpoint in Clinical Trials Final August 2021
Evaluating Cancer Drugs in Patients with Central Nervous System Metastases Final July 2021
Premenopausal Women with Breast Cancer: Developing Drugs for Treatment Final June 2021
Chemotherapy-Induced Nausea and Vomiting: Developing Drugs for Prevention Draft May 2021
COVID-19: Master Protocols Evaluating Drugs and Biological Products for Treatment or Prevention Final May 2021
FDARA Implementation Guidance for Pediatric Studies of Molecularly Targeted Oncology Drugs: Amendments to Sec. 505B of the FD&C Act Final May 2021
Geriatric Information in Human Prescription Drug and Biological Product Labeling Draft September 2020
Male Breast Cancer: Developing Drugs for Treatment Final August 2020
Pediatric Study Plans: Content of and Process for Submitting Initial Pediatric Study Plans and Amended Initial Pediatric Study Plans Final July 2020
Pathological Complete Response in Neoadjuvant Treatment of High-Risk Early-Stage Breast Cancer: Use as an Endpoint to Support Accelerated Approval Final July 2020
Setting Endotoxin Limits During Development of Investigational Oncology Drugs and Biological Products Draft July 2020
Cancer Clinical Trial Eligibility Criteria: Patients with HIV, Hepatitis B Virus, or Hepatitis C Virus Infections Final July 2020
Cancer Clinical Trial Eligibility Criteria: Patients with Organ Dysfunction or Prior or Concurrent Malignancies Final July 2020
Cancer Clinical Trial Eligibility Criteria: Brain Metastases Final July 2020
Cancer Clinical Trial Eligibility Criteria: Minimum Age Considerations for Inclusion of Pediatric Patients Final July 2020
Developing and Labeling In vitro Companion Diagnostic Devices for a Specific Group or Class of Oncology Therapeutic Products Final April 2020
Hematologic Malignancies: Regulatory Considerations for Use of Minimal Residual Disease in Development of Drug and Biological Products for Treatment Final January 2020
Investigational In Vitro Diagnostics in Oncology Trials: Streamlined Submission Process for Study Risk Determination Final October 2019
Placebos and Blinding in Randomized Controlled Cancer Clinical Trials for Drug and Biological Products Final August 2019
Oncology Therapeutic Radiopharmaceuticals: Nonclinical Studies and Labeling Recommendations Final August 2019
Oncology Pharmaceuticals: Reproductive Toxicity Testing and Labeling Recommendations Final May 2019
Considerations for the Inclusion of Adolescent Patients in Adult Oncology Clinical Trials Final March 2019
Clinical Trial Endpoints for the Approval of Cancer Drugs and Biologics Final December 2018
S9 Nonclinical Evaluation for Anticancer Pharmaceuticals—Questions and Answers Final June 2018
Commenting on Guidance Documents

Some FDA guidance documents on this list are indicated as open for comment. Although you can comment on any guidance at any time (see 21 CFR 10.115(g)(5)), to ensure that the Agency considers your comment on a draft guidance that is open for comments before it begins work on the final version of the guidance, submit either electronic or written comments by the closing date. Comments are submitted electronically through regulations.gov. For more information, see:

About FDA Guidances

Guidance documents represent the Agency's current thinking on a particular subject. They do not create or confer any rights for or on any person and do not operate to bind FDA or the public. An alternative approach may be used if such approach satisfies the requirements of the applicable statute, regulations, or both. For information on a specific guidance document, please contact the originating office. Another method of obtaining guidance documents is through the Division of Drug Information.

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