Outcomes
To identify adverse events (AEs) or health outcomes of interest (HOIs) in health care databases including administrative claims, electronic health records [EHR], and linked claims-EHRs, rule-based algorithms are developed utilizing reimbursement or health care management coding systems as well as clinical and auxiliary data elements. These algorithms may also apply health care settings, demographic and other specific population characteristics, and time criteria. Based on prevalence and clinical characteristics, some of these algorithms may be feasible to be validated by reviewing patients’ medical records. The health outcomes may be employed as outcomes, identification of study populations, or covariates in observational studies depending on the study objectives. The portability of these algorithms across populations and databases depends on the similarities of the populations and databases characteristics.