Spectrum of Diseases/Conditions

Contents:

Anesthesia
Anxiolysis
Fever reduction
Pain
- Chronic
- Malignancy-related breakthrough pain
- Mild
- Moderate
- Post-operative
- Severe
Reversal of neuromuscular blockage
Sedation
- Initially intubated & mechanically ventilated pediatric subjects in an intensive care setting
Skeletal muscle relaxation to facilitate rapid sequence and routine endotracheal intubation

Congestive heart failure
- heart failure due to systemic left ventricular systolic dysfunction
Dilated Cardiomyopathy (DCM) and symptomatic chronic heart failure
Hypertension
- General
- Post-operative hypertension
Pulmonary hypertension
- Primary/secondary
- Post-surgical
Raynaud's Phenomenon
Tachyarrhythmia

Acromegalic gigantism
Bone mineral density (BMD)
- BMD in anorexia nervosa patients
- BMD in osteogenesis imperfecta patients
- BMD in postmenarcheal adolescents with secondary amenorrhea
Central Precocious Puberty (CPP)
Delayed puberty in boys with primary and secondary hypogonadism
Diabetes Mellitus
- Type 1
- Type 2
Failure to thrive in pediatric AIDS patients
Growth-hormone-secreting lesions of the pituitary gland
Gynecomastia
Homozygous familial hypercholesterolemia (HoFH)
Hypercholesterolemia (heterozygous familial hypercholesterolemia)
Hyperparathyroidism (renal failure secondary to hyperparathyroidism)
Hypocalcemia management in patients on hemodialysis
McCune-Albright Syndrome
Obesity
- General
- Hypothalamic
Osteogenesis Imperfecta (OI)
Tetrahydrobiopterin- (BH4-) responsive phenylketonuria (PKU)
Testotoxicosis

Antiemesis
- Treatment and prevention of nausea and vomiting associated with emetogenic chemotherapy
- Prevention of post-operative nausea and vomiting
Clostridium difficile-associated diarrhea (CDAD)
Constipation (general )
Crohn's Disease
Diarrhea (acute)
Erosive Esophagitis
Gastroesophageal Reflux Disease (GERD)
Irritable Bowel Syndrome (IBS)
- IBS-D
Nephropathic cystinosis
Short Bowel Syndrome (SBS)
Ulcerative Colitis (UC)
Ulcers

Cytomegalovirus (CMV)
Hepatitis B virus (HBV)
- Chronic
Hepatitis C virus (HCV)
- Chronic
Herpes simplex virus (HSV)
Human Immunodeficiency Virus (HIV) infection
- prophylaxis of HIV infection in exposed neonates
- perinatal transmission of HIV infection
Influenza A/B
Perinatal transmission of HIV infection
Symptoms associated with common cold and influenza
Varicella zoster virus (VZV)

Duchene muscular dystrophy
Insomnia in patients with ADHD
Intractable seizures associated with Dravet syndrome
Migraine
Multiple sclerosis (MS)
- Relapsing forms of MS
Narcolepsy
- Cataplexy in narcolepsy
Neuroblastoma
- High-risk refractory or relapsed neuroblastoma” under Neuroblastoma
Seizures
- Generalized
- Lennox-Gastaut Sundrome (LGS)
- Partial
  - with or without secondarily generalized seizures
Spasticity management
Obstructive sleep apnea (OSA) (excessive sleepiness in OSA)
Tourette’s syndrome
- ADHD in patients with Tourette's disorder

Allogeneic bone marrow transplants
Chemotherapy toxicity protection
Chronic Graft Versus Host Disease (GVHD)
CNS malignancies and solid tumors
Giant cell tumor of bone and osteosarcoma
Hematologic tumors
- CNS lymphomas
  - Low grade gliomas
  - High grade gliomas
  - Recurrent, progressive, or refractory brain tumors
- Leukemia
  - Acute lymphoblastic leukemia
  - Acute myelogenous leukemia
  - CNS leukemia
  - Mixed linear acute leukemia
  - Philadelphia positive (Ph+) chronic myelogenous leukemia
- Hodgkin's lymphoma
- Non-Hodgkin's lymphoma
  - Anaplastic large cell lymphoma
  - Mature B-cell NHL
Hematopoietic stem cell mobilization in patients with pediatric malignancies eligible for autologous stem cell transplantation
Melanoma
Myelodysplastic syndromes
Neuroblastoma
Osteosarcoma
Pediatric malignancies
Refractory/relapse malignancies
- advanced relapsed/refractory malignant solid tumors with activation of the RAS/RAF/MEK signaling pathway.
- relapsed or refractory solid tumors containing BRAF V600 activating mutations and in the treatment of adolescent patients with unresectable or metastatic melanoma containing BRAF V600 activating mutations.
- relapsed or refractory tumors with ErbB1 or Erb B2 pathway dysregulation.
- Rhabdomyosarcoma and non-rhabdomyosarcomatous soft tissue sarcoma.

Allergic Rhinitis
Asthma
Bronchopulmonary dysplasia
Bronchospasm (treatment and prevention)
- Prevention of bronchospasm in patients with obstructive airway disease
Cystic Fibrosis

Familial Mediterranean Fever (FMF)
Juvenile Idiopathic Arthritis (JIA)/Juvenile Rheumatoid Arthritis (JRA)
- Polyarticular Juvenile Idiopathic Arthritis (PJIA)
Management of fibromyalgia