Imipenem-cilastatin-relebactam Injection

FDA Identified Breakpoints

	Minimum Inhibitory Concentrations (mcg/mL)			Disk Diffusion a (zone diameter in mm)
Pathogen	S	I	R	S	I	R
Enterobacteriaceae b	≤1/4	2/4	≥4/4	≥25	21-24	≤20
Pseudomonas aeruginosa	≤2/4	4/4	≥8/4	≥23	20-22	≤19
Acinetobacter calcoaceticus-baumannii complex	≤2/4	4/4	≥8/4	-	-	-
Haemophilus influenzae	≤4/4	-	-	-	-	-
Anaerobes c,d	≤4/4	8/4	≥16/4	-	-	-

S = Susceptible; I = Intermediate; R = Resistant

^a For disk diffusion, use paper disks impregnated with imipenem/relebactam at a concentration of 10/25 mcg/mL.
^b Clinical efficacy was shown for Klebsiella aerogenes, Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, Citrobacter freundii, Klebsiella oxytoca.
^c Clinical efficacy was shown for Bacteroides caccae, Bacteroides fragilis, Bacteroides ovatus, Bacteroides stercoris, Bacteroides thetaiotaomicron, Fusobacterium nucleatum, Parabacteroides distasonis.
^d Agar dilution method.