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  1. Development & Approval Process (Drugs)

Daptomycin Injection Products

Daptomycin Injection Products

Recognized Interpretive Criteria

Exception to the recognized standard of CLSI M100

 

Minimum Inhibitory
Concentrations
(mcg/mL)

Disk Diffusion
(zone diameter in mm)

Pathogen

S

I

R

S

I

R

Staphylococcus spp.

M100 standard is recognized

-

-

-

Enterococcus spp.(vancomycin-susceptible isolates only)

<4

-

-

-

-

-

Streptococcus spp β- Hemolytic Group

M100 standard is recognized

-

-

-

Streptococcus spp Viridans Group

M100 standard is recognized

-

-

-

S = Susceptible; I = Intermediate; R = Resistant

STIC are based on a dosing regimen of 6 mg/kg once every 24 h for patients with Creatinine Clearance >30 mL/min