U.S. flag An official website of the United States government
  1. Home
  2. Science & Research
  3. About Science & Research at FDA
  4. FDA Grand Rounds
  5. Studies of SARS-CoV-2 NSP1 and Envelope Protein - 03/11/2021 - 03/11/2021
  1. FDA Grand Rounds

Webcast

Event Title
Studies of SARS-CoV-2 NSP1 and Envelope Protein
March 11, 2021


Date:
March 11, 2021
Time:
12:00 PM - 1:00 PM ET

About the Speaker: 

Marli Azevedo, Ph.D.
Research Biologist, Division of Microbiology
National Center for Toxicological Research (NCTR)

Dr. Marli Azevedo studied pharmacy and clinical biochemistry at the College of Pharmacy, Brazil. She earned a Master of Science in tropical medicine with a focus in virology studying diarrheal diseases affecting HIV patients. She earned a Ph.D. in virus immunology at The Ohio State University in 2005, focusing in vaccine design and enteric virus pathogenesis. From 2005 to 2007, she trained at The Ohio State University as a postdoctoral fellow. In 2007, she attained an academic position as a research scientist and adjunct assistant professor at Food Animal Health Research Program at The Ohio State University. In 2009, she joined the Division of Microbiology at NCTR.

About the Presentation:

To elucidate COVID-19 pathogenesis and develop a successful treatment will require a comprehensive understanding of all SARS-CoV-2 viral proteins. The aim of this study is to understand the role of NSP1 and envelope protein in disease pathogenesis. NSP1 and envelope protein were expressed in HEK293T cells. Induction of high level of NSP1 expression coincided with higher cell death, while under high levels of envelope and nucleocapsid proteins expression, cells remained healthy. Future studies will further explore the role of SARS-CoV-2 NSP1 and envelope protein on intracellular calcium modulation.

Learning Objectives:

  • Describe the SARS-CoV-2 genome organization and its comparison with other Human Coronaviruses.
  • Give a brief overview of SARS-CoV-2 replication cycle.
  • Give a brief overview of SARS-CoV-2 non-structural proteins and their known functions.
  • Provide an in depth overview of NSP1 and envelope protein functions.
  • Describe the effects of NSP1, envelope protein and nucleocapsid expression in HEK293T cells.
  • Explain the role of NSP1 and envelope protein on the intracellular calcium modulation.

To Register:

FDA Employees
https://lms.learning.hhs.gov/Saba/Web/Main/goto/RegisterCatalog?offeringId=class000000000158791&oneClickLearningON=true

Webcast Registration: To register for the webcast, please click the link below and then follow the instructions on the registration page. After registration, you will receive a link via email to access the live webinar. You must log in with the username and password created when you registered. Please pre-register at least one day before the event to ensure you receive the access link email and outlook invitation for the session.
https://collaboration.fda.gov/mar112021/event/registration.html

For technical assistance please contact Sharron.Watson@fda.hhs.gov.  

www.FDA.gov/GrandRounds

 

 

 


 

Back to Top