FDA Grand Rounds Title: Electron Microscopy, Still a Powerful Research Tool
May 11, 2023
- May 11, 2023
- 12:00 PM - 1:00 PM ET
About the Speaker
Dr. Angel M. Paredes
Director of Electron Microscopy
Office of Regulatory Affairs
National Center for Toxicological Research
U.S. Food and Drug Administration
Dr. Angel Paredes has 40 years of experience working with and teaching researchers how to use electron microscopes. He was trained classically in electron microscopy at the University of Texas at Austin where he used Electron Microscope (EM) to study the structure of Sindbis (an alphavirus). Sindbis is a model for other mosquito-borne alphaviruses that cause disease in humans and livestock, and which are responsible for some emerging diseases in the U.S. In 1993, he continued his work on the alphavirus structure at the Baylor College of Medicine at the National Center for Macromolecular Imaging (NCMI) where he was trained in Cryogenic electron microscopy (cryoEM), a powerful new technology used to reconstruct biological macromolecules including viruses. In 2004, he then became manager of a cryoEM facility for the University of Texas Health Science Center where he helped investigators use electron microscopy to further biological research. He joined the FDA in 2011 at the National Center for Toxicological Research (NCTR) where he is presently the Director of Electron Microscopy for the Center and for FDA.
About the Presentation:
Electron microscopy (EM) has exploded with new technological advances and that makes these tools even more valuable in scientific research. The FDA and the public have made investments in these new technologies. We will explore how these instruments work and how they can be used to further agency-relevant research for the FDA scientific community.
- Explain how electron microscopes work.
- Describe the available new EM technologies and instruments.
- Discuss potential contribution of new EM technologies with the future FDA-related research projects.
Activity Announcement for FDA Grand Rounds – May 11, 2023