Research Biologist — Division of Genetic and Molecular Toxicology
Nan Mei, Ph.D.
Dr. Nan Mei received his M.D. in 1984 from the Hebei Medical University in China and his Ph.D. degree in 1997 from the University of Occupational and Environmental Health in Japan. He began his scientific career in clinical cancer research in 1988 at the 4th Hospital of Hebei Medical University in China. He worked as a postdoctoral follow in the Department of Experimental Oncology, Cross Cancer Institute in Canada from 1998 to 2001, and as a research fellow in the Department of Environmental Oncology, Institute of Industrial Ecological Sciences in Japan from 2001 to 2002. He joined NCTR as an ORISE research fellow in the Division of Genetic and Molecular Toxicology in 2002, and became an FDA research biologist in 2005. During his research career, Dr. Mei has published 92 peer-reviewed research articles in scientific journals and 12 book chapters. He has given 32 oral presentations at national and international scientific meetings.
Dr. Mei’s research program is focused on using appropriate in vivo and in vitro mutation assays and toxicogenomic techniques to provide key toxicological information for FDA priority chemicals. He utilizes the 1) in vivo cII transgenic mutation assay (mouse and rat), 2) in vitro standard test battery for genotoxicity, 3) gene expression and pathway analysis to evaluate FDA-relevant chemicals or model carcinogens for their mutagenicity and for determining the mechanisms involved in chemically induced genetic toxicity. His completed and ongoing projects include the evaluation of the mutagenic effects of direct mutagens, herbal dietary supplements, industrial compounds, nanoparticles, ingredients in cosmetics and other retail products, and tobacco products. Dr. Mei has incorporated toxicogenomic approaches into his research to elucidate molecular mechanisms and create gene signatures for developing potential biomarkers. His research results demonstrate that both in vivo and in vitro mutation assays serve as reliable tools for detecting the types of mutations found in cancer genes, and are useful for the hazard identification portion of human risk assessment.
Professional Societies/National and International Groups
Environmental Mutagenesis and Genomics Society (EMGS)
2001 – Present
Transgenic and In Vivo Mutagenesis Special Interest Group
2012 – 2014
Education, Student and New Investigator Affairs Committee
2014 – Present
International Life Sciences Institute/Health and Environmental Sciences Institute
Genetic Toxicology Technical Committee
2016 – Present
Society of Toxicology (SOT)
2003 – Present
South Central Chapter of the Society of Toxicology (SCC-SOT)
2011 – Present
2017 – 2018
Publication titles are linked to text abstracts on PubMed.
Comparative Genotoxicity of TEMPO and 3 of its Derivatives in Mouse Lymphoma Cells.
Guo X., Seo J.E., Bryce S.M., Tan J.A., Wu Q., Dial S.L., Moore M.M., and Mei N.
Toxicol Sci. 2018, 163(1), 214-225.
Quantitative Differentiation of Whole Smoke Solution-Induced Mutagenicity in the Mouse Lymphoma Assay.
Guo X., Heflich R.H., Dial S.L., De M., Richter P.A., and Mei N.
Environ Mol Mutagen. 2018, 59(2), 103-113.
ROS Generation and JNK Activation Contribute to 4-Methoxy-TEMPO-Induced Cytotoxicity, Autophagy, and DNA Damage in HepG2 Cells.
Zhang Z., Ren Z., Chen S., Guo X., Liu F., Guo L., and Mei N.
Arch Toxicol. 2018, 92(2), 717-728.
Review of Ginkgo Biloba-Induced Toxicity, from Experimental Studies to Human Case Reports.
Mei N., Guo X., Ren Z., Kobayashi D., Wada K., and Guo L.
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2017, 35(1), 1-28.
Aloe Vera: A Review of Toxicity and Adverse Clinical Effects.
Guo X., and Mei N.
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2016, 34(2): 77-96.
Quantitative Analysis of In Vitro Mutagenicity Induced by Five Chemical Constituents of Tobacco Smoke.
Guo X., Dial S.L., Heflich R.H., Richter P.A., Moore M.M., and Mei N.
Mutagenesis. 2016, 31: 287–296.
Ginkgo biloba Leaf Extract Induces DNA Damage by Inhibiting Topoisomerase II Activity in Human Hepatic Cells.
Zhang Z., Chen S., Mei H., Xuan J., Guo X., Couch L., Dobrovolsky V.N., Guo L., and Mei N.
Scientific Reports. 2015, 5: 14633.
Neonatal Exposure of 17β-Estradiol has No Effects on Mutagenicity of 7,12-Dimethylbenz[A]Anthracene in Reproductive Tissues of Adult Mice.
Zhang Z., Li H., Manjanatha M.G., Chen T., and Mei N.
Genes and Environment. 2015, 37: 16.
Reactive Oxygen Species and C-Jun N-Terminal Kinases Contribute to TEMPO-Induced Apoptosis in L5178Y Cells.
Guo X., Chen S., Zhang Z., Dobrovolsky V.N., Dial S.L., Guo L., and Mei N.
Chem Biol Interact. 2015, 235: 27-36.
In vitro Investigation of the Mutagenic Potential of Aloe Vera Extracts.
Guo X., Zhang S., Dial S.L., Boudreau M.D., Xia Q., Fu P.P., Levy D.D., Moore M.M., and Mei N.
Toxicology Research. 2014, 3: 487-496.
Contact information for all lab members:
Stacey L. Dial
- Contact Information
- Nan Mei
- (870) 543-7391