National Center for Toxicological Research Also referred to as: NCTR

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Mission

Address FDA’s needs with high-quality research and serve as a global resource for collaboration, training, and innovative scientific solutions.

Vision

Conduct scientific research to provide reliable data for FDA’s decision-making and develop innovative tools and approaches that support FDA’s public health mission. 

 

NCTR Celebrates 50 Years of Scientific Achievement

The National Center for Toxicological Research (NCTR), is the only FDA Center located outside the Washington D.C. metropolitan area. The one-million square foot research campus in Jefferson, Arkansas plays a critical role in the missions of FDA and the Department of Health and Human Services to promote and protect public health. 

Regulatory science researchers, academia, and other regulatory science research organizations and groups from around the world investigate, learn, and train at the Federal facility. NCTR, FDA's internationally recognized research center, plays a critical role in FDA’s mission.  The unique scientific expertise of NCTR is critical in supporting FDA product centers and their regulatory roles. 

 

NCTR Jefferson Labs Campus

NCTR:

• Provides interdisciplinary toxicology research solutions and consultations that support and anticipate future FDA needs to guard and improve personal and public health.
• Uses multidisciplinary research teams to develop novel translational research approaches for safety-assessment protocols that provide FDA with more accurate and economic methods for addressing regulatory questions.
• Engages in collaborations with scientists across FDA and other government agencies, industry, and academia to strengthen the scientific foundations vital to developing sound regulatory policy, and to promote the international standardization and global harmonization of regulatory science.
• Develops—or participates in—national and international consortia that provide harmonized standards for technologies and risk-evaluation methods vital to FDA’s regulatory and public-health mission.
• Provides and encourages multidisciplinary workforce development, and fosters national and international collaborations with scientists from government, academia, and industry.

About NCTR Research 

• Annual Report

• Research Divisions

• Research Focus Areas

• Research Publications

About NCTR's Bioinformatics Tools

• ArrayTrack™ HCA-PCA Standalone Package

• Database of Pharmacogenomic Information in Ethnic Minority Populations (dbPGxEMP)

• de novo Assembly Quality Evaluation Tool (dnAQET)

• Decision Forest

• Estrogenic Activity Database (EADB)

• Endocrine Disruptor Knowledge Base (EDKB)

• FDALabel – An FDA Drug Labeling Search Tool

• Liver Toxicity Knowledge Base (LTKB)

  • Drug-Induced Liver Injury Rank (DILIrank) Dataset

  • Drug-Induced Liver Injury Severity and Toxicity (DILIst) Dataset

• MicroArray/Sequencing Quality Control (MAQC/SEQC)

• Mold2

About NCTR's Organization

• Contact NCTR

• Organization Chart

More About NCTR

• NCTR Informational Brochure

• Jobs and Training Opportunities at NCTR

• FDA-TRACK: National Center for Toxicological Research

• NCTR Science Advisory Board Committee

• NCTR FOIA Electronic Reading Room

• Environmental Assessment for Jefferson Labs Campus Development Project

Resources For You

• Get E-mail Updates About NCTR
• Notice to NCTR Employees

Spotlight 

• Meet Tucker Patterson, Ph.D., Center Director, National Center for Toxicological Research
• FDA Voices: "FDA’s National Center for Toxicological Research Celebrates Half a Century of Cutting-Edge Research"
• FDA's Predictive Toxicology Roadmap
• FDA's 2018 Strategic Policy Roadmap

NCTR News and Awards

NCTR Article Received EMM Editor's Choice

The Environmental Mutagenesis and Genomics Society has selected an NCTR article, “CD59-Deficient Bone Marrow Erythroid Cells From Rats Treated With Procarbazine and Propyl-Nitrosourea Have Mutations In The Pig-a Gene," as “Editor’s Choice.” The article was highlighted on the cover of the October 2020 issue of Environmental and Molecular Mutagenesis.

NCTR Scientists Awarded "Toxicological Sciences Paper of the Year"

SOT's “Toxicological Sciences Paper of the Year,” has been awarded to researchers in NCTR's Division of Biochemical Toxicology. "Gene Expression and DNA Methylation Alterations in the Glycine N-Methyltransferase Gene in Diet-Induced Nonalcoholic Fatty Liver Disease-Associated Carcinogenesis" was selected by the SOT Board of Publications and presented at the annual meeting.

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