Conduct scientific research to provide reliable data for FDA’s decision-making and develop innovative tools and approaches that support FDA’s public health mission.
Addressing FDA’s needs with high-quality research and by serving as a global resource for collaboration, training, and innovative scientific solutions.
The National Center for Toxicological Research (NCTR), is the only FDA Center located outside the Washington D.C. metropolitan area. The one-million square foot research campus in Jefferson, Arkansas plays a critical role in the missions of FDA and the Department of Health and Human Services to promote and protect public health.
Regulatory science researchers, academia, and other regulatory science research organizations and groups from around the world investigate, learn, and train at the Federal facility. NCTR, FDA's internationally recognized research center, plays a critical role in FDA’s mission. The unique scientific expertise of NCTR is critical in supporting FDA product centers and their regulatory roles.
- Provides interdisciplinary toxicology research solutions and consultations that support and anticipate future FDA needs to guard and improve personal and public health.
- Uses multidisciplinary research teams to develop novel translational research approaches for safety-assessment protocols that provide FDA with more accurate and economic methods for addressing regulatory questions.
- Engages in collaborations with scientists across FDA and other government agencies, industry, and academia to strengthen the scientific foundations vital to developing sound regulatory policy, and to promote the international standardization and global harmonization of regulatory science.
- Develops—or participates in—national and international consortia that provide harmonized standards for technologies and risk-evaluation methods vital to FDA’s regulatory and public-health mission.
- Provides and encourages multidisciplinary workforce development, and fosters national and international collaborations with scientists from government, academia, and industry.
About NCTR Research
About NCTR's Bioinformatics Tools
About NCTR's Organization
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Resources For You
- Meet William Slikker, Jr., Ph.D., Director, National Center for Toxicological Research
- FDA Voices: "FDA’s National Center for Toxicological Research Celebrates Half a Century of Cutting-Edge Research"
- FDA's Predictive Toxicology Roadmap
- FDA's 2018 Strategic Policy Roadmap
NCTR Article Received EMM Editor's Choice
The Environmental Mutagenesis and Genomics Society has selected an NCTR article, “CD59-Deficient Bone Marrow Erythroid Cells From Rats Treated With Procarbazine and Propyl-Nitrosourea Have Mutations In The Pig-a Gene," as “Editor’s Choice.” The article was highlighted on the cover of the October 2020 issue of Environmental and Molecular Mutagenesis.
NCTR Scientists Awarded "Toxicological Sciences Paper of the Year"
SOT's “Toxicological Sciences Paper of the Year,” has been awarded to researchers in NCTR's Division of Biochemical Toxicology. "Gene Expression and DNA Methylation Alterations in the Glycine N-Methyltransferase Gene in Diet-Induced Nonalcoholic Fatty Liver Disease-Associated Carcinogenesis" was selected by the SOT Board of Publications and presented at the annual meeting.
- National Center for Toxicological Research
Food and Drug Administration
3900 NCTR Rd
Jefferson, AR 72079
- (870) 543-7121