Senior Staff Fellow — Division of Biochemical Toxicology
Luísa Camacho, Ph.D.
Luísa Camacho received a bachelor’s in applied plant biology from the Faculty of Sciences of the University of Lisbon, Portugal in 1998, and a Ph.D. in cell biology from the University of Lisbon, Portugal in 2003. She was a research associate at the School of Biological and Biomedical Sciences of the University of Durham, UK between 2003 and 2005. She was an academic visitor at the Department of Plant Sciences of the University of Oxford, UK between 2005 and 2007. In 2007, Dr. Camacho joined NCTR’s Division of Biochemical Toxicology as a postdoctoral fellow; she converted to an FDA Staff Fellow in 2009. Dr. Camacho has published over 25 research articles and book chapters. She is a member of the editorial board for the journal Data in Brief and has served as a reviewer for more than 25 scientific journals.
Dr. Camacho’s group conducts toxicological studies in animal models to assess the toxicity of products of interest to FDA. A particular focus has been on compounds with endocrine activity and on toxicological studies that include exposures during the perinatal period of life. In addition to the traditional toxicological endpoints, she assesses molecular endpoints using biological samples collected from the same animals. This complementary effort contributes to a better understanding of the molecular mechanisms by which the compounds may act and helps identify potential novel biomarkers of toxicity. Many of these studies are conducted under the sponsorship of the National Toxicology Program (NTP) and/or conducted in collaboration with colleagues from other divisions at NCTR and from the FDA product centers. Dr. Camacho has multiple major research interests. The first of these is CLARITY-BPA (Consortium Linking Academic and Regulatory Insights on Bisphenol A Toxicity), a collaborative research program that involves staff from FDA (NCTR and Center for Food Safety and Applied Nutrition), National Institute of Environmental Health Sciences (Division of Extramural Research and Training and NTP), and 13 university-based researchers. Next, there is the characterization of the fibrinolytic activity of the dietary supplements nattokinase and lumbrokinase in vitro and assessment of their toxicological effects, either individually or in combination with aspirin, in vivo using a rat model. Finally, Dr. Camacho retains an interest in comparison of the dose-response and temporal dynamics of traditional (blood urea nitrogen and serum creatinine) and novel (serum microRNAs) biomarkers of nephrotoxicity upon a combined exposure to melamine and cyanuric acid in rats.
Professional Societies/National and International Groups
Data in Brief, Elsevier
Member, Editorial Board
2015 – Present
Reproductive and Developmental Toxicology Specialty Section of the Society of Toxicology
2013 – Present
Research Grants Council of Hong Kong, China
2015 – Present
Society of Toxicology
2007 – Present
Women in Toxicology Special Interest Group of the Society of Toxicology
Effects of a 28-Day Dietary Co-Exposure to Melamine and Cyanuric Acid on the Levels of Serum microRNAs in Male and Female Fisher 344 Rats.
Silva C., Chang C., Williams D., Porter-Gill P., Gamboa da Costa G. and Camacho L.
Food Chem Toxicol. 2016 Sep 9, pii: S0278-6915(16)30328-3.
Comparison of Endpoints Relevant to Toxicity Assessments in 3 Generations of CD-1 Mice Fed Irradiated Natural and Purified Ingredient Diets with Varying Soy Protein, Isoflavone, and Thiamine Contents.
Camacho L., Lewis S., Vanlandingham M., Juliar B., Olson G., Patton R., Gamboa da Costa G., Woodling K., Sepehr E., Bryant M., Doerge D., Basavarajappa M., Felton R. and Delclos K.
Food Chem Toxicol. 2016 Aug, 94:39-56.
Effects of Developmental Exposure to Bisphenol A on Spatial Navigational Learning and Memory in Rats: a CLARITY-BPA Study.
Johnson S., Javurek A., Painter M., Ellersieck M., Camacho L., Lewis S., Vanlandingham M., Ferguson S. and Rosenfeld C.
Horm Behav. 2016 Apr, 80:139-48.
Impact of Low Dose Oral Exposure to Bisphenol A (BPA) on Juvenile and Adult Rat Exploratory and Anxiety Behavior: a CLARITY-BPA Consortium Study.
Rebuli M., Camacho L., Adonay M., Reif D., Aylor D. and Patisaul H.
Toxicol Sci. 2015 Dec, 148(2):341-54.
NIEHS/FDA CLARITY-BPA Research Program Update.
Heindel J., Newbold R., Bucher J., Camacho L., Delclos K., Lewis S., Vanlandingham M., Churchwell M., Twaddle N., McLellen M., Chidambaram M., Bryant M., Woodling K., Gamboa da Costa G., Ferguson S., Flaws J., Howard P., Walker N., Zoeller R., Fostel J., Favaro C. and Schug T.
Reprod Toxicol. 2015 Dec, 58:33-44.
Effects of Oral Exposure to Bisphenol A on Gene Expression and Global Genomic DNA Methylation in the Prostate, Female Mammary Gland, and Uterus of NCTR Sprague-Dawley Rats.
Camacho L., Basavarajappa M., Chang C., Han T., Kobets T., Koturbash I., Surratt G., Lewis S., Vanlandingham M., Fuscoe J., Gamboa da Costa G., Pogribny I. and Delclos K.
Food Chem Toxicol. 2015 Jul, 81:92-103.
Investigation of the Effects of Subchronic Low Dose Exposure to Bisphenol A (BPA) on Estrogen Receptor Expression in the Juvenile and Adult Female Rat Hypothalamus.
Rebuli M., Cao J., Sluzas E., Delclos K., Camacho L., Lewis S., Vanlandingham M. and Patisaul H.
Toxicol Sci. 2014 Jul, 140(1):190-203.
Comparison of Lifestage-Dependent Internal Dosimetry for Bisphenol A, Ethinyl Estradiol, a Reference Estrogen, and Endogenous Estradiol to Test an Estrogenic Mode of Action in Sprague-Dawley Rats.
Churchwell M., Camacho L., Vanlandingham M., Twaddle N., Sepehr E., Delclos K., Fisher J. and Doerge D.
Toxicol Sci. 2014 May, 139(1):4-20.
Toxicity Evaluation of Bisphenol A Administered by Gavage to Sprague-Dawley Rats from Gestation Day 6 Through Postnatal Day 90.
Delclos K., Camacho L., Lewis S., Vanlandingham M., Latendresse J., Olson G., Davis K., Patton R., Gamboa da Costa G., Woodling K., Bryant M., Chidambaram M., Trbojevich R., Juliar B., Felton R. and Thorn B.
Toxicol Sci. 2014 May, 139(1):174-97.
A New Approach to Synergize Academic and Regulatory-Compliant Research: the CLARITY-BPA Research Program.
Schug T., Heindel J., Camacho L., Delclos K., Howard P., Johnson A., Aungst J., Keefe D., Newbold R., Walker N., Zoeller R. and Bucher J.
Reprod Toxicol. 2013 Sep, 40:35-40.
Comparison of the Global Gene Expression of Choroid Plexus and Meninges and Associated Vasculature Under Control Conditions and After Pronounced Hyperthermia or Amphetamine Toxicity.
Bowyer J., Patterson T., Saini U., Hanig J., Thomas M., Camacho L., George N. and Chen J.
BMC Genomics. 2013 Mar 5, 14:147.
The Estrogenic Content of Rodent Diets, Bedding, Cages and Water Bottles and Its Impact on Bisphenol A Studies.
Thigpen J., Setchell K., Kissling G., Locklear J., Caviness G., Whiteside T., Belcher S., Brown N., Collins B., Lih F., Tomer K., Padilla-Banks E., Camacho L., Adsit F., Grant M. and Forsythe D.
J Am Assoc Lab Anim Sci. 2013 Mar, 52(2):130-41.
Performance of Urinary and Gene Expression Biomarkers in Detecting the Nephrotoxic Effects of Melamine and Cyanuric Acid Following Diverse Scenarios of Co-Exposure.
Bandele O., Camacho L., Ferguson M., Reimschuessel R., Stine C., Black T., Olejnik N., Keltner Z., Scott M., Gamboa da Costa G. and Sprando R.
Food Chem Toxicol. 2013 Jan, 51:106-13.
Effects of Acrylamide Exposure on Serum Hormones, Gene Expression, Cell Proliferation, and Histopathology in the Testes of Fischer 344 Rats.
Camacho L., Latendresse J., Muskhelishvili L., Bowyer J., Thomas M. and Doerge D.
Toxicol Lett. 2012 Jun 1, 211(2):135-43.
Gene Expression of Biomarkers of Nephrotoxicity in F344 Rats Co-Exposed to Melamine and Cyanuric Acid for Seven Days.
Camacho L., Kelly K., Beland F. and Gamboa da Costa G.
Toxicol Lett. 2011 Oct 10, 206(2):166-71.
Camila S. Silva, Ph.D.
- Contact Information
- Luísa Camacho
- (870) 543-7391
ExpertiseApproachDomainTechnology & DisciplineToxicology