Research Biologist — Division of Biochemical Toxicology
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Lei Guo, Ph.D.
Lei Guo received a Ph.D. degree in molecular biology from the University of Tokyo (Japan) in 1998, and worked as a Postdoctoral Fellow and then as a Research Assistant Professor at the University of Alberta (Canada) for four years. Dr. Guo joined NCTR in 2003. He has published 82 articles in peer-reviewed journals and 11 book chapters. Her work has been cited more than 4000 times, and she has an H-index of 30.
Dr. Guo's research focuses on mechanistic studies of drug (and herbal dietary supplement) associated toxicities. She utilizes multiple approaches, including, but not restricted to, molecular and biochemical methods, genomic analyses, and in silico molecular docking for the evaluation and prediction of toxicity and for the elucidation of toxic mechanisms. Her research results demonstrate that this combined approach is useful for hazard identification and that in-depth molecular mechanistic studies can provide toxicological information for FDA relevant-products. Dr. Guo has also developed in vitro methods to assess liver toxicity and for mechanistic investigations.
Professional Societies/National and International Groups
The South Central Chapter of the Society of Toxicology
2011 - Present
Activation of the Nrf2 Signaling Pathway in Usnic Acid-Induced Toxicity in HepG2 Cells
Chen S., Zhang Z., Qing T., Ren Z., Yu D., Couch L., Ning B., Mei N., Shi L., Tolleson W. and Guo L.
Arch Toxicol. 2016, in press.
The Role of CYP 3A4 and 1A1 in Amiodarone-Induced Hepatocellular Toxicity
Wu Q., Ning B., Xuan J., Ren Z., Guo L. and Bryant M.
Toxicol Lett. 2016, 253:55-62.
Endoplasmic Reticulum Stress and Store-Operated Calcium Entry Contribute to Usnic Acid-Induced Toxicity in Hepatic Cells
Chen S., Zhang Z., Wu Y., Shi Q., Yan H., Mei N., Tolleson W. and Guo L.
Toxicol Sci. 2015, 146:116-126.
Development of HepG2-Derived Cells Expressing Cytochrome P450s for Assessing Metabolism-Associated Drug-Induced Liver Toxicity
Xuan J., Chen S., Ning B., Tolleson W. and Guo L.
Chem Biol Interact. 2016, 5: 63-73.
Ginkgo Biloba Leaf Extract Induces DNA Damage by Inhibiting Topoisomerase II Activity in Human Hepatic Cells
Zhang Z., Chen S., Mei H., Xuan J., Guo X., Couch L., Dobrovolsky V., Guo L. and Mei N.
Sci Rep. 2015, 5:14633.
The Role of Autophagy in Usnic Acid-Induced Toxicity in Hepatic Cells
Chen S., Dobrovolsky V., Liu F., Wu Y., Zhang Z., Mei N. and Guo L.
Toxicol Sci. 2014, 142:33-44.
Endoplasmic Reticulum Stress in Drug- And Environmental Toxicant-Induced Liver Toxicity
Chen S., Melchior W. and Guo L.
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2014, 32:83-104.
Sertraline Induces Endoplasmic Reticulum Stress in Hepatic Cells
Chen S., Xuan J., Couch L., Iyer A., Wu Y., Li Q. and Guo L.
Toxicology. 2014, 322C:78-88.
Sertraline, an Antidepressant, Induces Apoptosis in Hepatic Cells through the Mitogen-Activated Protein Kinase Pathway
Chen S., Xuan J., Wan L., Lin H., Couch L., Mei N., Dobrovolsky V. and Guo L.
Toxicol Sci. 2014, 137:404-415.
Mechanism Study of Goldenseal-Associated DNA Damage
Chen S., Wan L., Couch L., Lin H., Li Y., Dobrovolsky V., Mei N. and Guo L.
Toxicol Lett. 2013, 221:64-72.
Mitochondrial Dysfunction Induced by Sertraline, an Antidepressant Agent
Li Y., Couch L., Higuchi M., Fang J. and Guo L.
Toxicol Sci. 2012, 127:582-591.
Similarities and Differences in the Expression of Drug-Metabolizing Enzymes between Human Hepatic Cell Lines and Primary Human Hepatocytes
Guo L., Dial S., Shi L., Branham W., Liu J., Fang J., Green B., Deng H., Kaput J. and Ning B.
Drug Metab Dispos. 2011, 39:528-538.
Methysticin and 7,8-Dihydromethysticin Are Two Major Kavalactonesin Kava Extract to Induce CYP1A1
Li Y., Mei H., Wu Q., Zhang S., Fang J., Shi L. and Guo L.
Toxicol Sci. 2011, 124:388-399.
Ginkgo Biloba Extract Induces Gene Expression Changes in Xenobiotics Metabolism and the Myc-Centered Network
Guo L., Mei N., Liao W., Chan P. and Fu P.
OMICS. 2010, 14:75-90.
Gene Expression Profiling in Male B6C3F1 Mouse Livers Exposed to Kava Identifies--Changes in Drug Metabolizing Genes and Potential Mechanisms Linked to Kava Toxicity
Guo L., Shi Q., Dial S., Xia Q., Mei N., Li Q., Chan P. and Fu P.
Food Chem Toxicol. 2010, 48:686-696.
Analysis of Gene Expression Changes of Drug Metabolizing Enzymes in the Livers of F344 Rats Following Oral Treatment with Kava Extract
Guo L., Li Q., Xia Q., Dial S., Chan P. and Fu P.
Food Chem Toxicol. 2009, 47:433-442.
Systematic and Simultaneous Gene Profiling of 84 Drug-Metabolizing Genes in Primary Human Hepatocytes
Ning B., Dial S., Sun Y., Wang J., Yang J. and Guo L.
J Biomol Screen. 2008, 13:194-201.
Review of Usnic Acid and Usnea Barbata Toxicity
Guo L., Shi Q., Fang J., Mei N., Ali A., Lewis S., Leakey J. and Frankos V.
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2008, 26(4):317-38
Rat Toxicogenomic Study Reveals Analytical Consistency Across Microarray Platforms
Guo L., Lobenhofer E., Wang C., Shippy R., Harris S., Zhang L., Mei N., Chen T., Herman D., Goodsaid F., Hurban P., Phillips K., Xu J., Deng X., Sun Y., Tong W., Dragan Y. and Shi L.
Nat Biotechnol. 2006, 24:1162-1169.
Differences in Hepatotoxicity and Gene Expression Profiles by Anti-Diabetic PPAR Gamma Agonists on Rat Primary Hepatocytes and Human HepG2 Cells
Guo L., Zhang L., Sun Y., Muskhelishvili L., Blann E., Dial S., Shi L., Schroth G. and Dragan Y.
Mol Divers. 2006, 10:349-360.
Contact information for all lab members:
Si Chen, Ph.D.
FDA Staff Fellow
Zhen Ren, Ph.D.
ORISE Postdoctoral Fellow
- Contact Information
- Lei Guo
- (870) 543-7391