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  8. Jinghai Yi
  1. Science & Research (NCTR)

Jinghai Yi Ph.D.
Leadership Role

Staff Fellow — Division of Biochemical Toxicology

Dr. Jinghai Yi

Jinghai Yi, Ph.D.
(870) 543-7121

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About  |  Publications | Lab Members


Dr. Jinghai Yi received B.A., M.S., and Ph.D. degrees in energy and power engineering from Xi’an Jiaotong University in Xi’an, China. After graduating, he worked for the Power Machinery Engineering Department of Shanghai Jiaotong University in Shanghai, China, as a lecturer and postdoctoral fellow. He continued his research in the Mechanical Engineering School at Technion-Israel Institute of Technology and Purdue University and in the Petroleum Engineering Department at Louisiana State University. In 2001, he was hired as a mechanical engineer at Doty Scientific before joining BioTechPlex as a senior mechanical engineer. In 2007, Dr. Yi was hired as a senior inhalation engineer for the Technical Research Institute, a subsidiary of Illinois Institute of Technology (IIT) Research Institute. The Research Institute operates the Inhalation Facility and Animal Facility at Philip Morris. Dr. Yi then became a research assistant professor and inhalation engineer at West Virginia University before he joined the FDA as a mechanical engineer in 2017. Dr. Yi is a staff fellow and senior inhalation toxicologist in the Center for Tobacco Products (CTP)/National Center for Toxicological Research (NCTR) Inhalation Toxicology Core Facility, Division of Biochemical Toxicology.

Dr. Yi received a National Institutes of Health (NIH) Small Business Innovation Research (SBIR) grant and an NIH National Institute for Occupational Safety and Health (NIOSH) subcontract. He was also awarded the Lila Albin Paper Award for 2017 (co-author) and has been awarded two U.S. patents and one Chinese patent.

Research Interests

Dr. Yi’s research interests include 1) inhalation toxicology, 2) aerosol generation and characterization, and 3) design, fabrication, setup, validation, and operation of whole-body and nose-only inhalation exposure systems. He conducts inhalation studies in collaboration with CTP to characterize and quantify the health risk associated with selected chemicals found in tobacco products.

Dr. Yi’s awards and research projects are listed below.

  • Lila Albin Paper Award for 2017 (co-author)
  • Principle Investigator (PI), “Support and Infrastructure for Center for Tobacco Products/NCTR Inhalation Facility,” FDA Center for Tobacco Products, 10/2017- 09/30/2023
  • PI, “A 5-Day Nose-Only Nicotine Inhalation Toxicity Pilot Study in Sprague-Dawley Rats,” FDA Center for Tobacco Products, 11/2021-2022
  • PI, “Pharmacokinetic Analysis of Nicotine in Sprague-Dawley Rats,” FDA Center for Tobacco Products, 11/2017-ongoing
  • Consultant of a NIH SBIR grant, “Aerosol Delivery of Surfactant for ARDS,” Grant Number: 1R43HL127834-01, 09/2015-05/2016 (PI: Yeates)
  • PI of a NIOSH contract, “Inhalation Facility of Desktop 3D Printer Emissions,” Contract Number: 212-2015-M-63382, 08/2015-08/2016
  • Co-investigator of a NIOSH contract, “Cardiovascular Effect of Desktop 3D Printer Emissions,” 08/2015-08/2016
  • PI of a NIH SBIR grant, “Ultra-High Dose Rate Aerosol Drug Delivery,” Grant Number: R43HL078281-01, 12/2004-12/2005
  • Co-investigator of a NIH SBIR grant, “Concentrated Aerosol Delivery and Quantization System,” 09/2001-07/2004. (PI: Yeates).
  • Co-investigator of a NIH SBIR grant, “Water and Ion Measurement System,” Grant Number: 5R44HL067008, (PI: Wong)
  • Co-investigator of a NIH SBIR grant, Grant Number: 2R44RR015150-02A1 (PI: Mao)

Professional Societies/National and International Groups

Society of Toxicology
2009 – 2014

Selected Publications 

Particle and Organic Vapor Emissions from Children’s 3-D Pen and 3-D Printer Toys.
Yi J., Duling M.G., Bowers L.N., Knepp A.K., Lebouf R.F., Nurkiewicz T.R., Ranpara A., Luxton T., Martin S.B., Burns D.A., Peloquin D.M., Baumann E.J., Virji M.A., and Stefaniak A.B.
Inhalation Toxicology. 2019, 31 (13-14) 432-445.

Fluidic and Thermal Properties of Heliox Enable the Efficient Generation and Delivery of High Concentrations of Solid-Phase Fine Particle Aerosols from Viscous Liquids.
Heng X., Yi J., and Yeates D.B.
Aerosol Science and Technology. 2019, 53:6, 609-629.

Estrous Cycle-Dependent Modulation of In Vivo Microvascular Dysfunction After Nanomaterial Inhalation.
Stapleton P., McBride C., Yi J., Abukabda A., and Nurkiewicz T.
Reproductive Toxicology 78. 2018, DOI: 10.1016/j.reprotox.2018.03.001.

Maternal Engineered Nanomaterial Inhalation During Gestation Alters the Fetal Transcriptome.
Stapleton P., Hathaway Q., Nichols C., Abukabda A., Pinti M., Shepherd D., McBride C., Yi J., Castranova V., Nurkiewicz T., and Hollander J.
Particle and Fibre Toxicology. 2018, 15:3 DOI 10.1186/s12989-017-0239-8.

Reactive Oxygen Species Damage Drives Cardiac and Mitochondrial Dysfunction Following Acute Nano-Titanium Dioxide Inhalation Exposure.
Nichols C., Shepherd D., Thapa D., Yi J., Dabkowski E., Nurkiewicz T., and Hollander J.
Nanotoxicology. 2017.

Maternal Engineered Nanomaterial Exposure in Growing Progeny.
Hathaway Q., Nichols C., Shepherd D., Stapleton P., McLaughlin S., Stricker J., Rellick S., Pinti M., Abukabda A., McBride C.,  Yi J., Stine S., Nurkiewicz T., and Hollander J. 
The FASEB Journal. 2017, vol. 31  no. 1 Supplement  843.3.

Heterogeneous Vascular Bed Responses to Pulmonary Titanium Dioxide Nanoparticle Exposure.
Abukabda A., Stapleton P., McBride C., Yi J., and Nurkiewicz T. 
Front Cardiovasc Med. 2017, 4: 33.  https://doi.org/10.3389/fcvm.2017.00033.

Characterization of Chemical Contaminants Generated by a Desktop Fused Deposition Modeling 3-Dimensional Printer.
Stefaniak A., LeBouf R., Yi J.,Duling M., Nurkewicz T., Schwegler-Berry D., Chen B., and Virji A.
Journal of Occupational and Environmental Hygiene. 2017, 25:0. doi: 10.1080/15459624.2017.1302589.

Maternal Engineered Nanomaterial Exposure Disrupts Progeny Cardiac Function and Bioenergetics.
Hathaway Q., Nichols C., Shepherd D., Stapleton P., McLaughlin S., Stricker J., Rellick S., Pinti M., Abukabda A., McBride C., Yi J., Stine S., Nurkiewicz T., and Hollander J.
American Journal of Physiology - Heart and Circulatory Physiology. 2017, DOI: 10.1152/ajpheart.00634.2016.

Emission of Particulate Matter From a Desktop Three-Dimensional (3D) Printer.
Yi J., LeBouf R., Duling M., Nurkiewicz T., Chen B., Schwegler-Berry D., Virji M., and Stefaniak, A.
Journal of Toxicology and Environmental Health. 2016, Part A. DOI: 10.1080/15287394.2016.1166467.

Impacts of Prenatal Nanomaterial Exposure on Male Adult Sprague-Dawley Rat Behavior and Cognition.
Engler-Chiurazzi E., Stapleton P., Stalnaker J., Rambo-Hernandez K., Sarkar S., Jun S., Quintana D., Ren X., Hu H., Nurkiewicz T., McBride C., Yi J., and Simpkins J.
Journal of Toxicology and Environmental Health. 2016, 447-452.

Comparative Plasma Proteomic Studies of Pulmonary TiO2 Nanoparticle Exposure in Rats Using Liquid Chromatography Tandem Mass Spectrometry.
Maurer M., Donohoe G., Maleki H., Yi J., McBride C., Nurkiewicz T., and Valentine S.
J Proteomics. 2016, 130:85-93.

Uterine Microvascular Sensitivity to Nanomaterial Inhalation: an In Vivo Assessment.
Stapleton P., McBride C., Yi J., and Nurkiewicz, T.
Toxicol Appl Pharmacol. 2015, 288(3):420-8. doi: 10.1016/j.taap.2015.08.013.

Microvascular and Mitochondrial Dysfunction in the Female F1 Generation After Gestational TiO2 Nanoparticle Exposure.
Stapleton P., Nichols C., Yi J., McBride C., Minarchick V., Shepherd D., Hollander J., and Nurkiewicz T.
Nanotoxicology. 2015, Volume 9, Issue 8, pages 941-951.

A New Ion Mobility – Linear Ion Trap Instrument for Complex Mixture Analysis.
Donohoe G., Maleki H., Arndt J., Khakinejad M., Yi J., McBride C., Nurkiewicz T., and Valentine S.
Analytical Chemistry. 2014.

Whole-Body Nanoparticle Aerosol Inhalation Exposures.
Yi J., Chen B., Schwegler-Berry D., Frazer D., Castranova V., McBride C., Knuckles T., Stapleton P., Minarchick V., and Nurkiewicz T.
J. Vis. Exp. 2013, (75), e50263. doi:10.3791/50263.

Does the Barker Hypothesis Apply to Maternal Engineered Nanomaterial Exposure and Fetal Microvascular Function?
Stapleton P., Minarchick V., Yi J., Engels K., McBride C., and Nurkiewicz T.
American Journal of Obstetrics and Gynecology. 2013, PMID: 23643573.

Nanoparticle Inhalation Alters Arteriolar Vasoreactivity through Sympathetic and Cyclooxygenase-Mediated Pathways.
Knuckles T., Yi J., Frazer D., Leonard H., Chen B., Castranova V., and Nurkiewicz T.
Nanotoxicology. 2012, 6(7): 724-735. PMID: 21830860.

Dispersion of a Particle-laden Air Jet in a Confined Rectangular Crossflow.
Yi J. and Plesniak M.
Powder Technology. 2002, Vol. 125, pp. 168-178.

Lab Members

Contact information for all lab members:
(870) 543-7121

Seonggi Min, Ph.D.
Staff fellow

Gregory Pellar, Ph.D.
Staff fellow

Yunan Tang, Ph.D., DABT
Staff fellow

Qiangen Wu, Ph.D., DABT
Staff fellow

Dong-Jin Yang, MS
Staff fellow

Contact Information
Jinghai Yi
(870) 543-7121
Technology & Discipline
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