Toxicologist — Division of Biochemical Toxicology
Yunan Tang, Ph.D., DABT
Dr. Yunan Tang studied laboratory medicine at the West China University of Medical Sciences (WCUMS) and graduated in 1991. He then earned his M.S. degree in hygienic toxicology and his Ph.D. in nutrition and food hygiene at WCUMS in 1999 and 2003 respectively. He was first engaged in toxicological laboratory research work at WCUMS between 1985 and 2003. Dr. Tang then did his postdoctoral training at Peking University (2003-2005) and at the University of North Carolina at Chapel Hill (2005 to 2006). He was employed as a senior research associate scientist at the University of Louisville in Kentucky from 2007 to 2013. Dr. Tang has been a board-certified toxicologist since 2012 and joined NCTR as a toxicologist in 2013.
Dr. Tang conducts inhalation studies in collaboration with FDA’s Center for Tobacco Products (CTP) to characterize and quantify the health risk associated with selected chemicals found in cigarette smoke. Tobacco smoke contains more than 7,000 chemical compounds including over 70 that are known to cause cancer. Currently it is estimated that 19.3% of adults in the United States smoke cigarettes, and that 480,000 people die prematurely each year from tobacco-related disease in the United States. CTP was formed following the mandates of the 2009 Family Smoking Prevention Tobacco Control Act. The Act provides a broad authority to regulate the manufacturing, distribution, and marketing of tobacco products.
American Society for Nutrition
2006 – Present
Society of Toxicology
2007 – Present
Publication titles are linked to text abstracts on PubMed.
CCR7 Maintains Non-Resolving Lymph Node and Adipose Inflammation in Obesity.
Hellmann J, Sansbury BE, Holden CR, Tang Y, Wong B, Wysoczynski M, Rodriguez J, Bhatnagar A, Hill BG, Spite M.
Diabetes. 2016 Aug; 65(8):2268-81.
IL-11 Induces Th17 Cell Responses in Patients with Early Relapsing-Remitting Multiple Sclerosis.
Zhang X, Tao Y, Chopra M, Dujmovic-Basuroski I, Jin J, Tang Y, Drulovic J, Markovic-Plese S.
J Immunol. 2015 Jun 1; 194(11):5139-49.
Atf3 Negatively Regulates Ptgs2/Cox2 Expression During Acute Inflammation.
Hellmann J, Tang Y, Zhang MJ, Hai T, Bhatnagar A, Srivastava S, Spite M.
Prostaglandins Other Lipid Mediat. 2015 Jan-Mar; 116-117:49-56.
The Role of Endogenous IFN-Β in the Regulation of Th17 Responses in Patients with Relapsing-Remitting Multiple Sclerosis.
Tao Y, Zhang X, Chopra M, Kim MJ, Buch KR, Kong D, Jin J, Tang Y, Zhu H, Jewells V, Markovic-Plese S.
J Immunol. 2014 Jun 15; 192(12):5610-7.
Increased Saturated Fatty Acids in Obesity Alter Resolution of Inflammation in Part by Stimulating Prostaglandin Production.
Hellmann J, Zhang MJ, Tang Y, Rane M, Bhatnagar A, Spite M.
J Immunol. 2013 Aug 1; 191(3):1383-92.
Proresolution Therapy for the Treatment of Delayed Healing of Diabetic Wounds.
Tang Y, Zhang MJ, Hellmann J, Kosuri M, Bhatnagar A, Spite M.
Diabetes. 2013 Feb; 62(2):618-27.
Chronic Alcohol Exposure Disturbs Lipid Homeostasis At The Adipose Tissue-Liver Axis In Mice: Analysis Of Triacylglycerols Using High-Resolution Mass Spectrometry In Combination With In Vivo Metabolite Deuterium Labeling.
Wei X, Shi X, Zhong W, Zhao Y, Tang Y, Sun W, Yin X, Bogdanov B, Kim S, McClain C, Zhou Z, Zhang X.
PLoS One. 2013; 8(2):e55382.
Overexpression of Endothelial Nitric Oxide Synthase Prevents Diet-Induced Obesity and Regulates Adipocyte Phenotype.
Sansbury BE, Cummins TD, Tang Y, Hellmann J, Holden CR, Harbeson MA, Chen Y, Patel RP, Spite MR, Bhatnagar A, Hill BG.
Circulation Research. 2012 Oct 12; 111(9):1176-89.
Proresolving Lipid Mediators and Diabetic Wound Healing.
Hellmann J, Tang Y, Spite M.
Curr Opin Endocrinol Diabetes Obes. 2012 Apr; 19(2):104-8.
Chronic Alcohol Exposure Stimulates Adipose Tissue Lipolysis in Mice: Role of Reverse Triglyceride Transport in the Pathogenesis of Alcoholic Steatosis.
Zhong W, Zhao Y, Tang Y, Wei X, Shi X, Sun W, Sun X, Yin X, Sun X, Kim S, McClain CJ, Zhang X, Zhou Z.
Am J Pathol. 2012 Mar; 180(3):998-1007.
Activation of Peroxisome Proliferator-Activated Receptor-Gamma by Rosiglitazone Improves Lipid Homeostasis at the Adipose Tissue-Liver Axis in Ethanol-Fed Mice.
Sun X, Tang Y, Tan X, Li Q, Zhong W, Sun X, Jia W, McClain CJ, Zhou Z.
Am J Physiol Gastrointest Liver Physiol. 2012 Mar 1; 302(5):G548-57.
Metsign: A Computational Platform for High-Resolution Mass Spectrometry-Based Metabolomics.
Wei X, Sun W, Shi X, Koo I, Wang B, Zhang J, Yin X, Tang Y, Bogdanov B, Kim S, Zhou Z, McClain C, Zhang X.
Anal Chem. 2011 Oct 15; 83(20):7668-75.
Deficiency of the Leukotriene B4 Receptor, BLT-1, Protects Against Systemic Insulin Resistance in Diet-Induced Obesity.
Spite M, Hellmann J, Tang Y, Mathis SP, Kosuri M, Bhatnagar A, Jala VR, Haribabu B.
J Immunol. 2011 Aug 15; 187(4): 1942-9.
Resolvin D1 Decreases Adipose Tissue Macrophage Accumulation and Improves Insulin Sensitivity in Obese-Diabetic Mice.
Hellmann J, Tang Y, Kosuri M, Bhatnagar A, Spite M.
FASEB J. 2011 Jul; 25(7): 2399-407.
Zinc Supplementation Partially Prevents Renal Pathological Changes in Diabetic Rats.
Tang Y, Yang Q, Lu J, Zhang X, Suen D, Tan Y, Jin L, Xiao J, Xie R, Rane M, Li X, Cai L.
J Nutr Biochem. 2010 Mar; 21(3):237-46.
IFN-Beta1a Inhibits the Secretion of Th17-Polarizing Cytokines in Human Dendritic Cells Via TLR7 Up-Regulation.
Zhang X, Jin J, Tang Y, Speer D, Sujkowska D, Markovic-Plese S.
J Immunol. 2009 Mar 15; 182(6):3928-36.
Degenerate TCR Recognition and Dual DR2 Restriction of Autoreactive T-Cells: Implications for the Initiation of the Autoimmune Response in Multiple Sclerosis.
Zhang X, Tang Y, Sujkowska D, Wang J, Ramgolam V, Sospedra M, Adams J, Martin R, Pinilla C, and Markovic-Plese S.
Eur J Immunol. 2008 May; 38(5):1297-309.
Effect of Folic Acid on Prenatal Alcohol-Induced Modification of Brain Proteome in Mice.
Xu Y, Tang Y, Li Y.
Br J Nutr. 2008 Mar; 99(3):455-61.
Immunomodulatory Effects of 3-Hydroxy-3-Methylglutaryl Coenzyme-A Reductase Inhibitors, Potential Therapy for Relapsing Remitting Multiple Sclerosis.
Peng X, Jin J, Giri S, Montes M, Sujkowski D, Tang Y, Smrtka J, Vollmer T, Singh I, Markovic-Plese S.
J Neuroimmunol. 2006 Sep; 178(1-2): 130-139.
The Maternal Combined Supplementation of Folic Acid and Vitamin B12 Suppresses Ethanol-Induced Developmental Toxicity in Mouse Fetuses.
Xu Y, Li Y, Tang Y, Wang J, Shen X, Long Z, Zheng X.
Reprod Toxicol. 2006 Jul; 22(1): 56-61.
Contact information for all lab members:
Hyun-Ki Kang, MS
Seonggi Min, Ph.D.
Dong-Jin Yang, MS
Jinghai Yi, Ph.D.
Inhalation Mechanical Engineer
- Contact Information
- Yunan Tang
- (870) 543-7391
ExpertiseApproachDomainTechnology & DisciplineToxicology