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  1. Science & Research (NCTR)

Huixiao Hong Ph.D.

Research Chemist — Division of Bioinformatics and Biostatistics

Huixiao Hong
Huixiao Hong, Ph.D.

(870) 543-7391
NCTRResearch@fda.hhs.gov  

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About  |  Publications  |  Lab Members


Background

Huixiao Hong received his Ph.D. from Nanjing University in China in 1990 and conducted post-doctoral research at Maxwell Institute in Leeds University in England in 1990-1992. He was an Associate Professor and the Director of Laboratory of Computational Chemistry at Nanjing University in China in 1992-1995. He was a visiting scientist at National Cancer Institute (NCI) at National Institutes of Health (NIH) in 1995-1998. Dr. Hong held a Research Scientist position at Sumitomo Chemical Company in Japan in 1998-2000. He was a senior computational scientist in ROW Science in 2000-2002. He was the Manager of Bioinformatics Division at Z-Tech, an ICFI company, at NCTR in 2002-2007. He was a Research Chemist in 2007-2018, and is now a Supervisory Research Chemist and the Chief of the Bioinformatics Branch in the Division of Bioinformatics and Biostatistics. He has more than 180 publications and has received many awards during his career.

Research Interests

Dr. Hong has a spectrum of research interests, including chemoinformatics, computational chemistry, next-generation sequencing data analysis, genome-wide association studies, proteomics, and systems biology. His current research goals are to assess repeatability of whole-genome sequencing technology, as well as to evaluate reproducibility of germline variants called from whole-genome sequencing data. Additionally, he is looking to construct an androgenic-activity database to enhance the endocrine disruptor knowledge base. Dr. Hong is also working to develop predictive models for assistance of safety evaluation of FDA-regulated products.

National and International Groups

Middle South Computational Biology & Bioinformatics
Board of Directors
Member
2016 – Present

OpenTox
Steering Committee
Member
2018 – Present

OpenTox USA 2018 (July 11-12, Durham, NC)
Conference Chair
 

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Select Publications

Publication titles are linked to text abstracts on PubMed.

Structural Changes Due to Antagonist Binding in Ligand Binding Pocket of Androgen Receptor Elucidated Through Molecular Dynamics Simulations.
Sakkiah S., Kusko R., Pan B., Guo W., Ge W., Tong W., and Hong H.
Front Pharmacol. 2018 May 15, 9:492. doi: 10.3389/fphar.2018.00492.
 

In silico Pharmacoepidemiologic Evaluation of Drug-Induced Cardiovascular Complications Using Combined Classifiers.
Cai C., Fang J., Guo P., Wang Q., Hong H., Moslehi J., and Cheng F.
J Chem Inf Model. 2018 May 29, 58(5):943-956. doi: 10.1021/acs.jcim.7b00641.
 

Competitive Docking Model for Prediction of the Human Nicotinic Acetylcholine Receptor α7 Binding of Tobacco Constituents.
Ng H.W., Leggett C., Sakkiah S., Pan B., Ye H., Wu L., Selvaraj C., Tong W., and Hong H.
Oncotarget. 2018 Feb 8, 9(24):16899-16916. doi: 10.18632/oncotarget.24458.
 

Deep Learning Architectures for Multi-Label Classification of Intelligent Health Risk Prediction.
Maxwell A., Li R., Yang B., Weng H., Ou A., Hong H., Zhou Z., Gong P., and Zhang C.
BMC Bioinformatics. 2017 Dec 28, 18(Suppl 14):523. doi: 10.1186/s12859-017-1898-z. 

 
Endocrine Disrupting Chemicals Mediated Through Binding Androgen Receptor are Associated with Diabetes mellitus.
Sakkiah S., Wang T., Zou W., Wang Y., Pan B., Tong W., and Hong H.
Int J Environ Res Public Health. 2017 Dec 23, 15(1). pii: E25. doi: 10.3390/ijerph15010025.
 

Development of Decision Forest Models for Prediction of Drug-Induced Liver Injury in Humans Using a Large Set of FDA-Approved Drugs.
Hong H., Thakkar S., Chen M., and Tong W.
Sci Rep. 2017 Dec 11, 7(1):17311. doi: 10.1038/s41598-017-17701-7. 
 

Development of Estrogen Receptor Beta Binding Prediction Model Using Large Sets of Chemicals.
Sakkiah S., Selvaraj C., Gong P., Zhang C., Tong W., and Hong H.
Oncotarget. 2017 Oct 10, 8(54):92989-93000. doi: 10.18632/oncotarget.21723. 
 

Multiple MicroRNAs Function as Self-Protective Modules in Acetaminophen-Induced Hepatotoxicity in Humans.
Yu D., Wu L., Gill P., Tolleson W.H., Chen S., Sun J., Knox B., Jin Y., Xiao W., Hong H., Wang Y., Ren Z., Guo L., Mei N., Guo Y., Yang X., Shi L., Chen Y., Zeng L., Dreval K., Tryndyak V., Pogribny I., Fang H., Shi T., McCullough S., Bhattacharyya S., Schnackenberg L., Mattes W., Beger R.D., James L., Tong W., and Ning B.
Arch Toxicol. 2018 Feb, 92(2):845-858. doi: 10.1007/s00204-017-2090-y. 
 

Direct Comparison of Performance of Single Nucleotide Variant Calling in Human Genome with Alignment-Based and Assembly-Based Approaches.
Wu L., Yavas G., Hong H., Tong W., and Xiao W.
Sci Rep. 2017 Sep 8, 7(1):10963. doi: 10.1038/s41598-017-10826-9.
 

Molecular Dynamics Simulations and Applications in Computational Toxicology and Nanotoxicology.
Selvaraj C., Sakkiah S., Tong W., and Hong H.
Food Chem Toxicol. 2018 Feb, 112:495-506. doi: 10.1016/j.fct.2017.08.028. 
 

Mechanistic Roles of MicroRNAs in Hepatocarcinogenesis: A Study of Thioacetamide with Multiple Doses and Time-Points of Rats.
Dweep H., Morikawa Y., Gong B., Yan J., Liu Z., Chen T., Bisgin H., Zou W., Hong H., Shi T., Gong P., Castro C., Uehara T., Wang Y., and Tong W.
Sci Rep. 2017 Jun 8, 7(1):3054. doi: 10.1038/s41598-017-02798-7.
 

 
 

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Lab Members

Contact information for all lab members:
(870) 543-7391
NCTRResearch@fda.hhs.gov 

Suguna Devi Sakkiah, Ph.D.
Postdoctoral Fellow

Bohu Pan, Ph.D.
Postdoctoral Fellow

Wenjing Guo, Ph.D
Postdoctoral Fellow

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Contact Information
Huixiao Hong
(870) 543-7391
Expertise
Expertise
Approach
Domain
Technology & Discipline
Toxicology