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  1. Science & Research (NCTR)

Jie Liu Ph.D.
Leadership Role

Staff Fellow — Division of Bioinformatics and Biostatistics

Portrait of Jie Liu, Ph.D.


Jie Liu, Ph.D.
(870) 543-7121

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About  |  Publications


Dr. Jie Liu received a master’s degree in immunology from Peking Union Medical College, China and a Ph.D. in bioinformatics from the University of Arkansas at Little Rock. She then conducted postdoctoral research at FDA’s Center for Food Safety and Applied Nutrition and worked as a research scientist at Altamira, LLC. She joined FDA’s National Center for Toxicological Research (NCTR) in 2020 as a staff fellow in the Division of Bioinformatics and Biostatistics.

Research Interests

Dr. Liu’s specialized research focuses on the computational toxicology for risk evaluation and safety assessment. She has developed toxicity databases and computational models for liver and other organ toxicity prediction by integrating data from multiple sources. Currently, Dr. Liu is working on the development of computational models and toxicity databases for endocrine toxicity prediction.

Professional Societies/National and International Groups 

Society of Toxicology
2015 – 2016

Selected Publications

Nanomaterial Databases: Data Sources for Promoting Design and Risk Assessment of Nanomaterials.
Ji Z., Guo W., Sakkiah S., Liu J., Patterson T.A., and Hong, H.
Nanomaterials (Basel). 2021, 11(6):1599; doi: 10.3390/nano11061599.

BPA Replacement Compounds: Current Status and Perspectives.
Ji Z., Liu J., Sakkiah S., Guo W., and Hong H.
ACS Sustainable Chem. Eng. 2021, 9, 6:2433-2446; doi: 10.1021/acssuschemeng.0c09276.

Identification of Epidemiological Traits by Analysis of SARS-CoV-2 Sequences.
Pan B., Ji Z., Sakkiah S., Guo W., Liu J., Patterson T.A., and Hong H.
Viruses. 2021, 13(5):764; doi: 10.3390/v13050764.

Elucidation of Agonist and Antagonist Dynamic Binding Patterns in ER-α by Integration of Molecular Docking, Molecular Dynamics Simulations and Quantum Mechanical Calculations.
Sakkiah S., Selvaraj C., Guo W., Liu J., Ge W., Patterson T.A., and Hong H.
Int J Mol Sci. 2021, 22(17):9371; doi: 10.3390/ijms22179371.

Utility of Generational Developmental and Reproductive Toxicity and Juvenile Animal Study Protocols for the Infant Safety Assessment of Food Contact Materials.
Neal-Kluever A., Nartey Q., Aungst J., Basso F., Davis-Bruno K., Elayan I., Liu J., Ravindran A., and Wu Y.
Toxicol Res and Appl. 2018, 2:1-21; doi: 10.1177/2397847318806043.

Predicting Organ Toxicity Using In Vitro Bioactivity Data and Chemical Structure.
Liu J., Patlewicz G., Williams A.J., Thomas R.S., and Shah I.
Chem Res Toxicol. 2017, 30(11):2046-2059; doi: 10.1021/acs.chemrestox.7b00084.

Systematically Evaluating Read-Across Prediction and Performance Using a Local Validity Approach Characterized by Chemical Structure and Bioactivity Information.
Shah I., Liu J., Judson R.S., Thomas R.S., and Patlewicz G.
Regul Toxicol Pharmacol. 2016, 79:12-24; doi: 10.1016/j.yrtph.2016.05.008.

Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure.
Shah I., Setzer R.W., Jack J., Houck K.A., Judson R.S., Knudsen T.B., Liu J., Martin M.T., Reif D.M., Richard A.M., Thomas R.S., Crofton K.M., Dix D.J., and Kavlock R.J.
Environ Health Perspect. 2016, 124(7):910-919; doi: 10.1289/ehp.1409029.

Predicting Hepatotoxicity Using ToxCast In Vitro Bioactivity and Chemical Structure.
Liu J., Mansouri K., Judson R.S., Martin M.T., Hong H., Chen M., Xu X., Thomas R.S., and Shah I.
Chem Res Toxicol. 2015, 28(4):738-751; doi: 10.1021/tx500501h.

Contact Information
Jie Liu
(870) 543-7121
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