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  1. Getting Started with ESG NextGen

User Guides

USP User Guide

ESG NextGen’s Unified Submission Portal (USP) is a web-based interface which serves as the primary platform for preparing, submitting, and managing electronic regulatory submissions to the FDA. The USP replaces legacy ESG WebTrader. 

To review the USP workflows and processes, please download and read the ESG NextGen USP User Guide below. 

USP User Guide

AS2 User Guide

ESG NextGen will continue to support legacy ESG AS2 account users. To understand updates needed to submit to ESG NextGen via AS2, please download and read the ESG NextGen AS2 User Guide below. 

 AS2 User Guide

 ESGNG AS2 Setup Instructions

 Creating tar Files and Compressing Files for Submission

 Digital Certificates

API User Guide

ESG NextGen provides new web service Application Programming Interfaces (APIs) to submit files, check submission status, and retrieve acknowledgements. Companies can integrate these APIs with their systems to achieve submission and other business workflow automation. To understand the ESG NextGen APIs and workflows, please download and read the ESG NextGen API User Guide below. 

 API User Guide 

 For a technical explanation of the ESG NextGen APIs, please download and review the ESG NextGen API Specification below. 

 API Specification

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