The following home preparation instructions for doxycycline, prepared by the CDC, are not to be used except in the case of a declared public health emergency. The scientific research below provided data to support the development of home preparation instructions for doxycycline:
- Stability, dose uniformity and palatability of doxycycline were studied. (Sadrieh N, Brower J, Yu L et al. (2005) Stability, dose uniformity, and palatability of three counterterrorism drugs – human subject and electronic tongue studies. Pharmaceutical Research 22:1747-1756.). The following links contain information on the palatability, stability, and dose uniformity of doxycycline.
- Crushing the pills is difficult. Dissolution studies demonstrated that the pills could be softened for 5 minutes in water prior to crushing, thereby making the crushing easier (unpublished information).
These emergency home preparation instructions for doxycycline have been prepared by CDC for use only during a public health emergency, and should only be distributed and used if instructed to do so by a public health official during such an emergency.