Doxycycline and penicillin G procaine are antibiotics used to treat bacterial infections in many different parts of the body. Antibiotics do not work for viral infections (for example, the common cold). Doxycycline and penicillin G procaine have been approved for all forms of anthrax. (inhalational, gastrointestinal, and cutaneous). On November 2, 2001, FDA published a Federal Register notice (66 FR 55679) clarifying that these drugs are approved for inhalational anthrax (post-exposure). Use of doxycycline in children under 8 years presents special concerns because of possible tooth discoloration. Long-term use of intravenous doxycycline or penicillin G procaine presents safety concerns, and patients should be switched, when appropriate, to oral antibiotics to complete a 60 day course of therapy for inhalational anthrax (post-exposure). For more information, see Doxycycline Use by Pregnant and Lactating Women.
List of Published Literature Relied on in Issuing the Federal Register Notice on Doxycycline and Penicillin G Procaine Administration for Inhalational Anthrax (Post-Exposure)
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