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  1. National Center for Toxicological Research

Tariq Fahmi F M.D. Ph.D.

Tariq Fahmi

Staff Fellow — Office of Scientific Coordination

Dr. Tariq Fahmi

Tariq Fahmi, M.D., Ph.D.
(870) 543-7391
NCTRResearch@fda.hhs.gov  

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About  |  Publications


Background

Dr. Tariq Fahmi received his medical degree from Al-Mustansiriya University, Baghdad, Iraq in 1996. He went on to earn a Master of Science degree in pathology in 2002 from the medical college of Al-Nahrain University, Baghdad, Iraq; and a Ph.D. in oncology in 2010 from the Institute of Oncology, Hacettepe University, in Ankara, Turkey. Dr. Fahmi was a faculty member in the Department of Pathology at Al-Mustansiriya University from 1998-2010 while pursuing his master’s degree and Ph.D.  Dr. Fahmi received a fellowship from the University of Arkansas for Medical Sciences (UAMS) upon completion of his Ph.D. He joined FDA’s NCTR/Office of Regulatory Affairs Nanotechnology Core Facility (Nanocore) in 2015, where he conducted scientific publication and monograph reviews with a team of scientists to provide briefs for regulatory decisions by the Center for Drug Evaluation and Research (CDER). Dr. Fahmi has received FDA’s NCTR Scientific Achievement Award for “Excellence in Review Science” for his work on the monograph reviews.

Research Interests 

Dr. Fahmi is primarily interested in:

  • the causes of disease, including pathogenesis, diagnosis, and the identification of potential therapeutics
  • immunology, especially as it relates to immunotoxicology of nanomaterials
  • hstopathology
  • mitigating tissue injury using several synthetic chemical inhibitors, including nanoparticle-based delivery systems
  • investigating the mechanisms of cell death using different models
  • the role of serotonin transporters in protecting placental cells against cell death
  • identifying how nanotoxicology influences and impacts human immunotoxicology

Dr. Fahmi has extended his research experience working with cancer models by investigating the effects of altered expression of human UDP-Glucuronosyltransferase (UGT) genes in breast and pancreatic cancers which identified the role of UGTs as lipid-controllers in cellular homeostasis and helped identify them as possible targets for future clinical therapeutic development.

Described below are Dr. Fahmi’s current research efforts at NCTR:

  • He is studying the immunotoxicology of nanomaterial towards biocompatibility assessment and how nanomaterial structure and composition influences their safety and efficacy in FDA-regulated products. To this end, Dr. Fahmi is conducting research at the Nanocore on the effects of nanoparticles on the human immune system which is also leading to collaborative consensus-standards development with other stakeholders, through standards development organizations, such as the American Society for Testing and Materials.
  • He is identifying how nanotoxicology influences and impacts human immunotoxicology. This focus led him to investigate the possible mechanisms of nanoparticle-induced cell death following exposure to nanomaterials. He has conducted several research projects that involved 1) the delivery and measurement of the toxicity of different nanomaterials and 2) the development of methods for the evaluation of nanoparticles toxicity. Dr. Fahmi has also investigated the role of endonucleases in the mechanism of graphene and carbon nanotubes cytotoxicity. He helped to develop 1) a photoacoustic in vitro flow cytometry method for the evaluation of nanomaterial toxicity and 2) multi-functional nanomaterials for targeting circulating cancer cells.

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Selected Publications

Serotonin Transporter Protects the Placental Cells Against Apoptosis in Caspase 3-Independent Pathway.
Hadden C., Fahmi T., Cooper A., Savenka A., Lupashin V., Roberts D., Maroteaux L., Hauguel-de Mouzon S. and Kilic F.
J Cell Physiol. 2017 Dec, 232(12):3520-3529. doi: 10.1002/jcp.25812. (* Represents equal contribution (co-first authorship))
 

Mechanism of Graphene-Induced Cytotoxicity: Role of Endonucleases.
Fahmi T., Branch D., Nima Z., Jang D., Savenka A., Biris A. and Basnakian A.
J Appl Toxicol. 2017 Nov, 37(11):1325-1332. doi: 10.1002/jat.3462.
 

Photoacoustic In Vitro Flow Cytometry for Nanomaterial Research.
Nedosekin D., Fahmi T., Nima Z., Nolan J., Cai C., Sarimollaoglu M., Dervishi E., Basnakian A., Biris A. and Zharov V.
Photoacoustics. 2017 Mar 27, 6:16-25. doi: 10.1016/j.pacs.2017.03.002.
 

Mutant Profilin1 Transgenic Mice Recapitulate Cardinal Features of Motor Neuron Disease.
Fil D., DeLoach A., Yadav S., Alkam D., MacNicol M., Singh A., Compadre C., Goellner J., O'Brien C., Fahmi T., Basnakian A., Calingasan N., Klessner J., Flint Beal M., Peters O., Metterville J., Brown R., Ling K., Rigo F., Ozdinler P. and Kiaei M.
Hum Mol Genet. 2017 Feb 15, 26(4):686-701. doi: 10.1093/hmg/ddw429
 

Human UDP-Glucuronosyltransferases: Effects of Altered Expression in Breast and Pancreatic Cancer Cell Lines.
Dates C., Fahmi T., Pyrek S., Yao-Borengasser A., Borowa-Mazgaj B., Bratton S., Kadlubar S., Mackenzie P., Haun R., Radominska-Pandya A.
Cancer Biol Ther. 2015, 16(5):714-23. doi: 10.1080/15384047.2015.1026480. (* Represents equal contribution (co-first authorship))
 

Impact of Hydroxychloroquine on Atherosclerosis and Vascular Stiffness in the Presence of Chronic Kidney Disease.
Shukla A., Bose C., Karaduta O., Apostolov E., Kaushal G., Fahmi T., Segal M., and Shah S.
PLoS One. 2015 Sep 28, 10(9): e0139226. doi: 10.1371/journal.pone.0139226.
 

Regulation of Apoptotic Endonucleases by EndoG.
Zhdanov D., Fahmi T., Wang X., Apostolov E., Sokolov N., Javadov S. and Basnakian A.
DNA Cell Biol. 2015 May, 34(5):316-26. doi: 10.1089/dna.2014.2772.
 

Novel High-Throughput Deoxyribonuclease 1 Assay.
Jang D., Penthala N., Apostolov E., Wang X., Fahmi T., Crooks P. and Basnakian A.
J Biomol Screen. 2015 Feb, 20(2):202-11. doi: 10.1177/1087057114555828.
 

Single-Walled Carbon Nanotube and Graphene Nanodelivery of Gambogic Acid Increases its Cytotoxicity in Breast and Pancreatic Cancer Cells.
Saeed L., Mahmood M., Pyrek S., Fahmi T., Xu Y., Mustafa T., Nima Z., Bratton S., Casciano D., Dervishi E., Radominska-Pandya A. and Biris A.
J Appl Toxicol. 2014 Nov, 34(11):1188-99. doi: 10.1002/jat.3018.
 

Circulating Tumor Cell Identification by Functionalized Silver-Gold Nanorods with Multicolor, Super-Enhanced SERS and Photothermal Resonances.
Nima Z., Mahmood M., Xu Y., Mustafa T., Watanabe F., Nedosekin D., Juratli M., Fahmi T., Galanzha E., Nolan J., Basnakian A., Zharov V. and Biris A.
Sci Rep. 2014 May 9, 4:4752. doi: 10.1038/srep04752.
 

Immune Compartmentalization of T Cell Subsets in Chemically-Induced Breast Cancer.
Fahmi T., Esendagli G., Yilmaz G., Kansu E. and Guc D.
Scand J Immunol. 2010 Oct, 72(4):339-48. doi: 10.1111/j.1365-3083.2010.02447

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Contact Information
Tariq Fahmi
(870) 543-7391
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