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  1. Science & Research (NCTR)

Tao Chen Ph.D.

Research Toxicologist — Genetic and Molecular Toxicology

Tao Chen
Tao Chen, Ph.D., DABT

(870) 543-7391
NCTRResearch@fda.hhs.gov  

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About  |  Publications  |  Lab Members


Background

 Dr. Chen received his Ph.D. degree in toxicology from the University of Arkansas for Medical Sciences in 1997. After graduation, he worked as a postdoctoral scientist at Duke University until 2000. Dr. Chen was an FDA staff fellow in the Division of Genetic and Molecular Toxicology from 2000 to 2002 and has been a research toxicologist in 2003. Dr. Chen has been a Diplomate of the American Board of Toxicology since 1999.

Research Interests

Dr. Chen leads a team that conducts research to develop and validate genotoxic methods and to better understand the genotoxicity of FDA-related products. Dr. Chen’s early research mainly addressed the validation of rodent transgenic-mutation systems and the development of different methods for the molecular characterization of chemical-induced mutations. He has investigated mutagenicity and fundamental mechanisms of mutagens associated with FDA regulations, such as tamoxifen, retinyl palmitate, aristolochic acid, acrylamide, and other drug impurities using different genotoxicity endpoints. He has recently focused his research on the evaluation of genotoxicity assays for assessing nanomaterials. He also looks to the development of new microRNA assays to supplement current genotoxicity battery. Finally, Dr. Chen is interested in the assessment of chemical-induced somatic and germline mutations using next-generation sequencing methods.

Professional Societies/National and International Groups

Environmental Mutagen Society
Member
1995 – Present

ILSI HESI Genetic Toxicology Technical Committee
Member
2012 – Present

International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) Genomics Committee
Member
2005 – Present 

MidSouth Computational Biology and Bioinformatics Society
Member
2006 – Present

Sequencing Quality Control Consortium
Member
2013 – Present

Society of Toxicology
Member
1997 – Present

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Select Publications

Publication titles are linked to text abstracts on PubMed.

Genotoxicity and Gene Expression Analyses of Liver and Lung Tissues of Mice Treated with Titanium Dioxide Nanoparticles.
Li Y, Yan J, Ding W, Chen Y, Pack M, Chen T.
Mutagenesis. 2017 Jan; 32 (1): 33-46.
 

Factors Affecting the In Vitro Micronucleus Assay for Evaluation of Nanomaterials.
Li Y, Doak S. H, Yan J, Chen H, Zhou M, Mittelstaedt A, Chen Y, Li C, Chen T.
Mutagenesis. 2017 Jan; 32 (1): 151-159.
 

Absolute Measurement of Cardiac Injury-Induced microRNAs in Biofluids Across Multiple Test Sites.
Thompson L, Boitier E, Chen T, Couttet P, Ellinger-Ziegelbauer H, Goetschy M, Guillemain G, Kanki M, Kelsall J, Mariet C, de La Moureyre-Spire C, Mouritzen P, Nassirpour R, O'Lone R, Pine S, Rosenzweig A, Sharapova T, Smith A, Uchiyama H, Yan J, Yuen S, Wolfinger R.
Toxicol Sci. 2016 Nov; 154 (1): 115-125.
 

Size- and Coating-Dependent Cytotoxicity and Genotoxicity of Silver Nanoparticles Evaluated Using In Vitro Standard Assays.
Guo X, Li Y, Yan J, Ingle T, Jones Y, Mei N, Boudreau D, Cunningham K, Abbas M, Paredes M, Zhou T, Moore M, Howard C, Chen T.
Nanotoxicology. 2016 Aug 10; 10 (9): 1373-84.
 

Differential Genotoxicity Mechanisms of Silver Nanoparticles and Silver Ions.
Li Y, Qin T, Ingle T, Yan J, He W, Yin J, Chen T.
Arch Toxicol. 2016 May 14; 10 (9): 1373–1384.
 

Decrease of 5-Hydroxymethylcytosine in Rat Liver with Subchronic Exposure to Genotoxic Carcinogens Riddelliine and Aristolochic Acid.
Lian G, Xu S, Guo W, Yan J, Frank M. Y, Liu R, Liu C, Chen Y, Murphy F, Chen T.
Mol Carcinog. 2015 Nov; 54 (11): 1503-7.
 

Integrated MicroRNA, MRNA, and Protein Expression Profiling Reveals MicroRNA Regulatory Networks in Rat Kidney Treated with a Carcinogenic Dose of Aristolochic Acid.
Li Z, Qin, T, Wang K, Hackenberg M, Yan J, Gao Y, Yu L. R, Shi L, Su Z, Chen T.
BMC Genomics. 2015 May 8; 16 365.
 

Causes of Genome Instability: The Effect of Low Dose Chemical Exposures in Modern Society.
Langie S. A, Koppen G, Desaulniers D, Al-Mulla F, Al-Temaimi R, Amedei A, Azqueta A, Bisson H, Brown D, Brunborg G, Charles K, Chen T.
Carcinogenesis. 2015 Jan; 36 Suppl 1 S61-88.
 

Assessing the Carcinogenic Potential of Low-Dose Exposures to Chemical Mixtures in the Environment: The Challenge Ahead.
Goodson H, Lowe L, Carpenter O, Gilbertson M, Manaf Ali A, Lopez de Cerain Salsamendi A, Lasfar A, Carnero A, Azqueta A, Amedei A, Charles K, Chen T.
Carcinogenesis. 2015 Jan; 36 Suppl 1 S254-96.
 

A Comprehensive Assessment of RNA-seq Accuracy, Reproducibility and Information Content by the Sequencing Quality Control Consortium.
SEQC/MAQC-III Consortium.
Nat Biotechnol. 2014 Aug 24; 32 (9): 903-14.
 

Tissue-Specific microRNA Responses in Rats Treated with Mutagenic and Carcinogenic Doses of Aristolochic Acid.
Meng F, Li, Z, Yan J, Manjanatha M, Shelton S, Yarborough S, Chen T.
Mutagenesis. 2014 Aug 8; 29 (5): 357-65.
 

Absence of Mature MicroRNAs Inactivates the Response of Gene Expression to Carcinogenesis Induced by N-Ethyl-N-Nitrosourea in Mouse Liver.
Luan Y, Qi X, Xu L, Ren J, Chen T.
J Appl Toxicol. 2014 Jan 30; 34 (12): 1409-17.
 

Cytotoxicity and Genotoxicity Assessment of Silver Nanoparticles in Mouse.
Li Y, Bhalli A, Ding W, Yan J, Pearce G, Sadiq R, Cunningham K, Jones Y, Monroe A, Howard C, Zhou T, Chen T.
Nanotoxicology. 2014 Aug; 8(Suppl 1): 36-45.
 

miR-34a Suppresses Mutagenesis by Inducing Apoptosis in Human Lymphoblastoid TK6 Cells.
Chen X, Zhang Y, Yan J, Sadiq R, Chen T.
Mutat Res. 2013 Dec 12; 758 (1-2): 35-40.
 

Genotoxicity of 2-Bromo-3'-Chloropropiophenone.
Meng F, Yan J, Li Y, Fu P, Fossom H, Sood K, Mans J, Chu I, Moore M, Chen T.
Toxicol Appl Pharmacol. 2013 July 15; 270 (2): 158-63.
 

Genotoxicity of TiO2 Anatase Nanoparticles in B6C3F1 Male Mice Evaluated Using Pig-A and Flow Cytometric Micronucleus Assays.
Sadiq R, Bhalli J. A, Yan J, Woodruff R. S, Pearce M. G, Li Y, Mustafa T, Watanabe F, Pack M, Biris A, Khan M, Chen T.
Mutat Res. 2012 Jun 14; 745 65-72.
 

Discovery of Novel MicroRNAs in Rat Kidney Using Next Generation Sequencing and Microarray Validation.
Meng F, Hackenber M, Li Z, Yan J, Chen T.
PLoS One. 2012 May 28; 7 (3): e34394.
 

Silver Nanoparticle-Induced Mutations and Oxidative Stress in Mouse Lymphoma Cells.
Mei N, Zhang Y, Chen Y, Guo X, Ding W, Ali F, Biris S, Rice P, Moore M, Chen T.
Environ Mol Mutagen. 2012 May 10; 53 (6): 409-19.
 

Expression Level of Mir-34a Rather Than P53 Gene Status Correlates with Mutability in Related Human Lymphoblast Cell Lines.
Chen X, Yan J, Chen T.
Mol Carcinog. 2012 Aug; 51 (8): 674-7.
 

MicroRNA Expression Profiles Distinguish the Carcinogenic Effects of Riddelliine in Rat Liver.
Chen T, Li Z, Yan J, Yang X, Salminen W.
Mutagenesis. 2012 Jan; 27 (1): 59-66.
 

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Lab Members

Contact information for all lab members:
(870) 543-7391
NCTRResearch@fda.hhs.gov

Hua Du, Ph.D.
Postdoctoral fellow

Bohu Pan, Ph.D.
Postdoctoral fellow

Jian Yan, M.S.
Chemist

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Contact Information
Tao Chen
(870) 543-7391
Expertise
Expertise
Approach
Domain
Technology & Discipline
Toxicology