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  1. Science & Research (NCTR)

Shuliang Liu Ph.D.
Leadership Role

Visiting Scientist — Division of Neurotoxicology

Shuliang Liu, Ph.D.

Shuliang Liu, Ph.D.
(870) 543-7121

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About  |  Publications 


Dr. Shuliang Liu graduated with a bachelor’s in clinical medicine (1993) from Capital Medical University, China. In 1999, he earned his master’s in medical imaging and nuclear medicine from the same university. Dr. Liu worked as a registered radiologist at Xuanwu Hospital in Beijing China for 5 years. In 2005, he resumed his graduate training at the University of Arkansas for Medical Sciences in Little Rock, AR and earned his Ph.D. in biological sciences in 2010. He was awarded a post-doctoral fellowship in the Division of Neurotoxicology at NCTR from 2010 to 2013. For many years, Dr. Liu has been actively involved in biomedical research and has been an author and co-author on approximately 30 peer-reviewed scientific articles and book chapters in neurotoxicology, molecular biology, and medical imaging.

Research Interests

Since beginning at NCTR, Dr. Shuliang Liu has been conducting research on the adverse effects of general anesthetic exposure on the developing central nervous system (CNS). He has employed both in vivo and in vitro models to study the neurotoxicity of commonly-used general anesthetics on the developing CNS. The principal aim of Dr. Liu’s research is to evaluate the reversal effects of selected chemicals on anesthetic-induced neural cell damage.

Professional Societies/National and International Groups

Society of Toxicology
2015 – Present

Selected Publications

Potential Mechanisms for Phencyclidine/Ketamine-Induced Brain Structural Alterations and Behavioral Consequences.
Wang C., Inselman A., Liu S., and Liu F.
Neurotoxicology. 2020, 76:213-219. doi: 10.1016/j.neuro.2019.12.005. Review.

Effects of Xenon-Based Anesthetic Exposure on the Expression Levels of Polysialic Acid Neural Cell Adhesion Molecule (PSA-NCAM) on Human Neural Stem Cell-Derived Neurons.
Liu F., Liu S., Patterson T.A., Fogle C., Hanig J.P., Slikker W. Jr., and Wang C.
Mol Neurobiol. 2020, 57(1):217-225. doi: 10.1007/s12035-019-01771-x.

Protective Effects of Xenon on Propofol-Induced Neurotoxicity in Human Neural Stem Cell-derived Models.
Liu F., Liu S., Patterson T.A., Fogle C., Hanig J.P., Wang C., and Slikker W. Jr. 
Mol Neurobiol. 2020, 57(1):200-207. doi: 10.1007/s12035-019-01769-5.

Disturbed Energy Metabolism Present in Neonatal Monkeys after Sevoflurane Exposure as Evidenced with Marked Serum Lipid Changes: A Potential Causal Factor Leading to and Biomarkers for Neurotoxicity.
Wang C., Liu F., Frisch-Daiello J.L., Martin S., Patterson T.A., Gu Q., Liu S., Paule M.G., Hanig J.P., Slikker W. Jr., Crawford P.A., Wang C., and Han X.
Anal Chim Acta. 2018, 1037:87-96. doi: 10.1016/j.aca.2017.11.052. 

MicroPET/CT Assessment of FDG Uptake in Brain after Long-term Methylphenidate Treatment in Nonhuman Primates.
Zhang X., Newport G.D., Callicott R., Liu S., Thompson J., Berridge M.S., Apana S.M., Slikker W. Jr., Wang C., and Paule M.G. 
Neurotoxicol Teratol. 2016, 56:68-74. doi: 10.1016/j.ntt.2016.

In Vivo Monitoring of Sevoflurane-induced Neuronal Injury in Neonatal Nonhuman Primates Using Small-Animal Positron Emission Tomography.
Zhang X., Liu S., Liu F., Newport G.D., Paule M.G., Callicott R., Thompson J., Patterson T.A., Apana S.M., Berridge M.S., Maisha M.P., Hanig J.P., Slikker W. Jr., and Wang C.
Anesthesiology. 2016, 125(1):133-46. doi: 10.1097/ALN.0000000000001154. 

Positron Emission Topography with [18F]-FLT Revealed Sevoflurane-Induced Inhibition of Neural Progenitor Cell Expansion In Vivo.
Liu S., Paule M.G., Zhang X., Newport G.D., Apana S.M., Berridge M.S., Patterson T.A., Maisha M.P., Slikker W. Jr., and Wang C.
Front Neurol. 2014, 5:234. doi: 10.3389/fneur.2014.00234.

Ketamine-Induced Neuronal Damage and Altered N-methyl-D-aspartate (NMDA) Receptor Function in Rat Primary Forebrain Culture.
Liu F., Patterson T.A., Sadovova N., Zhang X., Liu S., Zou X., Hanig J.P., Paule M.G., Slikker W. Jr., and Wang C.
Toxicol Sci. 2013, 131(2):548-57. doi: 10.1093/toxsci/kfs296.

Inhalation Anesthetic-Induced Neuronal Damage in the Developing Rhesus Monkey.
Zou X., Liu F., Zhang X., Patterson T.A., Callicott R., Liu S., Hanig J.P., Paule M.G., Slikker W. Jr., and Wang C.  
Neurotoxicol Teratol. 2011, 33(5):592-7. doi: 10.1016/j.ntt.2011.06.003.

Contact Information
Shuliang Liu
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