Serguei Liachenko M.D., Ph.D.
Director, Bio-Imaging Lab — Division of Neurotoxicology
Serguei Liachenko, M.D., Ph.D.
(870) 543-7121
NCTRResearch@fda.hhs.gov
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About | Publications | Lab Members
Background
Dr. Serguei Liachenko studied at the Russian State Medical University in Moscow from 1981-1988. He then worked at several institutions in Russian pharmaceutical and biotechnology business. In 1994, he obtained an M.D. and a Ph.D. degree in pharmacology from the Russian Research Center for Bioactive Compounds in Moscow. After relocating to the U.S. in 1995, he completed postdoctoral training at the University of Pittsburgh from 1995-2002. During this time, he received the National Research Service Award from the National Institutes of Health. In 2002, Dr. Liachenko joined the Bio-Imaging Center of Emphasis at Pfizer, Inc. In September 2009, he accepted the position of director of Bio-Imaging at FDA's National Center for Toxicological Research (NCTR).
Research Interests
Current research interests include:
- discovering and developing nonclinical imaging biomarkers of drug toxicity and efficacy using magnetic resonance imaging and spectroscopy.
- investigating glutamine cycle involvement in neurotoxicity, neurological disorders, and addictive substances abuse
- elucidating the mechanisms of toxicity using magnetic resonance.
- continuous improvement of imaging/spectroscopic methods in nonclinical applications.
Dr. Liachenko’s expertise includes:
- biology
- pharmacology
- animal research
- bio-imaging, magnetic resonance, imaging analysis
- algorithms development
- additive (3D printing) and subtractive (3D milling) rapid prototyping.
Dr. Liachenko’s research goals include the development of imaging/spectroscopy biomarkers of toxicity to the stage of formal qualification by FDA, development of MRI toolboxes for routine applications in drug safety research, and elucidation of biochemical pathways of drug addiction using minimally invasive imaging technologies.
Professional Societies/National and International Groups
Health and Environmental Sciences Institute
Member
2010 – Present
International Society for Magnetic Resonance in Medicine
Member
2002 – 2014
Society of Toxicology
Member
2010 – 2014
Selected Publications
In Vivo Mapping of Rat Brain Partial White Matter Content Using Hexachlorophene-Induced Neurotoxicity Model.
Liachenko S. and Sarkar S.
Brain Res. 2024, 1830:14881.
Performance of the Prospective T2 MRI Biomarker of Neurotoxicity in a Trimethyltin Model in Rats at 7 T.
Liachenko S., Ramu J., Paule M.G., and Hanig J.
Neurotoxicol Teratol. 2023, 100:107289.
The Effects of Long-Term Methylphenidate Administration and Withdrawal on Progressive Ratio Responding and T2 MRI in the Male Rhesus Monkey.
Liachenko S., Chelonis J., Paule M.G., Li M., Sadovova N., and Talpos J.C.
Neurotoxicol Teratol. 2022: 107119.
Optimization of Detection of Gadodiamide Brain Retention in Rats Using Quantitative T2 Mapping and Intraperitoneal Administration.
Liachenko S.M., Sadovova N.V., Tripp A., Ghorai S., Patri A.K., Hanig J.P., Cohen J.E., and Krefting I.
J Magn Reson Imaging. 2022, 56(5):1499-1504.
Emerging Technologies and Their Impact on Regulatory Science.
Anklam E., Bahl M.I., Ball R., Beger R.D., Cohen J., Fitzpatrick S., Girard P., Halamoda-Kenzaoui B., Hinton D., Hirose A., Hoeveler A., Honma M., Hugas M., Ishida S., Kass G.E., Kojima H., Krefting I., Liachenko S., Liu Y., Masters S., Marx U., McCarthy T., Mercer T., Patri A., Pelaez C., Pirmohamed M., Platz S., Ribeiro A.J., Rodricks J.V., Rusyn I., Salek R.M., Schoonjans R., Silva P., Svendsen C.N., Sumner S., Sung K., Tagle D., Tong L., Tong W., Eijnden-van-Raaij J.V.D., Vary N., Wang T., Waterton J., Wang M., Wen H., Wishart D., Yuan Y., and Slikker W. Jr.
Exp Biol Med (Maywood). 2022, 247(1):1-75.
MicroCT Imaging of Heart Valve Tissue in Fluid.
Stephens S.E., Bean M., Surber H., Ingels N.B., Jensen H.K., Liachenko S., Wenk J.F., and Jensen M.O.
Exp Mech. 2021, 61(1):253-261.
Global Neurotoxicity: Quantitative Analysis of Rat Brain Toxicity Following Exposure to Trimethyltin.
Srivastava A., Liachenko S., Sarkar S., Paule M., Sadovova N., and Hanig J.P.
Int J Toxicol. 2021, 40(4):367-379.
Quantitative Neurotoxicology: An Assessment of the Neurotoxic Profile of Kainic Acid in Sprague Dawley Rats.
Srivastava A., Liachenko S., Sarkar S., Paule M., Negi G., Pandey J.P., and Hanig J.P.
Int J Toxicol. 2020, 39(4):294-306.
Sex Differences in the Effect of Acute Administration of Nicotine on MRS-Measured Metabolic Profile of the Rat Brain.
Liachenko S. and Ramu J.
Neurosci Res. 2020, 157:51-57.
A Multi-Center Preclinical Study of Dadoxetate DCE-MRI in Rats as a Biomarker of Drug Induced Inhibition of Liver Transporter Function.
Karageorgis A., Lenhard S.C., Yerby B., Forsgren M.F., Liachenko S., Johansson E., Pilling M.A., Peterson R.A., Yang X., Williams D.P., Ungersma S.E., Morgan R.E., Brouwer K.L.R., Jucker B.M., and Hockings P.D.
PLoS One. 2018, 13(5):e0197213.
Comparison of Quantitative T2 and ADC Mapping in the Assessment of 3-nitropropionic Acid-Induced Neurotoxicity in Rats.
Liachenko S., Ramu J., Paule M.G., and Hanig J.
Neurotoxicology. 2018, 65:52-59.
Changes in the Metabolome and microRNA levels in Biological Fluids Might Represent Biomarkers of Neurotoxicity: A Trimethyltin Study.
Imam S.Z., He Z., Cuevas E., Rosas-Hernandez H., Lantz S.M., Sarkar S., Raymick J., Robinson B., Hanig J.P., Herr D., MacMillan D., Smith A., Liachenko S., Ferguson S., O'Callaghan J., Miller D., Somps C., Pardo I.D., Slikker W. Jr., B. Pierson J., Roberts R., Gong B., Tong W., Aschner M., J. Kallman M., Calligaro D., and Paule M.G.
Exp Biol Med (Maywood). 2018, 243(3):228-236.
The Pathophysiological Sequence of Glucocorticoid-Induced Osteonecrosis of the Femoral Head in Male Mice.
Weinstein R.S., Hogan E.A., Borrelli M.J., Liachenko S., O'Brien C.A., and Manolagas S.C.
Endocrinology. 2017, 158(11):3817-3831.
High Resolution Imaging of the Mitral Valve in the Natural State with 7 Tesla MRI.
Stephens S.E., Liachenko S., Ingels N.B., Wenk J.F., and Jensen M.O.
PLoS One. 2017, 12(8):e0184042.
Brain Endothelial Dysfunction Following Pyrithiamine Induced Thiamine Deficiency in the Rat.
Sarkar S., Liachenko S., Paule M.G., Bowyer J., and Hanig J.P.
Neurotoxicology. 2016, 57:298-309.
Magnetic Resonance Spectroscopic Analysis of Neurometabolite Changes in the Developing Rat Brain at 7 Tesla.
Ramu J., Konak T., and Liachenko S.
Brain Res. 2016, 1651: 114-20.
Longitudinal Diffusion Tensor Imaging of the Rat Brain after Hexachlorophene Exposure.
Ramu J., Konak T., Paule M.G., Hanig J.P., and Liachenko S.
Neurotoxicology. 2016, 56: 225-32.
Quantification and Reproducibility Assessment of the Regional Brain T2 Relaxation in Naïve Rats at 7T.
Liachenko S., and Ramu J.
J Magn Reson Imaging. 2016, doi: 10.1002/jmri.25378.
Translational Biomarkers of Neurotoxicity: A Health and Environmental Sciences Institute Perspective on the Way Forward.
Roberts R.A., Aschner M., Calligaro D., Guilarte T.R., Hanig J.P., Herr D.W., Hudzik T.J., Jeromin A., Kallman M.J., Liachenko S., Lynch J.J. 3rd, Miller D.B., Moser V.C., O'Callaghan J.P., Slikker W. Jr., and Paule M.G.
Toxicol Sci. 2015, 148(2): 332-40.
Iron Oxide Nanoparticles Induce Dopaminergic Damage: In vitro Pathways and In vivo Imaging Reveals Mechanism of Neuronal Damage.
Imam S.Z., Lantz-McPeak S.M., Cuevas E., Rosas-Hernandez H., Liachenko S., Zhang Y., Sarkar S., Ramu J., Robinson B.L., Jones Y., Gough B., Paule M.G., Ali S.F., and Binienda Z.K.
Mol Neurobiol. 2015, 52(2): 913-26.
Lab Members
Contact information for all division scientists:
(870) 543-7121
NCTRResearch@fda.hhs.gov
Natalya Sadovova, Ph.D.
Staff Fellow
- Contact Information
- Serguei Liachenko
- (870) 543-7121
- Expertise
-
ExpertiseApproachDomainTechnology & DisciplineToxicology