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  1. Science & Research (NCTR)

Qiang Gu Ph.D.

Biologist — Division of Neurotoxicology

Qiang Gu
Qiang Gu, Ph.D.

(870) 543-7391
NCTRResearch@fda.hhs.gov  

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About  |  Publications  |  Lab Members


Background

Dr. Qiang Gu studied biology/biophysics at Justus Liebig University in Giessen, Germany and received graduate training in the Department of Neurophysiology at Max Planck Institute for Brain Research in Frankfurt, Germany. After postdoctoral research at the University of British Columbia in Vancouver, Canada, he was appointed as assistant professor in the Department of Ophthalmology and as investigator in the Brain Research Center at University of British Columbia. He was an assistant professor in the Department of Anatomy and Neurobiology at Wake Forest University School of Medicine in Winston-Salem, North Carolina before joining the Center of Excellence for Proteomics at NCTR's Division of Systems Biology. In 2011, he was recruited to the Division of Neurotoxicology at NCTR.

Research Interests

Dr. Gu’s research focuses on molecular changes associated with neurotoxicity in animal and cell-culture models. This effort is aimed at identifying biomarkers for neurotoxicity assessments as well as understanding signal-transduction cascades following neurotoxic insults and ultimately, molecular mechanisms underlying neurotoxicity.

Professional Societies/National and International Groups

Society for Neuroscience
Member
1991 – Present

Society of Toxicology
Member
2013 – Present

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Selected Publications

Downregulation of 14-3-3 Proteins in a Kainic Acid-Induced Neurotoxicity Model.
Smani D., Sarkar S., Raymick J., Kanungo J., Paule M.G., and Gu Q.
Mol Neurobiol. 2018, 55(1): 122-129.

Decreased Mcl-1 Protein Level in the Striatum of a Parkinson’s Disease Animal Model.
Lu E., Sarkar S., Raymick J., Paule M.G., and Gu Q.
Brain Res. 2018, 1678: 432-439.

The NMDA Receptors: Physiology and Neurotoxicology in the Developing Brain.disclaimer icon
Gu Q. and Wang C.
Handbook of Developmental Neurotoxicology. 2018, 207-214.

Neural Cell Lines (Lineage).disclaimer icon
Gu Q.
Neural Cell Biology. 2016, 169-186.

In Vitro Detection of Cytotoxicity Using FluoroJade-C.
Gu Q., Lantz-McPeak S., Rosas-Hernandez H., Cuevas E., Ali S.F., Paule M.G., and Sarkar S.
Toxicol In Vitro. 2014, 28(4): 469-72.

Optimizing Scan Parameters for Antibody Microarray Experiments: Accelerating Robust Systems Diagnostics for Life Sciences.
Gu Q. and Sivanandam T.M.
OMICS. 2014, 18(6): 385-98.

Proteomics Quality and Standard: From a Regulatory Perspective.
Gu Q. and Yu L.R.
J Proteomics. 2014, 96: 353-9.

One-Step Labeling of Degenerative Neurons in Unfixed Brain Tissue Samples Using Fluoro-Jade C.
Gu Q., Schmued L.C., Sarkar S., Paule M.G., and Raymick B.
J Neurosci Methods. 2012, 208(1): 40-3.

High-Throughput Identification of Molecular Targets of Brain Disorders Using Antibody-Based Microarray Analyses.
Gu Q.
Expert Rev Neurother. 2008, 8(9): 1281-3.

Experimental Approach for Assessing the Outcome Accuracy of Antibody Microarray Experiments.
Gu Q., Sivanandam T.M., and Haymore J.
J Proteome Res. 2007, 6(11): 4210-7.

Signal Stability of Cy3 and Cy5 on Antibody Microarrays.
Gu Q., Sivanandam T.M., and Kim C.A.
Proteome Sci. 2006, 4: 21.

Contribution of Acetylcholine to Visual Cortex Plasticity.
Gu Q.
Neurobiol Learn Mem. 2003, 80(3): 291-301.

Neuromodulatory Transmitter Systems in the Cortex and Their Role in Cortical Plasticity.
Gu Q.
Neuroscience. 2002, 111(4): 815-35.

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Lab Members

Bonnie Robinson
Lab technician
(870) 543-7391
NCTRResearch@fda.hhs.gov  

 

 

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Contact Information
Qiang Gu
(870) 543-7391
Expertise
Expertise
Approach
Domain
Technology & Discipline
Toxicology