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  1. Science & Research (NCTR)

NCTR Presentations at 2024 Society of Toxicology

Schedule of NCTR presentations at 63rd SOT Annual Meeting and ToxExpo, March 10-14, 2024

The SOT 63rd Annual Meeting and ToxExpo featured more than 70 scientific sessions, 2,000 presentations, 250 exhibitors, and 5,000 attendees.

2024 SOT Platform, Poster, or Workshop Sessions


NCTR Author

NCTR Division

ORAL PRESENTATION: Advancements in Cardiotoxicity Assessment "Developing Machine Learning and Deep Learning Models for Predicting hERG Blockade of Compounds to Assist Drug Safety Assessment" Hong, H. DBB
ORAL PRESENTATION: Advances in Mechanisms of Drug- and Diet-Induced Liver Injury "Development of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice" Willett, R. DBT
ORAL PRESENTATION: Nitrosamines: Mechanistic Evidence to Support Subclasses with Varying Mutagenic Potency "FDA N-nitrosamine drug impurity project" Heflich, R. DGMT
POSTER SESSION: Animal Models "Evaluation of Reproductive, Developmental, and Genetic Toxicities of Eugenol using Caenorhabditis elegans Model" Chen, T. DGMT
POSTER SESSION: Bioinformatics "Development of a BERT-Based Language Model for Extracting Adverse Events from Social Media Data" Fan, D. DBB
POSTER SESSION: Bioinformatics "Exploring Adverse Event Profiling in FDA Approved Monoclonal Antibody Drug Product by Using FDALabel" Ingle, T. OSC
POSTER SESSION: Bioinformatics "Assessing Quality of Drug Nomenclatures in RxNorm to Enhance Drug Safety Surveillance using Unstructured Data" Guo, W. DBB
POSTER SESSION: Bioinformatics "TransOrGAN: An Artificial Intelligence Mapping of Rat Transcriptomic Profiles between Organs, Ages, and Sexes" Li, T. DBB
POSTER SESSION: Cardiovascular Toxicology/Hemodynamics "Investigating the protective role of dexrazoxane against doxorubicin induced cardiotoxicity using human-induced pluripotent stem cell-derived cardiomyocytes" Bagam, P. DSB
POSTER SESSION: Computational Toxicology I "Using PBPK Modeling to Identify the Cause of Pharmacokinetic Differences between Sexes" Fairman, K. DBT
POSTER SESSION: Computational Toxicology I

"Drug Interaction with UGT Enzymes Is an Important Predictor of Drug-Induced Liver Injury"

Chen, M. DBB
POSTER SESSION: Computational Toxicology I "Developing a machine learning model to repurpose FDA approved drugs for the treatment of COVID-19" Liu, J. DBB
POSTER SESSION: Computational Toxicology I "A framework enabling LLMs into regulatory environment for transparency and trustworthy: A case study on drug labeling document" Wu, L. DBB
POSTER SESSION: Computational Toxicology I "DICTrank: The largest Dataset of Comprehensive Annotation for Drug-Induced Cardiotoxicity Using FDA Labeling Documents" Li, D. DBB
POSTER SESSION: Computational Toxicology I "Optimize in vitro assay based prediction models for drug toxicity by combining adverse outcome pathway (AOP) networks and the topological properties of Bayesian networks" Wang, D. DBB
POSTER SESSION: Developmental and Juvenile Toxicology "The effects of early life exposure to the chemotherapeutics cisplatin or methotrexate on adult measures of motivation, reversal learning, and attention in the rat" Talpos, J. DNT
POSTER SESSION: Epigenetics "Effect of food-grade titanium dioxide exposure on epigenetic outlook in human cells" Pogribny, M. DBT
POSTER SESSION: Genotoxicity/DNA Repair "In vitro mutagenicity assessment of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using High-Fidelity sequencing" Guo, X. DGMT
POSTER SESSION: Genotoxicity/DNA Repair "Assessment of In Vivo Chemical Mutagenesis by HiFi Sequencing" Miranda-Colon, J. DGMT
POSTER SESSION: Genotoxicity/DNA Repair "Mutagenicity and Genotoxicity of Twelve Nitrosamine Drug Substance-Related Impurities in Human TK6 Cells: Correlation with Enhanced Ames Test" Li, X. DGMT
POSTER SESSION: Genotoxicity/DNA Repair "Effects of Cisplatin on Erythrocyte PIG-A Mutation Frequencies of Cancer Patients" Pearce, M. DGMT
POSTER SESSION: Genotoxicity/DNA Repair "Determination of the Background Mutation Frequencies of TK6 and L5178Y Cell Cultures by Clone Sequencing" Revollo, J. DGMT
POSTER SESSION: Genotoxicity/DNA Repair "Application of Duplex Sequencing to Evaluate Mutagenicity of Aristolochic Acid and Methapyrilene in Fisher 344 Rats" Chen, T. DGMT
POSTER SESSION: Immunotoxicity II "Survey of Sex-Based Immune Differences following Food-Grade Titanium Dioxide Exposure in Human Peripheral Blood Mononuclear Cells and Plasma" Canup, B. DBT
POSTER SESSION: Liver: In Vivo "Transcriptomic alterations associated with the progression of nonalcoholic fatty liver disease in CC042 Collaborative Cross mice" Tryndyak, V. DBT
POSTER SESSION: Medical Devices "Evaluation of the Ability of the In Vitro Reconstructed Human Epidermis (RhE) Irritation Assay to Predict the Irritation Potential of Medical Devices Compared with the In Vivo Intracutaneous Reactivity Assay per ISO 10993-23"

Silva, C., Kudlyk, N., Twaddle, N., and Camacho, L. (Presented by S. Skoog, FDA/CDRH)

POSTER SESSION: Natural Products "Luteolin-Induced Cytotoxicity and Genotoxicity in Human Lymphoblastoid TK6 Cells" Mei, N. DGMT
POSTER SESSION: Neurotoxicity: Developmental II "Assessing the Developmental Effects of Fentanyl Using Neural Stem Cell Models" Wang, C. DNT
POSTER SESSION: Neurotoxicity: Developmental II "Investigation of the Developmental Neurotoxicity of Opioids using Human Induced Pluripotent Stem Cells (hiPSCs)" Cai, C. DSB
POSTER SESSION: Neurotoxicity: General "Combined tissue-clearing and Fluoro-Gold for brain vasculature labeling" Gu, Q. DNT
POSTER SESSION: Neurotoxicity: General "SARS-Co V-2 614G induced marked neurodegeneration and microglial activation in K18-hACE2 mice compared to more recent variants" Mercer, K. DSB
POSTER SESSION: New Approach Methods: Computational "Comparing Conventional Machine Learning Models with Generative AI in Predictive Toxicology" Chen, X. DBT
POSTER SESSION: New Approach Methods: In Vitro I "Donor-dependent responses to acetaminophen in human primary liver cells cultured in a liver microphysiological system" Shi, Q. DSB
POSTER SESSION: Respiratory Toxicology I "SARS-CoV-2 614G, Delta and BA.1 Induce Distinct Organ-Specific Pathology in K18-hACE2 Transgenic Mice" Masters, E. DSB
POSTER SESSION: Reproductive Toxicology I "Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells" Li, Y. DBT
POSTER SESSION: Skin "Permeation of Select Dermatological Product Ingredients Through Diverse Skin Types In Vitro"

Salminen, A.T.,  Felton, R.P., Twaddle, N.C., Davis, K.J., Elkins, L., Beland, F.A., An, N., Zang, Y., Srinivasan, J., Katz, L.M., Manga, P., and Camacho, L.

(Presenter: L. Camacho)

POSTER SESSION: Stem Cell Biology and Toxicology "Predicting Oncology Drug-Induced Cardiotoxicity with Donor-Specific iPSC-CMs - A Proof-of-Concept Study with Doxorubicin" Pang, L. DSB
POSTER SESSION: Late-Breaking 1 "The Landscape of Fusion Transcripts in Reference Samples Characterized by Targeted RNA Sequencing" Xu, J. DBB
POSTER SESSION: Late-Breaking 2 "Integration of RNA Expression to Evaluate the Developmental Toxicity of Busulfan in Human Embryonic Stem Cells" Wang, Y. DGMT
POSTER SESSION: Late-Breaking 2 "Evaluation of the Developmental Toxicity of Busulfan in an in vitro Human Placental Barrier-embryo Co-culture System" Wang, Y. (Presenting Author: Y. Chen) DGMT
POSTER SESSION: Late-Breaking 3 "Comparison of miRNA and Proteomics Profiles in COVID-19 Patients with Mild, Moderate, and Severe Symptoms" Beger, R. (Presenting Author: Q. Shi) DSB
POSTER SESSION: Late-Breaking 3 "Reshaping the gut microbial ecosystem: Impact of gestational antiretrovirals exposure on short chain fatty acid producers in aged rat offspring" Mohan Reddy Muthumula, C.  DM
POSTER SESSION: Late-Breaking 4 "Comparison of the Inhalation Toxicity of Ortho-Phthalaldehyde in a Human Air-Liquid Interface Airway Model using Two Aerosol Exposure Systems" Sun, Y. DGMT
POSTER SESSION: Late-Breaking 6 "Assessing the Effects of Methadone, Buprenorphine, and Nicotine on Human Neural Stem Cells" Liu, F. DNT
POSTER SESSION: Late-Breaking 7 "Evaluation of the Genotoxicity of Ortho-Phthalaldehyde in a Human In Vitro Organotypic Airway Tissue Model and Human Lymphoblastoid TK6 Cells" Yuan, L. DGMT
SYMPOSIUM SESSION: Looking through the Haze: Is the Picture Any Clearer on the Effects of Cannabis and Cannabis-Related Products on Reproduction and Development? "Cannabidiol and Its Main Metabolites Induced Toxicity in Mouse and Human Sertoli Cells" Chen, S. DBT

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