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  8. NCTR Participation at 2023 SOT Annual Meeting
  1. Science & Research (NCTR)

NCTR Participation at 2023 SOT Annual Meeting

Society of Toxicology (SOT) Annual Meeting and ToxExpo, March 19-23, 2023

NCTR researchers presented 54 scientific posters and 4 scientific sessions/workshops at the SOT 62nd Annual Meeting and ToxExpo that had 5,000 attendees.

 

2023 SOT Platform, Poster, or Workshop Sessions

Title

NCTR Author

NCTR Division

POSTER SESSION: ALTERNATIVES TO MAMMALIAN MODELS I "Lessons Learned in Establishing a Reliable and Low-Cost Assay for Urea Production in Human Primary Hepatocytes Cultured in a Liver Chip for the Study of Drug Hepatotoxicity" Shi, Q. DSB
POSTER SESSION: ALTERNATIVES TO MAMMALIAN MODELS I "AnimalGAN: A Generative AI Alternative to Animal Clinical Pathology Testing" Chen, X. DBB
POSTER SESSION: ALTERNATIVES TO MAMMALIAN MODELS I "Cardiotoxicity Assessment of HESI Reference Compounds Using Human iPSC-CMs" Bagam, P. DSB
POSTER SESSION: ALTERNATIVES TO MAMMALIAN MODELS I "Performance of the Three-Dimensional HepaRG Micronucleus Assay for In Vitro Genotoxicity Testing" Guo, X. DGMT
POSTER SESSION: EPIDEMIOLOGY AND PUBLIC HEALTH "A Systematic Analysis and Data Mining of Opioid-Related Adverse Events Submitted to the FAERS Database" Le, H. DBB
POSTER SESSION: EPIDEMIOLOGY AND PUBLIC HEALTH "Assessment of Modified Sandwich Estimator for Generalized Estimating Equations with Application to Opioid Poisoning in MIMIC-IV ICU Patients" Rogers, P. DBB
POSTER SESSION: EPIDEMIOLOGY AND PUBLIC HEALTH "RxNorm for Drug Name Normalization: A Case Study of Prescription Opioids in the US FDA Adverse Events Reporting System" Zou, W. DBB
POSTER SESSION: REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY I "Assessing the Developmental Toxicity of Busulfan in an In Vitro Human Placental Barrier-Embryo Co-culture System" Wang, Y. DGMT
POSTER SESSION: CARCINOGENICITY "DNA Methylation and Transcriptomic Alterations Induced by Extended Treatment of Normal Human MCF10A Mammary Gland Epithelial Cells with Non-cytotoxic Doses of Lorcaserin" Willett, R. DBT
PLATFORM SESSION: EXPLORING TIME AND CELL DIVERSITY IN TOXICOGENOMICS SPACE

"Effect of Food-Grade Titanium Dioxide on DNA Methylation in Human Cells"

Wells, C. DBT
WORKSHOP SESSION: UNDERSTANDING THE CONCEPT OF SIMILARITY AND ITS APPLICATIONS TO TOXICOLOGICAL RESEARCH AND RISK ASSESSMENT "Structure Similarity Based on Chemical Descriptors, Fingerprints, and Structural Alerts" Hong, H. DBB
POSTER SESSION: DNA DAMAGE AND REPAIR "Evaluation of Newly Developed 14 Human TK6-Derived Cell Lines That Individually Express a Human Cytochrome P450 for Toxicity Studies" Mei, N. DGMT
POSTER SESSION: DNA DAMAGE AND REPAIR "Nitrosamine Drug Impurities Induce Genotoxicity in Human Lymphoblastoid TK6 Cells" Li, X. DGMT
POSTER SESSION: DNA DAMAGE AND REPAIR "Actein Contributes to Black Cohosh Extract-Induced Genotoxicity in Human TK6 Cells" Le, Y. DGMT
POSTER SESSION: DNA DAMAGE AND REPAIR "Assessment of DNA Damage-Induced by 10 Nitrosamine Impurities Using 2D and 3D HepaRG Models" Seo, J.-E. DGMT
POSTER SESSION: DNA DAMAGE AND REPAIR "Evaluation of the DNA Mutagenicity of N-hydroxycytidine in Mouse Lymphoma Cells by HiFi and Clone Sequencing" Revollo, J. DGMT
POSTER SESSION: DNA DAMAGE AND REPAIR "HiFi Sequencing for Detecting In Vivo Somatic Mutation" Dobrovolsky, V. DGMT
POSTER SESSION: DNA DAMAGE AND REPAIR "HiFi Sequencing Detects the On- and Off-Target Effects of a Cytosine-to-Thymine Base Editor in E. coli" Miranda, J. DGMT
POSTER SESSION: BIOTRANSFORMATION/CYTOCHROME P450 "Study of the Roles of Cytochrome P450 (CYPs) in the Metabolism and Cytotoxicity of Perhexiline" Chen, S. DBT
POSTER SESSION: COMPUTATIONAL TOXICOLOGY I "Using Language Model to Facilitate COVID-19-Associated Neurological Disorder Literature Analysis: A BERTox Research" Wu, L. DBB
POSTER SESSION: COMPUTATIONAL TOXICOLOGY I "Development of Random Forest Model for Predicting SARS-CoV-2 Main Protease Binders as Potential Candidates for Repurposing to COVID-19 Treatment" Xu, L. DBB
POSTER SESSION: COMPUTATIONAL TOXICOLOGY I "Opioid Agonist/Antagonist Database (OADB): A Database to Facilitate Opioid Drug Development" Dong, F. DBB
POSTER SESSION: COMPUTATIONAL TOXICOLOGY I "Machine Learning Models for Rat Multigeneration Reproductive Toxicity Prediction" Liu, J. DBB
POSTER SESSION: COMPUTATIONAL TOXICOLOGY II "Machine Learning for Predicting Risk of Drug-Induced Autoimmune Diseases by Structural Alerts and Daily Dose" Chen, M. DBB
POSTER SESSION: SYSTEMS BIOLOGY "Assessment of the Toxicity of Cannabidiol (CBD) in Rats upon Oral Developmental Exposure" Camacho, L. DBT
POSTER SESSION: REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY III "Cannabidiol-Induced Transcriptomic Changes and Cellular Senescence in Human Sertoli Cells" Li, Y. DBT
POSTER SESSION: REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY III "COVID-19 Effects on Pregnancy, Prenatal, and Postnatal Development" Bidarimath, M. DSB
POSTER SESSION: SAFETY ASSESSMENT: PHARMACEUTICAL-DRUG DEVELOPMENT II "Obtain Drug Safety Rankings through Meta-analysis of Clinical Trial Data Using Penalized Bayesian Model" Wang, D. DBB
POSTER SESSION: BIOMARKERS "T2-MRI Mapping as a Minimally Invasive Correlate of Central Nervous System (CNS) Toxicity in a Cuprizone Model: A Biomarker Study" Imam, S. DNT
POSTER SESSION: EPIGENETICS "Effect of the Weight-Loss Drug Lorcaserin on DNA Methylation in Mammary Glands of Sprague Dawley Rats" Roudachevski, I. DBT
PLATFORM SESSION: ENHANCING TOXICOLOGY WITH MACHINE LEARNING "PathologAI - A Deep Learning Framework for Whole Slide Classification in Preclinical Pathology" Xu, J. DBB
POSTER SESSION: ALTERNATIVES TO MAMMALIAN MODELS II
Chair: Qiang Shi (DSB)
"Whole Genome Sequencing Analysis of Mutagenicity of N-Nitrosodiethylamine Using Caenorhabditis elegans Models" Chen, T. DGMT
POSTER SESSION: BIOINFORMATICS "Deep Learning-Based Genotype Imputation for Enhancing Toxicogenomic Data" Song, M. DBB
POSTER SESSION: BIOINFORMATICS "Statistical Methods for Exploring Spontaneous Adverse Event Reporting Databases for Drug-Host Factor Interactions" Lu, Z. DBB
POSTER SESSION: BIOINFORMATICS "Development of a Large List of Drugs for the Study of Nephrotoxicity in Drug Discovery" Connor, S. DBB
POSTER SESSION: BIOINFORMATICS "Random Forest Model for Predicting μ Opioid Receptor Binding Activity for Assisting Development of Opioid Drugs" Li, Z. DBB
POSTER SESSION: BIOINFORMATICS "DeepAmes: Deep Learning-Powered Ames Test Prediction Using Model-Level Representation" Li, T. DBB
POSTER SESSION: RISK ASSESSMENT II "Informing Selection of Drugs for COVID-19 Treatment through Analysis of Adverse Events" Guo, W.  DBB
POSTER SESSION: NEUROTOXICITY: DEVELOPMENTAL I "Cytokine-Mediated Chemotherapy-Induced Cognitive Impairment in Cisplatin and Methotrexate Treated Sprague Dawley Rats" Yeary, J. DNT
POSTER SESSION: NEUROTOXICITY: DEVELOPMENTAL I "Examining Immune Modulatory Effects of Perinatal Cannabidiol Exposure in Sprague Dawley Rats" Gill, W. DNT
POSTER SESSION: NEUROTOXICITY: DEVELOPMENTAL I "The Neurotoxic Potential of a Single Dose of Ketamine in Adolescent and Adult Rats" Talpos, J. DNT
POSTER SESSION: NEUROTOXICITY: DEVLEOPMENTAL II "Behavioral Effects of Cisplatin and Methotrexate Treatment in Juvenile Sprague Dawley Rats" Flanigan, T. DNT
POSTER SESSION: NEUROTOXICITY: DEVLEOPMENTAL II "Investigation of the Developmental Neurotoxicity of Opioids Using Human-Induced Pluripotent Stem Cells" Cai, C. DSB
POSTER SESSION: NEUROTOXICITY: GENERAL "A Modified Approach of Fluoro-Jade C Labeling for Neurotoxicity Assessments" Gu, Q. DNT
POSTER SESSION: IMMUNOTOXICITY I "Sex-Based Differences in Inflammatory Responses to Silver Nanoparticles" Canup, B. DBT
WORKSHOP SESSION 1195: MOVING STEM CELL-DERIVED NEW APPROACH METHODS TOWARD REGULATORY ACCEPTANCE
Chair: Li Pang (DSB)
"Predicting Interindividual Variability of Doxorubicin Cardiotoxicity with Induced Pluripotent Stem Cell-Derived Cardiomyocytes" Pang, L. DSB
POSTER SESSION: BIOLOGICAL MODELING "A Multiscale Physiologically Based Pharmacokinetic (PBPK) Model to Predict the Plasma Concentration and the Tissue Distribution of Doxorubicin" Li, M. DBT
POSTER SESSION: BIOLOGICAL MODELING "Using Various Machine-Learning Algorithms to Determine the Best Method for Predicting Population Physiologically Based Pharmacokinetic Model Plasma Profiles" Fairman, K. DBT
POSTER SESSION: KIDNEY "Evaluating Renal Pathology in Post-COVID-19 Human Autopsy Tissues" Masters, E. DSB
POSTER SESSION: SKIN AND DERMAL TOXICITY "Parallel Evaluation of Alternative Skin Barrier Models and Excised Human Skin for Dermal Absorption Studies In Vitro" Salminen, A. DBT
POSTER SESSION: LIVER I: IN VIVO
Chair: Si Chen (DBT)
"Gene Expression Changes Predict the Severity of NAFLD-Like Liver Injury in Male Collaborative Cross Mice" Tryndyak, V. DBT
POSTER SESSION: LIVER II: IN VIVO "hnRNP-Q and hnRNP-L Influence Drug Metabolism and Toxicity by Regulating mRNA Processing of Drug Metabolizing Enzymes and Nuclear Receptors in HepaRG Cells" Li, D. DBB
POSTER SESSION: LIVER II: IN VIVO "hnRMP-Q and hnRMP-L Influence Drug Metabolism and Toxicity by Regulating mRNA Processing of Drug Metabolizing Enzymes and Nuclear Receptors in HepaRG Cells" Li, D. DBB
POSTER SESSION: RESPIRATORY TOXICOLOGY I "Establishing a Continuous Aerosol Exposure Method for Evaluating the Respiratory Toxicity of Ortho-Phthalaldehyde" Sun, Y. DGMT
POSTER SESSION: LATE-BREAKING 2-4 "Potential Link of High-Fat Diet on the Expression of Alzheimer’s Disease-Related Genes in the Ileal Mucosa of Alzheimer’s Disease Model of Rats" Karn, K. DM
POSTER SESSION: LATE-BREAKING 2-4 "The Effects of Cannabidiol and Its Main Metabolites on Human Neural Stem Cells" Latham, L. DNT
POSTER SESSION: LATE-BREAKING 2-4 "Comparison of the Effects of Delta-9 Tetrahydrocannabinol and Cannabidiol on Human Neural Stem Cells" Liu, F. DNT
POSTER SESSION: LATE-BREAKING 2-4 "Assessment of Potential Developmental Neurotoxicity of Purified Cannabidiol in Sprague Dawley Rats" Shen, A. DNT

 

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