NCTR Participation at 2023 SOT Annual Meeting
Society of Toxicology (SOT) Annual Meeting and ToxExpo, March 19-23, 2023
NCTR researchers presented 54 scientific posters and 4 scientific sessions/workshops at the SOT 62nd Annual Meeting and ToxExpo that had 5,000 attendees.
NCTR researchers presented 54 scientific posters and 4 scientific sessions/workshops at the SOT 62nd Annual Meeting and ToxExpo that had 5,000 attendees.
2023 SOT Platform, Poster, or Workshop Sessions |
Title |
NCTR Author |
NCTR Division |
|---|---|---|---|
| POSTER SESSION: ALTERNATIVES TO MAMMALIAN MODELS I | "Lessons Learned in Establishing a Reliable and Low-Cost Assay for Urea Production in Human Primary Hepatocytes Cultured in a Liver Chip for the Study of Drug Hepatotoxicity" | Shi, Q. | DSB |
| POSTER SESSION: ALTERNATIVES TO MAMMALIAN MODELS I | "AnimalGAN: A Generative AI Alternative to Animal Clinical Pathology Testing" | Chen, X. | DBB |
| POSTER SESSION: ALTERNATIVES TO MAMMALIAN MODELS I | "Cardiotoxicity Assessment of HESI Reference Compounds Using Human iPSC-CMs" | Bagam, P. | DSB |
| POSTER SESSION: ALTERNATIVES TO MAMMALIAN MODELS I | "Performance of the Three-Dimensional HepaRG Micronucleus Assay for In Vitro Genotoxicity Testing" | Guo, X. | DGMT |
| POSTER SESSION: EPIDEMIOLOGY AND PUBLIC HEALTH | "A Systematic Analysis and Data Mining of Opioid-Related Adverse Events Submitted to the FAERS Database" | Le, H. | DBB |
| POSTER SESSION: EPIDEMIOLOGY AND PUBLIC HEALTH | "Assessment of Modified Sandwich Estimator for Generalized Estimating Equations with Application to Opioid Poisoning in MIMIC-IV ICU Patients" | Rogers, P. | DBB |
| POSTER SESSION: EPIDEMIOLOGY AND PUBLIC HEALTH | "RxNorm for Drug Name Normalization: A Case Study of Prescription Opioids in the US FDA Adverse Events Reporting System" | Zou, W. | DBB |
| POSTER SESSION: REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY I | "Assessing the Developmental Toxicity of Busulfan in an In Vitro Human Placental Barrier-Embryo Co-culture System" | Wang, Y. | DGMT |
| POSTER SESSION: CARCINOGENICITY | "DNA Methylation and Transcriptomic Alterations Induced by Extended Treatment of Normal Human MCF10A Mammary Gland Epithelial Cells with Non-cytotoxic Doses of Lorcaserin" | Willett, R. | DBT |
| PLATFORM SESSION: EXPLORING TIME AND CELL DIVERSITY IN TOXICOGENOMICS SPACE |
"Effect of Food-Grade Titanium Dioxide on DNA Methylation in Human Cells" |
Wells, C. | DBT |
| WORKSHOP SESSION: UNDERSTANDING THE CONCEPT OF SIMILARITY AND ITS APPLICATIONS TO TOXICOLOGICAL RESEARCH AND RISK ASSESSMENT | "Structure Similarity Based on Chemical Descriptors, Fingerprints, and Structural Alerts" | Hong, H. | DBB |
| POSTER SESSION: DNA DAMAGE AND REPAIR | "Evaluation of Newly Developed 14 Human TK6-Derived Cell Lines That Individually Express a Human Cytochrome P450 for Toxicity Studies" | Mei, N. | DGMT |
| POSTER SESSION: DNA DAMAGE AND REPAIR | "Nitrosamine Drug Impurities Induce Genotoxicity in Human Lymphoblastoid TK6 Cells" | Li, X. | DGMT |
| POSTER SESSION: DNA DAMAGE AND REPAIR | "Actein Contributes to Black Cohosh Extract-Induced Genotoxicity in Human TK6 Cells" | Le, Y. | DGMT |
| POSTER SESSION: DNA DAMAGE AND REPAIR | "Assessment of DNA Damage-Induced by 10 Nitrosamine Impurities Using 2D and 3D HepaRG Models" | Seo, J.-E. | DGMT |
| POSTER SESSION: DNA DAMAGE AND REPAIR | "Evaluation of the DNA Mutagenicity of N-hydroxycytidine in Mouse Lymphoma Cells by HiFi and Clone Sequencing" | Revollo, J. | DGMT |
| POSTER SESSION: DNA DAMAGE AND REPAIR | "HiFi Sequencing for Detecting In Vivo Somatic Mutation" | Dobrovolsky, V. | DGMT |
| POSTER SESSION: DNA DAMAGE AND REPAIR | "HiFi Sequencing Detects the On- and Off-Target Effects of a Cytosine-to-Thymine Base Editor in E. coli" | Miranda, J. | DGMT |
| POSTER SESSION: BIOTRANSFORMATION/CYTOCHROME P450 | "Study of the Roles of Cytochrome P450 (CYPs) in the Metabolism and Cytotoxicity of Perhexiline" | Chen, S. | DBT |
| POSTER SESSION: COMPUTATIONAL TOXICOLOGY I | "Using Language Model to Facilitate COVID-19-Associated Neurological Disorder Literature Analysis: A BERTox Research" | Wu, L. | DBB |
| POSTER SESSION: COMPUTATIONAL TOXICOLOGY I | "Development of Random Forest Model for Predicting SARS-CoV-2 Main Protease Binders as Potential Candidates for Repurposing to COVID-19 Treatment" | Xu, L. | DBB |
| POSTER SESSION: COMPUTATIONAL TOXICOLOGY I | "Opioid Agonist/Antagonist Database (OADB): A Database to Facilitate Opioid Drug Development" | Dong, F. | DBB |
| POSTER SESSION: COMPUTATIONAL TOXICOLOGY I | "Machine Learning Models for Rat Multigeneration Reproductive Toxicity Prediction" | Liu, J. | DBB |
| POSTER SESSION: COMPUTATIONAL TOXICOLOGY II | "Machine Learning for Predicting Risk of Drug-Induced Autoimmune Diseases by Structural Alerts and Daily Dose" | Chen, M. | DBB |
| POSTER SESSION: SYSTEMS BIOLOGY | "Assessment of the Toxicity of Cannabidiol (CBD) in Rats upon Oral Developmental Exposure" | Camacho, L. | DBT |
| POSTER SESSION: REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY III | "Cannabidiol-Induced Transcriptomic Changes and Cellular Senescence in Human Sertoli Cells" | Li, Y. | DBT |
| POSTER SESSION: REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY III | "COVID-19 Effects on Pregnancy, Prenatal, and Postnatal Development" | Bidarimath, M. | DSB |
| POSTER SESSION: SAFETY ASSESSMENT: PHARMACEUTICAL-DRUG DEVELOPMENT II | "Obtain Drug Safety Rankings through Meta-analysis of Clinical Trial Data Using Penalized Bayesian Model" | Wang, D. | DBB |
| POSTER SESSION: BIOMARKERS | "T2-MRI Mapping as a Minimally Invasive Correlate of Central Nervous System (CNS) Toxicity in a Cuprizone Model: A Biomarker Study" | Imam, S. | DNT |
| POSTER SESSION: EPIGENETICS | "Effect of the Weight-Loss Drug Lorcaserin on DNA Methylation in Mammary Glands of Sprague Dawley Rats" | Roudachevski, I. | DBT |
| PLATFORM SESSION: ENHANCING TOXICOLOGY WITH MACHINE LEARNING | "PathologAI - A Deep Learning Framework for Whole Slide Classification in Preclinical Pathology" | Xu, J. | DBB |
| POSTER SESSION: ALTERNATIVES TO MAMMALIAN MODELS II Chair: Qiang Shi (DSB) |
"Whole Genome Sequencing Analysis of Mutagenicity of N-Nitrosodiethylamine Using Caenorhabditis elegans Models" | Chen, T. | DGMT |
| POSTER SESSION: BIOINFORMATICS | "Deep Learning-Based Genotype Imputation for Enhancing Toxicogenomic Data" | Song, M. | DBB |
| POSTER SESSION: BIOINFORMATICS | "Statistical Methods for Exploring Spontaneous Adverse Event Reporting Databases for Drug-Host Factor Interactions" | Lu, Z. | DBB |
| POSTER SESSION: BIOINFORMATICS | "Development of a Large List of Drugs for the Study of Nephrotoxicity in Drug Discovery" | Connor, S. | DBB |
| POSTER SESSION: BIOINFORMATICS | "Random Forest Model for Predicting μ Opioid Receptor Binding Activity for Assisting Development of Opioid Drugs" | Li, Z. | DBB |
| POSTER SESSION: BIOINFORMATICS | "DeepAmes: Deep Learning-Powered Ames Test Prediction Using Model-Level Representation" | Li, T. | DBB |
| POSTER SESSION: RISK ASSESSMENT II | "Informing Selection of Drugs for COVID-19 Treatment through Analysis of Adverse Events" | Guo, W. | DBB |
| POSTER SESSION: NEUROTOXICITY: DEVELOPMENTAL I | "Cytokine-Mediated Chemotherapy-Induced Cognitive Impairment in Cisplatin and Methotrexate Treated Sprague Dawley Rats" | Yeary, J. | DNT |
| POSTER SESSION: NEUROTOXICITY: DEVELOPMENTAL I | "Examining Immune Modulatory Effects of Perinatal Cannabidiol Exposure in Sprague Dawley Rats" | Gill, W. | DNT |
| POSTER SESSION: NEUROTOXICITY: DEVELOPMENTAL I | "The Neurotoxic Potential of a Single Dose of Ketamine in Adolescent and Adult Rats" | Talpos, J. | DNT |
| POSTER SESSION: NEUROTOXICITY: DEVLEOPMENTAL II | "Behavioral Effects of Cisplatin and Methotrexate Treatment in Juvenile Sprague Dawley Rats" | Flanigan, T. | DNT |
| POSTER SESSION: NEUROTOXICITY: DEVLEOPMENTAL II | "Investigation of the Developmental Neurotoxicity of Opioids Using Human-Induced Pluripotent Stem Cells" | Cai, C. | DSB |
| POSTER SESSION: NEUROTOXICITY: GENERAL | "A Modified Approach of Fluoro-Jade C Labeling for Neurotoxicity Assessments" | Gu, Q. | DNT |
| POSTER SESSION: IMMUNOTOXICITY I | "Sex-Based Differences in Inflammatory Responses to Silver Nanoparticles" | Canup, B. | DBT |
| WORKSHOP SESSION 1195: MOVING STEM CELL-DERIVED NEW APPROACH METHODS TOWARD REGULATORY ACCEPTANCE Chair: Li Pang (DSB) |
"Predicting Interindividual Variability of Doxorubicin Cardiotoxicity with Induced Pluripotent Stem Cell-Derived Cardiomyocytes" | Pang, L. | DSB |
| POSTER SESSION: BIOLOGICAL MODELING | "A Multiscale Physiologically Based Pharmacokinetic (PBPK) Model to Predict the Plasma Concentration and the Tissue Distribution of Doxorubicin" | Li, M. | DBT |
| POSTER SESSION: BIOLOGICAL MODELING | "Using Various Machine-Learning Algorithms to Determine the Best Method for Predicting Population Physiologically Based Pharmacokinetic Model Plasma Profiles" | Fairman, K. | DBT |
| POSTER SESSION: KIDNEY | "Evaluating Renal Pathology in Post-COVID-19 Human Autopsy Tissues" | Masters, E. | DSB |
| POSTER SESSION: SKIN AND DERMAL TOXICITY | "Parallel Evaluation of Alternative Skin Barrier Models and Excised Human Skin for Dermal Absorption Studies In Vitro" | Salminen, A. | DBT |
| POSTER SESSION: LIVER I: IN VIVO Chair: Si Chen (DBT) |
"Gene Expression Changes Predict the Severity of NAFLD-Like Liver Injury in Male Collaborative Cross Mice" | Tryndyak, V. | DBT |
| POSTER SESSION: LIVER II: IN VIVO | "hnRNP-Q and hnRNP-L Influence Drug Metabolism and Toxicity by Regulating mRNA Processing of Drug Metabolizing Enzymes and Nuclear Receptors in HepaRG Cells" | Li, D. | DBB |
| POSTER SESSION: LIVER II: IN VIVO | "hnRMP-Q and hnRMP-L Influence Drug Metabolism and Toxicity by Regulating mRNA Processing of Drug Metabolizing Enzymes and Nuclear Receptors in HepaRG Cells" | Li, D. | DBB |
| POSTER SESSION: RESPIRATORY TOXICOLOGY I | "Establishing a Continuous Aerosol Exposure Method for Evaluating the Respiratory Toxicity of Ortho-Phthalaldehyde" | Sun, Y. | DGMT |
| POSTER SESSION: LATE-BREAKING 2-4 | "Potential Link of High-Fat Diet on the Expression of Alzheimer’s Disease-Related Genes in the Ileal Mucosa of Alzheimer’s Disease Model of Rats" | Karn, K. | DM |
| POSTER SESSION: LATE-BREAKING 2-4 | "The Effects of Cannabidiol and Its Main Metabolites on Human Neural Stem Cells" | Latham, L. | DNT |
| POSTER SESSION: LATE-BREAKING 2-4 | "Comparison of the Effects of Delta-9 Tetrahydrocannabinol and Cannabidiol on Human Neural Stem Cells" | Liu, F. | DNT |
| POSTER SESSION: LATE-BREAKING 2-4 | "Assessment of Potential Developmental Neurotoxicity of Purified Cannabidiol in Sprague Dawley Rats" | Shen, A. | DNT |