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  8. Gonçalo Gamboa da Costa
  1. National Center for Toxicological Research

Gonçalo Gamboa da Costa Ph.D.

 

Research Chemist — Division of Biochemical Toxicology

Gonçalo Gamboa da Costa
Gonçalo Gamboa da Costa, Ph.D.

(870) 543-7391
NCTRResearch@fda.hhs.gov

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About  |  Publications  |  Lab Members


Background

Dr. Gonçalo Gamboa da Costa is a research chemist at NCTR. He received his bachelor’s in biology from the University of Lisbon, Portugal, followed by an M.S. in technologic organic chemistry from the New University of Lisbon, Portugal, and a Ph.D. in organic chemistry from the Technical University of Lisbon, Portugal. Following a postdoctoral appointment at the Institute of Cancer Research, Sutton, UK, Dr. Gamboa da Costa became Director of the Laboratory of Mass Spectrometry and Nuclear Magnetic Resonance at NCTR. Dr. Gamboa da Costa has been the principal investigator for several toxicological studies sponsored by the National Institutes of Environmental Health Sciences (NIEHS)/National Toxicology Program (NTP). His area of expertise is the implementation of mass-spectral based analytical methodologies to elucidate mechanisms of toxicity. Dr. Gamboa da Costa serves as the FDA Liaison Officer to the NTP.

Research Interests

Dr. Gamboa da Costa’s research interests are focused on the in-depth toxicological evaluation of food adulterants and food additives. He is the principal investigator of key toxicological studies sponsored by NTP aiming to clarify the combined toxicity of melamine and cyanuric acid. These food adulterants were implicated in the kidney illness and death of large numbers of cats and dogs in the U.S. in 2007, as well as the deaths of at least six infants and the hospitalization of an estimated 300,000 infants in China in 2008. The outcome of Dr. Gamboa da Costa’s research is expected to play a key role in the refinement of the current FDA risk assessment for melamine and derivatives. He has also recently initiated studies that aim to clarify certain toxicological aspects of the food additive, brominated vegetable oil.

The studies conducted by Dr. Gamboa da Costa typically encompass, not only guideline endpoints such as histopathology and clinical chemistry, but also additional endpoints such as the toxicokinetic evaluation of the parent toxicant and its metabolites or the quantification of covalent DNA adducts stemming from genotoxicants, enabling a more comprehensive evaluation of the mechanisms of toxicity.

Given Dr. Gamboa da Costa’s expertise in synthetic organic chemistry and mass spectral-based analytical methodologies, he is regularly invited to collaborate with national and international research teams on a breadth of aspects in the domain of toxicology. He is actively collaborating with research teams in the U.S., Canada, and a number of European countries.


Professional Societies/National and International Groups

American Society for Mass Spectrometry
Member
2009 – Present

Society of Toxicology
Member
2008 – Present

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Selected Publications

Simple and Rapid Quantification of Brominated Vegetable Oil in Commercial Soft Drinks by LC-MS.
Chitranshi P. and Gamboa da Costa G.
Food Chem. 2016 Dec 15, 213:567-70.
 

Effects of a 28-day Dietary Co-Exposure to Melamine and Cyanuric Acid on the Levels of Serum MicroRNAs in Male and Female Fisher 344 Rats.
Silva C., Chang C., Williams D., Porter-Gill P., Gamboa da Costa G. and Camacho L.
Food Chem Toxicol. 2016 Sep 9, pii: S0278-6915(16)30328-3.
 

Toxicity Evaluation of Bisphenol A Administered by Gavage to Sprague Dawley Rats From Gestation Day 6 Through Postnatal Day 90.
Delclos K., Camacho L., Lewis S., Vanlandingham M., Latendresse J., Olson G., Davis K., Patton R., Gamboa da Costa G., Woodling K., Bryant M., Chidambaram M., Trbojevich R., Juliar B., Felton R. and Thorn B.
Toxicol Sci. 2016 Sep, 153(1):212.
 

Sulfotransferases Enhance the Cytotoxicity of Tolvaptan.
Fang J., Wu Y., Gamboa da Costa G., Chen S., Chitranshi P. and Beland F.
Toxicol Sci. 2016 Mar, 150(1):27-39.
 

Metabolic Activation of 2-Amino-1-Methyl-6-Phenylimidazo [4,5-b]Pyridine and DNA Adduct Formation Depends on p53: Studies in Trp53(+/+),Trp53(+/-) and Trp53(-/-) Mice.
Krais A., Speksnijder E., Melis J., Singh R., Caldwell A., Gamboa da Costa G., Luijten M., Phillips D. and Arlt V.
Int J Cancer. 2016 Feb 15, 138(4):976-82.
 

Evaluation of Serum and Liver Toxicokinetics for Furan and Liver DNA Adduct Formation in Male Fischer 344 Rats.
Churchwell M., Scheri R., Von Tungeln L., Gamboa da Costa G., Beland F. and Doerge D.
Food Chem Toxicol. 2015 Dec, 86:1-8.
 

Effects of Oral Exposure to Bisphenol A on Gene Expression and Global Genomic DNA Methylation in the Prostate, Female Mammary Gland, and Uterus of NCTR Sprague-Dawley Rats.
Camacho L., Basavarajappa M., Chang C., Han T., Kobets T., Koturbash I., Surratt G., Lewis S., Vanlandingham M., Fuscoe J., Gamboa da Costa G., Pogribny I. and Delclos K.
Food Chem Toxicol. 2015 Jul, 81:92-103.
 

Exceptionally Long-Term Persistence of DNA Adducts Formed by Carcinogenic Aristolochic Acid I in Renal Tissue from Patients with Aristolochic Acid Nephropathy.
Schmeiser H., Nortier J., Singh R., Gamboa da Costa G., Sennesael J., Cassuto-Viguier E., Ambrosetti D., Rorive S., Pozdzik A., Phillips D., Stiborova M. and Arlt V.
Int J Cancer. 2014 Jul 15, 135(2):502-7.
 

Modulation of Intracellular Iron Metabolism by Iron Chelation Affects Chromatin Remodeling Proteins and Corresponding Epigenetic Modifications in Breast Cancer Cells and Increases Their Sensitivity to Chemotherapeutic Agents.
Pogribny I., Tryndyak V., Pogribna M., Shpyleva S., Surratt G., Gamboa da Costa G. and Beland F.
Int J Oncol. 2013 May, 42(5):1822-32.
 

Performance of Urinary and Gene Expression Biomarkers in Detecting the Nephrotoxic Effects of Melamine and Cyanuric Acid Following Diverse Scenarios of Co-Exposure.
Bandele O., Camacho L., Ferguson M., Reimschuessel R., Stine C., Black T., Olejnik N., Keltner Z., Scott M., Gamboa da Costa G. and Sprando R.
Food Chem Toxicol. 2013 Jan, 51:106-13.
 

Timing and Route of Exposure Affects Crystal Formation in Melamine and Cyanuric Exposed Male and Female Rats: Gavage vs. Feeding.
Sprando R., Reimschuessel R., Stine C., Black T., Olejnik N., Scott M., Keltner Z., Bandele O., Ferguson M., Nemser S., Tkachenko A., Evans E., Crosby T., Woodling K., Loukotková L. and Gamboa da Costa G.
Food Chem Toxicol. 2012 Dec, 50(12):4389-97.
 

Urinary Biomarker Detection of Melamine and Cyanuric Acid-Induced Kidney Injury in Rats.
Zhang Q., Gamboa da Costa G., Von Tungeln L., Jacob C., Brown R. and Goering P.
Toxicol Sci. 2012 Sep, 129(1):1-8.
 

Dose-Response Assessment of Nephrotoxicity from a Twenty-Eight-Day Combined-Exposure to Melamine and Cyanuric Acid in F344 Rats.
Gamboa da Costa G., Jacob C., Von Tungeln L., Hasbrouck N., Olson G., Hattan D., Reimschuessel R. and Beland F.
T Toxicol Sci. 2012 Apr, 126(2):317-24.
 

Pharmacokinetics of Melamine and Cyanuric Acid and their Combinations in F344 Rats.
Jacob C., Von Tungeln L., Vanlandingham M., Beland F. and Gamboa da Costa G.
Toxicol Sci. 2012 Apr, 126(2):317-24.
 

Gene Expression of Biomarkers of Nephrotoxicity in F344 Rats Co-Exposed to Melamine and Cyanuric Acid for Seven Days.
Camacho L., Kelly K., Beland F. and Gamboa da Costa G.
Toxicol Lett. 2011 Oct 10, 206(2):166-71.
 

Low-Level Quantification of Melamine and Cyanuric Acid in Limited Samples of Rat Serum by UPLC-Electrospray Tandem Mass Spectrometry.
Jacob C. and Gamboa da Costa G.
J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Mar 15, 879(9-10):652-6.
 

Dose-Response Assessment of Nephrotoxicity from a 7-Day Combined Exposure to Melamine and Cyanuric Acid in F344 Rats.
Jacob C., Reimschuessel R., Von Tungeln L., Olson G., Warbritton A., Hattan D., Beland F. and Gamboa da Costa G.
Toxicol Sci. 2011 Feb, 119(2):391-7.
 

Detection and Quantitation of N-(Deoxyguanosin-8-yl)-2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine Adducts in DNA Using Online Column-Switching Liquid Chromatography Tandem Mass Spectrometry.
Singh R., Arlt V., Henderson C., Phillips D., Farmer P. and Gamboa da Costa G.
J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Aug 1, 878(23):2155-62.
 

Quantification of 3-Nitrobenzanthrone-DNA Adducts Using Online Column-Switching HPLC-Electrospray Tandem Mass Spectrometry.
Gamboa da Costa G., Singh R., Arlt V., Mirza A., Richards M., Takamura-Enya T., Schmeiser H., Farmer P. and Phillips D.
Chem Res Toxicol. 2009 Nov, 22(11):1860-8.
 

DNA Adduct Formation from Acrylamide via Conversion to Glycidamide in Adult and Neonatal Mice.
Gamboa da Costa G., Churchwell M., Hamilton L., Von Tungeln L., Beland F., Marques M. and Doerge D.
Chem Res Toxicol. 2003 Oct, 16(10):1328-37.
 

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Lab Members

Contact information for all lab members:
(870) 543-7391
NCTRResearch@fda.hhs.gov

Lucie Loukotková, Ph.D.
Chemist
 

Kellie A. Woodling, Ph.D.
Chemist
 

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Contact Information
Gonçalo Gamboa da Costa
(870) 543-7391