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  1. Science & Research (NCTR)

Gonçalo Gamboa da Costa Ph.D.

Senior Science Advisor — Office of the Center Director

Goncalo Gamboa da Costa, Ph.D.

Gonçalo Gamboa da Costa, Ph.D.
(870) 543-7121
NCTRResearch@fda.hhs.gov

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About  |  Publications  |  Lab Members

Background

Dr. Gonçalo Gamboa da Costa is a senior science advisor to the center director at FDA’s National Center for Toxicological Research (NCTR). He received a bachelor’s degree in biology from the University of Lisbon, Portugal, followed by an M.S. in technologic organic chemistry from the New University of Lisbon, Portugal, and a Ph.D. in organic chemistry from the Technical University of Lisbon, Portugal. Following a postdoctoral appointment at the Institute of Cancer Research, Sutton, United Kingdom, Dr. Gamboa da Costa became the director of the Laboratory of Mass Spectrometry and Nuclear Magnetic Resonance at NCTR. Dr. Gamboa da Costa has been the principal investigator for several toxicological studies sponsored by an Interagency Agreement between the National Institute of Environmental Health Sciences Division of Translational Toxicology and FDA/NCTR. His area of expertise is the implementation of mass spectral-based analytical methodologies to elucidate mechanisms of toxicity. Dr. Gamboa da Costa also serves as the FDA Liaison Officer to the National Toxicology Program, an FDA Representative in the International Liaison Group on Methods for Risk Assessment of Chemicals in Food, and an FDA representative in the Sustainable Chemistry Strategy Team, White House Office of Science and Technology Policy.

 

Research Interests

Dr. Gamboa da Costa’s current research interests are focused on the evaluation of new alternative methods (NAMs) to inform the regulatory decision-making process of the FDA. Dr. Gamboa da Costa’s combined background in toxicological sciences and chemistry provide him a broad understanding of the opportunities and challenges associated with the deployment of NAMs in a regulatory context and facilitate his participation in multiple ongoing national and international collaborative research efforts in this space.

 

Professional Societies/National and International Groups

American Society for Mass Spectrometry
Member
2009 – Present

International MPS (Microphysiological Systems) Society
Member
2024 – Present

Society of Toxicology
Member
2008 – Present

 

Selected Publications

Trust Your Gut: Establishing Confidence in Gastrointestinal Models - An Overview of the State of the Science and Contexts of Use.
Debad S., Allen D., Bandele O., Bishop C., Blaylock M., Brown P., Bunger M.K., Co J.Y., Crosby L., Daniel A.B., Ferguson S.S., Ford K., Gamboa da Costa G., Gilchrist K.H., Grogg M.W., Gwinn M., Hartung T., Hogan S.P., Jeong Y.E., Kass G.E., Kenyon E., Kleinstreuer N.C., Kujala V., Lundquist P., Matheson J., McCullough S.D., Melton-Celsa A., Musser S., Oh I., Oyetade O.B., Patil S.U., Petersen E.J., Sadrieh N., Sayes C.M., Scruggs B.S., Tan Y.M., Thelin B., Nelson M.T., Tarazona J.V., Wambaugh J.F., Yang J.Y., Yu C., and Fitzpatrick S.
ALTEX. 2024, 41(3):402-424.

The Effect of Black Cohosh Extract and Risedronate Coadministration on Bone Health in an Ovariectomized Rat Model.
Inselman A.L., Masters E.A., Moore J.N., Agarwal R., Gassman A., Kuijpers G., Beger R.D., Delclos K.B., Swift S., Camacho L., Vanlandingham M.M., Sloper D., Nakamura N., Gamboa da Costa G., Woodling K., Bryant M., Trbojevich R., Wu Q., McLellen F., and Christner D.
Front Pharmacol. 2024, 15:1365151.

Toxicological Evaluation of Brominated Vegetable Oil in Sprague Dawley Rats.
Woodling K.A., Chitranshi P., Jacob C.C., Loukotková L., Von Tungeln L.S., Olson G.R., Patton R.E., Francke S, Mog S.R., Felton R.P., Beland F.A., Zang Y., and Gamboa da Costa G.
Food Chem Toxicol. 2022, 165:113137.

Effects of Serum and Compound Preparation Methods on Delayed Repolarization Evaluation with Human iPSC-CMs.
Wei F., Pence L., Woodling K., Bagam P., Beger R., Gamboa da Costa G., and Pang L.
Toxicol Sci. 2022, 188(1):48-61.

Toxicity of High-Molecular-Weight Polyethylene Glycols in Sprague Dawley Rats.
Fang J.L., Vanlandingham M.M., Beland F.A., Felton R.P., Maisha M.P., Olson G.R., Patton R.E., Rosenberg A.S., and Gamboa da Costa G.
Toxicol Lett. 2022, 359:22-30.

Effect of Urinary pH upon the Renal Toxicity of Melamine and Cyanuric Acid.
Von Tungeln L.S., Jacob C.C., Olson G.R., Gamboa da Costa G., and Beland F.A.
J Environ Sci Health C Toxicol Carcinog. 2021, 39(3):340-355.

A Rapid and Highly Sensitive UPLC-ESI-MS/MS Method for the Analysis of the Fatty Acid Profile of Edible Vegetable Oils.
Nagumalli S.K, Jacob C.C., and Gamboa da Costa G.
J Chromatogr B. 2020, 1161:122415.

Pharmacokinetics of Oseltamivir Phosphate and Oseltamivir Carboxylate in Non-Pregnant and Pregnant Rhesus Monkeys.
Loukotková L., Basavarajappa M., Lumen A., Roberts R., Mattison D., Morris S.M., Fisher J., Beland F.A., and Gamboa da Costa., G.
Regul Toxicol Pharmacol. 2020, 112:104569.

A Two-Year Toxicology Study of Bisphenol A (BPA) in Sprague-Dawley Rats: CLARITY-BPA Core Study Results.
Camacho L., Lewis S.M., Vanlandingham M.M., Olson G.R., Davis, K.J., Patton, R.E., Twaddle N.C., Doerge D.R., Churchwell M.I., Bryant M.S., McLellen F.M., Woodling, K.A., Felton R.P., Maisha M.P., Juliar B.E., Gamboa da Costa G., and Delclos K.B.
Food Chem Toxicol. 2019, 132:110728.

Effects of Human Sulfotransferases on the Cytotoxicity of 12-Hydroxynevirapine.
Fang J-L, Loukotková L., Chitranshi P., Gamboa da Costa G., and Beland F.A.
Biochem Pharmacol. 2018, 155:455.

Simple and Rapid Quantification of Brominated Vegetable Oil in Commercial Soft Drinks by LC-MS.
Chitranshi P. and Gamboa da Costa G.
Food Chem. 2016, 213:567-70.

Toxicity Evaluation of Bisphenol A Administered by Gavage to Sprague Dawley Rats From Gestation Day 6 Through Postnatal Day 90.
Delclos K., Camacho L., Lewis S., Vanlandingham M., Latendresse J., Olson G., Davis K., Patton R., Gamboa da Costa G., Woodling K., Bryant M., Chidambaram M., Trbojevich R., Juliar B., Felton R., and Thorn B.
Toxicol Sci. 2016, 153(1):212.

Metabolic Activation of 2-Amino-1-Methyl-6-Phenylimidazo [4,5-b]Pyridine and DNA Adduct Formation Depends on p53: Studies in Trp53(+/+),Trp53(+/-) and Trp53(-/-) Mice.
Krais A., Speksnijder E., Melis J., Singh R., Caldwell A., Gamboa da Costa G., Luijten M., Phillips D., and Arlt V.
Int J Cancer. 2016, 138(4):976-82.

Evaluation of Serum and Liver Toxicokinetics for Furan and Liver DNA Adduct Formation in Male Fischer 344 Rats.
Churchwell M., Scheri R., Von Tungeln L., Gamboa da Costa G., Beland F., and Doerge D.
Food Chem Toxicol. 2015, 86:1-8.

Exceptionally Long-Term Persistence of DNA Adducts Formed by Carcinogenic Aristolochic Acid I in Renal Tissue from Patients with Aristolochic Acid Nephropathy.
Schmeiser H., Nortier J., Singh R., Gamboa da Costa G., Sennesael J., Cassuto-Viguier E., Ambrosetti D., Rorive S., Pozdzik A., Phillips D., Stiborova M., and Arlt V.
Int J Cancer. 2014, 135(2):502-7.

Performance of Urinary and Gene Expression Biomarkers in Detecting the Nephrotoxic Effects of Melamine and Cyanuric Acid Following Diverse Scenarios of Co-Exposure.
Bandele O., Camacho L., Ferguson M., Reimschuessel R., Stine C., Black T., Olejnik N., Keltner Z., Scott M., Gamboa da Costa G., and Sprando R.
Food Chem Toxicol. 2013, 51:106-13.

Timing and Route of Exposure Affects Crystal Formation in Melamine and Cyanuric Exposed Male and Female Rats: Gavage vs. Feeding.
Sprando R., Reimschuessel R., Stine C., Black T., Olejnik N., Scott M., Keltner Z., Bandele O., Ferguson M., Nemser S., Tkachenko A., Evans E., Crosby T., Woodling K., Loukotková L., and Gamboa da Costa G.
Food Chem Toxicol. 2012, 50(12):4389-97.

Urinary Biomarker Detection of Melamine and Cyanuric Acid-Induced Kidney Injury in Rats.
Zhang Q., Gamboa da Costa G., Von Tungeln L., Jacob C., Brown R., and Goering P.
Toxicol Sci. 2012, 129(1):1-8.

Dose-Response Assessment of Nephrotoxicity from a Twenty-Eight-Day Combined-Exposure to Melamine and Cyanuric Acid in F344 Rats.
Gamboa da Costa G., Jacob C., Von Tungeln L., Hasbrouck N., Olson G., Hattan D., Reimschuessel R., and Beland F.
T Toxicol Sci. 2012, 126(2):317-24.

Pharmacokinetics of Melamine and Cyanuric Acid and their Combinations in F344 Rats.
Jacob C., Von Tungeln L., Vanlandingham M., Beland F., and Gamboa da Costa G.
Toxicol Sci. 2012, 126(2):317-24.

 

Lab Members

Contact information for all lab members:
(870) 543-7121
NCTRResearch@fda.hhs.gov

Suresh K. Nagumalli, Ph.D.
Visiting Scientist (DBT)

Kellie A. Woodling, Ph.D.
Chemist (DBT)

Contact Information
Gonçalo Gamboa da Costa
(870) 543-7121
Expertise
Expertise
Approach
Domain
Technology & Discipline
Toxicology
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