U.S. flag An official website of the United States government
  1. Home
  2. About FDA
  3. FDA Organization
  4. Office of the Commissioner
  5. Office of the Chief Scientist
  6. National Center for Toxicological Research
  7. Science & Research (NCTR)
  8. Amy Inselman
  1. Science & Research (NCTR)

Amy Inselman Ph.D.

Staff Fellow — Division of Systems Biology

Dr. Amy Inselman
Amy Inselman, Ph.D.

(870) 543-7391
NCTRResearch@fda.hhs.gov  

Back to NCTR Principal Investigators page


About  |  Publications  |  Lab Members


Background

Dr. Amy Inselman received her Ph.D. from the University of Tennessee and completed postdoctoral training at the National Institute for Environmental Health Sciences (NIEHS). Her research has focused on reproductive and developmental biology, with a primary emphasis on male reproduction. She is currently a staff fellow at NCTR and has served as the principal investigator on International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) developmental and reproductive guideline studies for the NIEHS/National Toxicology Program.

Research Interests

Dr. Inselman’s current research interests are focused on the investigation and characterization of in vitro models (i.e. stem cells) that may serve as alternatives to whole-animal studies for predicting developmental toxicity. She established the mouse embryonic stem cell test (mEST) within FDA and investigated whether additional differentiation endpoints (e.g. osteoblasts) improves the predictive nature of the assay. Her present work is focused on using human-induced pluripotent stem cells (hiPSCs) to investigate the effects of early opioid exposure on neural development. 

Professional Societies/National and International Groups

Society of Toxicology
Member
2012 – Present

South Central Chapter of the Society of Toxicology (SCCSOT)
Member
2012 – Present

Stem Cell Specialty Section of the Society for Toxicology
Member
2012 – Present

Teratology Society
Member
2012 – Present

Education Committee
2014 – Present

BACK TO TOP

Selected Publications

Disrupting Cyclin Dependent Kinase 1 in Spermatocytes Causes Late Meiotic Arrest and Infertility in Mice.
Clement T.M.*, Inselman A.L.*, Goulding E.H., Willis W.D., and Eddy E.M.
Biol Reprod. 2015, 93(6):137.
*indicates equal contribution by authors

Developing Osteoblasts as an Endpoint for the Mouse Embryonic Stem Cell Test.
Chen X., Hansen D.K., Merry G., DeJarnette C., Nolen G., Sloper D., Fisher J.E., Harrouk W., Tassinari M.S., and Inselman A.L.
Reprod Toxicol. 2015, 53:131-40.

Effects of Silver Nanoparticles on Human and Rat Embryonic Neural Stem Cells.
Liu F., Mahmood M., Xu Y., Watanabe F., Biris A.S., Hansen D.K., Inselman A., Casciano D., Patterson T.A., Paule M.G., Slikker W. Jr., and Wang C.
Front Neurosci. 2015, 9:115.

Effects of Maternal and Lactational Exposure to 2-Hydroxy-4-Methoxybenzone on Development and Reproductive Organs in Male and Female Rat Offspring.
Nakamura N., Inselman A.L., White G.A., Chang C.W., Trbojevich R.A., Sephr E., Voris K.L., Patton R.E., Bryant M.S., Harrouk W., McIntyre B.S., Foster P.M., and Hansen D.K.
Birth Defects Res B Dev Reprod Toxicol. 2015, 104(1):35-51.

Reevaluation of the Embryonic Stem Cell Test.disclaimer icon
Inselman A.L., Nolen G.T., Chang C.W., Harrouk W., Fisher J.E., Tassinari M.S., and Hansen D.K.
Journal of Regulatory Science. 2013, 1(1):32-49.

Alternative Models in Developmental Toxicology.
Lee H.Y., Inselman A.L., Kanungo J., and Hansen D.K.
Syst Biol Reprod Med. 2012, 58(1):10-22.

Assessment of Research Models for Testing Gene-Environment Interactions.
Inselman A.L., Hansen D.K., Lee H.Y., Nakamura N., Ning B., Monteiro J.P., Varma V., and Kaput J.
Eur J Pharmacol. 2011, 668 Suppl 1:S108-16.

Heat Shock Protein 2 Promoter Drives Cre Expression in Spermatocytes of Transgenic Mice.
Inselman A.L., Nakamura N., Brown P.R., Willis W.D., Goulding E.H., and Eddy E.M.
Genesis. 2010, 48(2):114-20.

A Missense Mutation in the Capza3 Gene and Disruption of F-Actin Organization in Spermatids of Repro32 Infertile Male Mice.
Geyer C.B., Inselman A.L., Sunman J.A., Bornstein S., Handel M.A., and Eddy E.M.
Dev Biol. 2009, 330(1):142-52.

BACK TO TOP

Lab Members

Contact information for all lab members:
(870) 543-7391
NCTRResearch@fda.hhs.gov  

Gwenn Merry, M.S.
Biologist

Daniel Sloper, M.S.
Biologist

BACK TO TOP


Contact Information
Amy Inselman
(870) 543-7391
Back to Top