Current Highlight from April 28, 2017
Evaluating Toxicity of Tobacco Smoke Solutions in an In Vitro Air-Liquid-Interface Airway Model
Scientists from FDA’s National Center for Toxicological Research and Center for Tobacco Products have developed an in vitro toxicity testing system. The system consists of an air-liquid-interface (ALI) human-airway tissue model and a panel of toxicity endpoints associated with human respiratory diseases. The ALI culture system was used to evaluate the toxicity of whole smoke solutions (WSSs) prepared from two commercial cigarettes that differ in smoke constituents and showed time- and dose-dependent differences in mucin secretion, matrix metalloproteinase secretion, and protein carbonylation between the two WSSs. Overall, these preliminary results suggest that using human ALI airway models to quantify disease-relevant endpoints is a potential tool for generating toxicity data that may inform tobacco regulatory activities. This study was funded by the FDA Center for Tobacco Products. A manuscript describing the study is available online at Toxicological Sciences.
For more information, please contact Xuefei Cao, Ph.D., Division of Genetic and Molecular Toxicology, FDA/NCTR.
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