Linge (Emily)
Li
PhD.
Leadership Role
Division of Residue Chemistry
Biography
Dr. Linge (Emily) Li is a Research Chemist in the Office of Applied Science at FDA’s Center for Veterinary Medicine. She started her FDA career within Division of Applied Veterinary Research since 2017, then joined Division of Residue Chemistry since 2023. Prior to her federal position, she had worked as a Research Scientist at Pharmaceutical Product Development (PPD), one of the top GLP Contract Research Organizations for more than twelve years. She received her Ph.D in Analytical Chemistry from Loyola University Chicago in 2003, M.S. in Analytical Chemistry from Chinese Academy of Sciences in 1993, and B.S. in Analytical Chemistry from Hunan University, China in 1990. Her primary responsibilities at CVM include conducting and coordinating research in analytical method development and validation using liquid chromatography and tandem mass spectrometry (LC-MS/MS) for veterinary drug pharmacokinetics, tissue depletion, bioequivalence study, residue analysis and regulatory bridging study in food-producing and companion animals.
Research
- Sensitive and robust LC-MS/MS analytical method development and validation in complex biological matrices such as bovine/poultry tissues and plasma.
- Pharmacokinetics, tissue depletion, bioequivalence study, residue analysis and regulatory bridging study.
- Quantitation and confirmation analysis of veterinary drug residue in food-producing animal products.
Select Publications
Linge Li, Karyn Howard, Michael Myers, “Repeated Analysis including Incurred Sample Re-assay (ISR) for Ivermectin and Praziquantel Bioequivalence (BE) Study using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)” (2024), 72nd ASMS, Anaheim, CA.
Linge Li, "Repeat Analysis and Incurred Sample Reanalysis (ISR) for Bioequivalence (BE) Study"(2023), FDA/CVM/OAS Seminar Series.
Linge Li, Karyn Howard, Christine Kilonzo, Michael Myers, “A Quantitative Method to Detect Penicillin G in Limited Amounts of Bovine Tissues using Liquid Chromatography and Tandem Mass Spectrometry (LC-MS/MS)” (2019), 67th ASMS, Atlanta, GA.
Linge Li, "Bioanalytical Method Development and Validation for Penicillin G in Bovine Plasma and Tissues using Liquid Chromatography and Tandem Mass Spectrometry (LC-MS/MS)" (2019), FDA/CVM/OAS Seminar Series.
Marilyn Martines, Raafat Fahmy, Linge Li et al “The Use of Systemically Absorbed Drugs to Explore an In Vitro Bioequivalence Approach for Comparing Non-Systemically Absorbed Active Pharmaceutical Ingredients in Drug Products for Use in Dogs”, in the process of editorial review for the journal of “Pharmaceutical Research”. (2024)
Marc De Meulder, M.P. Waldron, Linge Li, M.G. Peay, M.J. Tingler, B.J. Hidy, T. Verhaeghe, R. G. Jenkins; “Development and Validation of HILIC-ESI/MS/MS Methods for Simultaneous Quantitation of Several Antipsychotics in Human Plasma and Blood”, (2016), Bioanlaysis, 8(8), 765-794.
Linge Li, M.P. Chiarelli, etc. “Product Ion Studies of Diastereomeric Benzo[ghi]fluoranthene-2’-deoxynucleoside Adducts by Electrospray Ionization and Quadrupole Ion Trap Mass Spectrometry” (2006), Analytica Chimica Acta, 557, 191-197.
Linge Li, M.P. Chiarelli, etc. “Differentiation of Isomeric Alkylaniline Adducts of Guanine by ESI Tandem Quadrupole Ion Trap Mass Spectrometry” (2003), Journal of ASMS, 12, 1488-1492.
Linge Li, Y. Guan, “Standard Kovats Indices of Twenty Pesticides and Their Identification in Temp. Programmed Capillary GC” (1995), Chinese J. of Analytical Chem., 23(1), 14-19.
Y. Guan, Linge Li, L. Zhou, “Factor Affecting the Reproducibility and Reliability of Retention Simulation in any Form of Temperature Programmed Capillary GC” (1995), Journal of Separation Science, Vol. 18, Issue 9, 593-596.