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Daniel A. Tadesse DVM, PhD.

Daniel A. Tadesse, DVM, PhD
Daniel A. Tadesse DVM, PhD.

Division of Emerging Technologies


Dr. Daniel Tadesse is a research microbiologist in the Division of Emerging Technologies at the Office of Applied Science. He received his Doctor of Veterinary Medicine (DVM) degree from Addis Ababa University, Ethiopia in 2000 and his PhD from the Ohio State University in 2009. His work is focused on understanding the effect of antimicrobial selective pressure on microbiome and resistomes, and application of metagenomics approach for cataloguing the full complement of resistance genes along the ‘farm to fork’ continuum to facilitate public health management decisions aimed at reducing the source and exposure routes of antimicrobial resistance to humans.


  • Studying the effect of antimicrobials on gut microbiota and its subsequent effect on shaping the reservoirs of antibiotic resistance genes (resistomes) accessible to pathogens along the ‘farm to fork’ continuum.
  • Metagenomics approach for One Health resistance monitoring. 
  • Mapping the microbiomes and resistomes of food animals and animal products.
  • Leveraging organ-on-a-chip technology as an alternative to animal testing to study host drug microbiome interaction.

Select Publications

Feldgarden M, Brover V, Haft DH, Prasad AB, Slotta DJ, Tolstoy I, Tyson GH, Zhao S, Hsu CH, McDermott PF, Tadesse DA, Morales C, Simmons M, Tillman G, Wasilenko J, Folster JP, Klimke W. Validating the NCBI AMRFinder Tool and Resistance Gene Database Using Antimicrobial Resistance Genotype-Phenotype Correlations in a Collection of NARMS Isolates. Antimicrob Agents Chemother. 2019 Aug 19. pii: AAC.00483-19. doi: 10.1128/AAC.00483-19.

Tadesse DA, Li C, Mukherjee S, Hsu CH, Bodeis Jones S, Gaines SA, Kabera C, Loneragan GH, Torrence M, Harhay DM, McDermott PF, Zhao S. Whole-Genome Sequence Analysis of CTX-M Containing Escherichia coli Isolates from Retail Meats and Cattle in the United States. Microb Drug Resist. 2018 Sep;24(7):939-948.

Tadesse DA, Singh A, Zhao S, Bartholomew M, Womack N, Ayers S, Fields PI, McDermott PF. Antimicrobial resistance in Salmonella in the United States from 1948 to 1995. Antimicrob Agents Chemother. 2016 Mar 25; 60(4):2567–71.

Tyson GH, McDermott PF, Li C, Chen Y, Tadesse DA, Mukherjee S, Bodeis-Jones S, Kabera C, Gaines SA, Loneragan GH, Edrington TS, Torrence M, Harhay DM, Zhao S. WGS accurately predicts antimicrobial resistance in Escherichia coli. J Antimicrob Chemother. 2015 Oct; 70(10):2763–9.

Tadesse DA, Bahnson PB, Funk JA, Morrow WEM, Abley MJ, Artuso-Ponte VC, Thakur S, Wittum T, DeGraves FJ, Rajala-Schultz PJ, Gebreyes WA. Yersinia enterocolitica of porcine origin: Carriage of virulence genes and genotypic diversity. Foodborne Pathog Dis. 2013 Jan; 10(1):80–6.

Tadesse DA, Zhao S, Tong E, Ayers S, Singh A, Bartholomew MJ, McDermott PF. Antimicrobial drug resistance in Escherichia coli from humans and food animals, USA, 1950–2000. Emerg Infect Dis. 2012 May; 18(5):741–9.

Contact Information
Daniel A. Tadesse
+1 (240) 402 5474
+1 (301) 210 4685
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