Near-infrared Fluorescence Imaging: A Tool for Enhancing Visualization of Biological Structures
March 7, 2018
- March 7, 2018
- Organized By:
University of Maryland CERSI
Wednesday, March 7, 2018
Yu Chen, PhD
Fischell Department of Bioengineering
University of Maryland
About the Presentation
Near-infrared fluorescence (NIRF) imaging using exogenous contrast agents such as indocyanine green has gained much attention as a tool for enhancing visualization of vasculature and other biological structures during surgical procedures. Innovative molecular imaging techniques based on NIRF imaging are also in the clinical translation pipeline.
In order to address the emerging need for standardization of these technologies, it is necessary to develop and validate test methods suitable for objective, quantitative assessment of device performance. Towards this goal, Dr. Chen and his colleagues at FDA identified a series of phantom-based test methods for characterization of NIRF image quality, including 3D-printed biomimetic phantoms.
Dr. Chen has developed Fluorescence Laminar Optical Tomography (FLOT) to perform depth-resolved quantitative NIRF imaging. Biomedical applications of FLOT include tissue engineering, neuroscience, and oncology. Dr. Chen has utilized FLOT to investigate cell viability, migration, and bone mineralization within bone tissue engineering scaffolds. This technology allows depth-resolved molecular characterization of engineered tissues in 3D. He also investigated the feasibility of FLOT to monitor drug distribution and therapeutic effects during and after photo-immunotherapy (PIT) and to evaluate optimization of the PIT regimen and elucidate its mechanism.
In this lecture, Dr. Chen discussed the NIRF and FLOT imaging techniques and their applications.
About the Presenter
Dr. Yu Chen received his BS in Physics from Peking University in 1997 and his PhD in Bioengineering from the University of Pennsylvania in 2003. From 2003-2007, he pursued his postdoctoral training at MIT.
Dr. Chen became an Assistant Professor of the Fischell Department of Bioengineering at the University of Maryland in College Park in 2007 and has been an Associate Professor since 2014. He served as the Associate Chair and Director of Graduate Program in 2016. He received the Teaching Excellence Award from the Fischell Department of Bioengineering of the University of Maryland in 2011, and the National Science Foundation (NSF) CAREER Award in 2012.
Dr. Chen has published a book, 16 book chapters, and 86 peer-reviewed journal publications. He has been an associate editor of Medical Physics, a guest editor of IEEE Journal of Selected Topics on Quantum Electronics, Journal of Innovative Optical Health Sciences, Neurophotonics, and an Editorial Board member of Scientific Reports. He is a member of IEEE, SPIE, and the Optical Society of America (OSA). He has served as a scientific committee co-chair of Annual World Congress of the Society of Brain Mapping and Therapeutics (SBMT).
Please contact Amal Manseur at Amal.Manseur@fda.hhs.gov.