Webcast | Virtual
Event Title
Biomarkers and Therapeutics for Women's Cardiovascular Health
November 14, 2024
- Date:
- November 14, 2024
University of Maryland CERSI
Thursday, November 14, 2024
3:00 – 4:00 PM (Eastern Standard Time)
Presented By
Alisa Clyne, PhD
Professor
Department of Bioengineering
University of Maryland
About the Presentation
Cardiovascular disease (CVD) is the leading cause of death globally, killing more than 17.9 million people each year. In the U.S., CVD kills more women than all forms of cancer combined, and there are profound sex differences in CVD incidence, progression, and response to treatment. In coronary artery disease, women present with the disease about 10 years later than men. The risk of myocardial infarction is similar in women with a systolic blood pressure between 110-119 mmHg and men with a systolic blood pressure above 160 mmHg. Women have cell-rich stable atherosclerotic plaques as opposed to the lipid-rich unstable plaques that are prevalent in men. And women have higher peri-operative mortality after coronary artery bypass grafting and increased adverse side effects of cardiovascular drugs such as statins, leading to more women stopping statin therapy. Despite these known sex differences, the underlying mechanisms by which CVD differs in men and women remain largely unknown, and the engineering approaches, tools, and technologies necessary to reveal these mechanisms are under-developed. In this talk, I will describe our efforts to study sex differences in CVD using sex-inclusive in vitro, in vivo, and in silico experimental systems to drive basic research and translational advances in women’s heart health.
About the Presenter
Dr. Alisa Morss Clyne is currently a Professor in the Fischell Department of Bioengineering at the University of Maryland. Prior to joining the University of Maryland in January 2019, she was a professor of Mechanical Engineering at Drexel University in Philadelphia, PA for 12 years. Dr. Clyne is director of the Vascular Kinetics Laboratory, which investigates integrated mechanical and biochemical interactions among cells and proteins of the cardiovascular system. She is particularly interested in the integrated effects of blood flow and blood metabolites on vascular diseases ranging from atherosclerosis to Alzheimer’s disease to cancer.
Dr. Clyne received her bachelor’s degree in Mechanical Engineering from Stanford University in 1996. She worked as an engineer in the GE Aircraft Engines Technical Leadership Program for four years, concurrently earning her master’s degree in Mechanical Engineering from the University of Cincinnati. In 2006, she received her Doctorate in Medical and Mechanical Engineering from the Harvard-MIT Division of Health Sciences and Technology. In 2014, she completed the Executive Leadership in Academic Technology and Engineering (ELATE) program.
Dr. Clyne received the NSF CAREER award in 2008, an AHA National Scientist Development Grant in 2010, and the BMES-CMBE Rising Star award in 2011. She received research and educational funding from NSF, NIH, and the AHA among others, and she has published more than 65 peer-reviewed publications in leading journals. She is a fellow of the American Society of Mechanical Engineers, the American Heart Association, the American Institute for Medical and Biological Engineering, and the Biomedical Engineering Society. Her teaching focuses on engineering applications in biological systems, and she founded several programs to enhance diversity within engineering.
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