Submitted 75-Day Premarket Notifications for New Dietary Ingredients
The spreadsheet available for download from this page contains a list of publicly displayable New Dietary Ingredient Notifications (NDINs) that we have reviewed to date. For each NDIN, there is a link to information at http://www.regulations.gov relevant to that notification. The notifications are organized by the NDIN number and are sortable and searchable by:
- NDIN number;
- ingredient name;
- name of the party that submitted the notification;
- date of submission;
- and date of FDA’s response.
The information for each NDIN that is available using this website is the same information that is available through FDA’s Division of Dockets Management (Dockets) and at Regulations.gov. However, some of these notifications contain copyrighted material that can only be obtained through a Freedom of Information (FOI) request or viewed in person at the Dockets Public Reading Room. Please see FDA’s FOI website for more information on how to view materials in person or to submit a FOI request.
Note: Any entries without an active link are in the process of being posted on Regulations.gov. Please check back for updates.
Download List of NDINs
1995 to the Present
in XLSX, 184 KB / in PDF, 1.3 MB
Recent Updates to the List of NDINs
For your convenience, the following are entries that have recently been updated.
| New Dietary Ingredient Notification # | Name of New Dietary Ingredient | Firm | Date of Submission | Date of FDA's Response |
|---|---|---|---|---|
| 1386 | SHCog® | Suheung Co. Ltd. | 3/3/2025 | 5/9/2025 |
| 1389 | Purified Terminalia chebula extract (Y100N) | Yuva Biosciences, Inc. | 3/21/2025 | 5/29/2025 |
| 1390 | Cheezheng Willow tea leaves (Liucha) | Gansu Cheezheng Industrial Group Co., Ltd. | 3/27/2025 | 6/5/2025 |
| 1394 | Vernonanthura nudiflora extract | O Sigma Cell and Genetics LLC | 4/4/2025 | 6/11/2025 |
| 1395 | Ora-pro-nobis | MKbio USA | 4/11/2025 | 5/7/2025 |
| 1396 | Saccharomyces cerevisiae S288C EV1-Peptide | BioDrive, Inc. | 4/28/2025 | 7/3/2025 |
| 1397 | ALH-L1005 | AngioLab, Inc. | 4/15/2025 | 6/26/2025 |
| 1398 | Astaxanthin-rich carotenoid fermentation product | LCY Biosciences, Inc. | 5/20/2025 | 7/28/2025 |
| 1399 | Yeast powder IT | INTAKE Co.,Ltd | 4/25/2025 | 6/4/2025 |
| 1400 | Leanepic Rosemary Concentrate containing 50% ursolic acid | CJ CheilJedang Corporation | 4/30/2025 | 7/9/2025 |
| 1401 | Weissella cibaria JW15 | Huons Foodience Co., Ltd. | 4/30/2025 | 7/9/25 |
| 1402 | Lacticaseibacillus paracasei subsp. paracasei (or L. paracasei) strain HY7017 | hy Co., Ltd. | 5/6/2025 | 7/17/25 |
| 1403 | Galangal Extract | TCI Co., Ltd | 5/14/2025 | 7/22/25 |
| 1404 | Lactiplantibacillus plantarum Strain CNCM I-6042 | Société des Produits Nestlé S.A. | 5/19/2025 | 7/25/25 |
| 1406 | Monomethylsilanetriol stabilized in hydrolyzed fish collagen | USK | 5/23/2025 | 7/3/25 |
| 1407 | Heat-treated culture of Bifidobacterium longum CBi0703 | BIOSE INDUSTRIE | 5/27/2025 | 7/28/25 |
| 1408 | AEDG Peptide | Amritex Inc. | 5/28/2025 | 7/3/25 |
| 1409 | Mangosteen Peel Extract | Fytexia | 6/2/2025 | 8/7/25 |
| 1410 | EmmerWheat | KMF Co., Ltd. | 6/13/2025 | 7/16/25 |
| 1411 | Tamarind Seed Polysaccharide | DEVINTEC SAGL | 6/13/2025 | 8/12/25 |
| 1412 | Porcine kidney protein extract with Diamine Oxidase (DAO) | Body Nostrum LLC | 6/16/2025 | 7/29/25 |
| 1413 | Diosmin / Micronized Diosmin | Bordas S.A. | 6/23/2025 | 8/28/25 |
| 1414 | Latilactobacillus curvatus LB-P9 | LISCure Biosciences Inc. | 6/27/2025 | 9/3/25 |
| 1415 | T-ChOS (proprietary name by Genis hf.) | Genis hf. | 6/30/2025 | 9/10/25 |
| 1416 | Benesomno™ | Nutra-it Inc. | 6/30/2025 | 9/9/25 |
| 1417 | Amanita muscaria mushroom extract (AME-1) | Psyched Wellness | 7/8/2025 | 9/18/25 |
| 1418 | Concentrated Nutriterra® Omega-3 | Nuseed Nutritional US Inc. | 7/10/2025 | 9/19/25 |
| 1419 | Vernonanthura nudiflora extract | OSigma Cell & Genetics | 7/10/2025 | 9/19/2025 |
| 1420 | β-Nicotinamide Riboside Citrate | Shenzhen Nuojiayi Technology CO.,Ltd | 7/11/2025 | 9/23/2025 |
| 1421 | Jatropha macrantha (commonly known as Huanarpo Macho) Powder | Toro Naturals LLC | 7/14/2025 | 9/22/2025 |
| 1422 | Heri-Mycelium HE12 | NEW BELLUS ENTERPRISES CO., LTD | 7/18/2025 | 9/26/2025 |
| 1423 | Lactobacillus farraginis | epikur international AG | 7/18/2025 | 9/25/2025 |
| 1424 | Muno-IgY | IGY Immune Technologies and Life Sciences, Inc. | 7/23/2025 | 9/26/2025 |
| 1425 | Cannabis Sativa L. Essential Oil | Mondays Foods, LLC | 9/8/2025 | 11/21/2025 |
| 1426 | NP-14D | Dave's Tinctures | 7/29/2025 | 11/28/2025 |
| 1427 | CHAGADVANCE™ Chaga extract | SEPPIC S.A. | 7/29/2025 | 9/30/2025 |
| 1428 | Astragalus extract mixture (HT042) aka Grow HT042 | NEUMED, Inc. | 7/30/2025 | 9/30/2025 |
| 1429 | Cell-wall Broken Ganoderma Lucidum Spore Powder | Fujian Xianzhilou Biological Science and Technology Co., Ltd. | 7/31/2025 | 9/30/2025 |
| 1430 | Spirulysat | ALGOSOURCE | 8/4/2025 | 12/5/2025 |
| 1431 | First Phytoplankton® | Phytoplankton Solutions Inc. | 8/5/2025 | 12/4/2025 |
| 1432 | Bovine Gelatin Tannate powder | California Greens | 8/12/2025 | 11/28/2025 |
| 1433 | Phaeodactylum tricornutum extract powder | Microalgae Ask Us | 8/13/2025 | 12/3/2025 |
| 1434 | Calcium L-5-Methyltetrahydrofolate (L-5-MTHF-Ca) | Wuxi Taxus Pharmaceutical Co., Ltd. | 8/15/2025 | 12/5/2025 |
| 1435 | IMG-1 | Imagin Pharma | 8/25/2025 | 12/18/2025 |