U.S. flag An official website of the United States government
  1. Home
  2. Drugs
  3. Drug Safety and Availability
  4. Safe Use Initiative
  5. Real-time Risk Stratification for Hypo- or Hyperglycemia to Enhance Glucose Management Outcomes in Hospitals
  1. Drug Safety and Availability

Real-time Risk Stratification for Hypo- or Hyperglycemia to Enhance Glucose Management Outcomes in Hospitals

Real-time Risk Stratification for Hypo- or Hyperglycemia to Enhance Glucose Management Outcomes in Hospitals

Performer: University of Florida
Principal Investigator:
Almut Winterstein, PhD

Project Duration: 9/30/15-9/29/17

Regulatory Science Challenge

Antihyperglycemic agents have been included as one of the three important drug classes in a national action plan to reduce preventable adverse drug events. While hypoglycemia has been recognized as one of the national patient safety priorities, hyperglycemia has also been associated with negative outcomes for hospitalized patients, including increases in infection and mortality rates. The research group at the University of Florida recently developed two prediction algorithms for hypo- and hyperglycemia in hospitalized patients, which have demonstrated excellent predictive performance in the two largest hospitals affiliated with the University of Florida (UF Shands and UF Jacksonville). The feasibility and effectiveness of the prediction algorithms in reducing hypo- and hyperglycemia rates need to be evaluated.

Project Description

The University of Florida research team will conduct this study at UF Shands and UF Jacksonville. The two prediction algorithms will run fully automated in the electronic health records (EHR) to generate morning reports of patients ranked according to their risks for hypo- and hyperglycemia. The patient rankings will be integrated in the routine work queue of clinical pharmacists, who will be expected to follow up on all high-risk patients and to document their interventions for all patients in the 90th risk score percentile. The effectiveness of the prediction algorithms will be evaluated based on changes in hypo- and hyperglycemia rates.

Project Goals

  • Implement the hypo- and hyperglycemia prediction algorithms in the EHR at UF Shands and UF Jacksonville, for automated retrieval of risk factors and generation of patient scores
  • Present the risk scores to clinical pharmacists to guide interventions
  • Evaluate the effectiveness of the algorithms in reducing hypo- and hyperglycemia rates