Why Are There So Many ADRs?
Schappert SM. Nat. Center Health Statistics. 1999, Series 13 No. 143
National Association of Chain Drug Stores. 2001
Jacubeit T et al. Agents Actions Suppl 1990;29:117–125
Two-thirds of patient visits result in a prescription
2.8 BILLION outpatient prescriptions (10 per person in the United States) filled in 2000
ADRs increase exponentially with 4 or more medications