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  1. Drug Interactions & Labeling

Ventricular Arrhythmia (Torsades de Pointes) Occurring in Association with Terfenadine Use

Monahan BP et al. JAMA 1990;264:2788–2790
  • 39 y.o. female with 2-day Hx of intermittent syncope
  • Rx with terfenadine 60 mg bid and cefaclor 250 mg tid ? 10 d
  • Self-medicated with ketoconazole 200 mg bid for vaginal candidiasis
  • Palpitations, syncope, torsades de pointes (QTc 655 msec)

 

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