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  1. Drug Interactions & Labeling

This slide demonstrates the effects of grapefruit juice on felodipine pharmacokinetics and pharma-codynamics.1 The left graph shows felodipine plasma concentrations at specific time points, up to 24 hours, following administration of a single dose of felodipine with 250 cc of grapefruit juice or water. The right graph shows systolic and diastolic blood pressure from the same time points. Compared with water, there is an increase in felodipine plasma concentrations, as well as a decrease in systolic and diastolic blood pressure. This demonstrates a potentially clinically significant effect of the grapefruit juice-felodipine interaction.

Dresser GK et al Clin Pharmacol Ther 2000;68(1):28–34


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