U.S. flag An official website of the United States government

On Oct. 1, 2024, the FDA began implementing a reorganization impacting many parts of the agency. We are in the process of updating FDA.gov content to reflect these changes.

U.S. Food and Drug Administration
  1. Home
  2. Drugs
  3. Development & Approval Process | Drugs
  4. Development Resources
  5. Drug Interactions & Labeling
  6. Cytochrome P450 2D6
  1. Drug Interactions & Labeling

Cytochrome P450 2D6

Aklillu E et al. J Pharmacol Exp Ther 1996;278(1):441– 446
  • Absent in 7% of Caucasians, 1–2% non-Caucasians
  • Hyperactive in up to 30% of East Africans
  • Catalyzes primary metabolism of:
    • Codeine
    • Many ?-blockers
    • Many tricyclic antidepressants
  • Inhibited by:
    • Fluoxetine
    • Haloperidol
    • Paroxetine
    • Quinidine

 

Back to Learning Module

Back to Top