Cytochrome P450 2D6
Aklillu E et al. J Pharmacol Exp Ther 1996;278(1):441– 446
Absent in 7% of Caucasians, 1–2% non-Caucasians
Hyperactive in up to 30% of East Africans
Catalyzes primary metabolism of:
- Codeine
- Many ?-blockers
- Many tricyclic antidepressants
Inhibited by:
- Fluoxetine
- Haloperidol
- Paroxetine
- Quinidine