Cytochrome P450 2C9
Absent in 1% Caucasians and African-Americans
Primary metabolism of:
Most NSAIDs (including COX-2)
S-warfarin (the active form)
Phenytoin
Inhibited by:
Fluconazole
Most NSAIDs (including COX-2)
S-warfarin (the active form)
Phenytoin
Fluconazole