Drug Establishments Current Registration Site (DECRS)
Search the Drug Establishments Current Registration Site Database
The Drug Establishments Current Registration Site (DECRS) is a publication of currently registered establishments which manufacture, prepare, propagate, compound or process drugs that are distributed in the U.S. or marketed for import to the U.S.
This file is updated each business day. An establishment is automatically removed from the database:
- If its registration is inactivated by FDA due to a compliance case or other enforcement action
- If its registration has expired, been deregistered or is otherwise dropped from submission
Establishments must be registered within five days of beginning operations. Additionally, establishments must renew registration annually between October 1 and December 31 of each year.
Establishments that send initial or annual registrations during the October 1 to December 31 period are considered registered until the end of following calendar year. Any registration submission received outside of this timeframe does not extend the registration expiration date beyond the current calendar year.
Examples:
- A new, updated or annual establishment registration structured product labeling (SPL) is received on October 1, 2025. Registration is current through December 31, 2026.
- A new or updated registration SPL or no change notification document is received on September 30, 2025. Registration is current through December 31, 2025. An updated establishment registration or a no change notification document must be submitted between October 1, 2025, and December 31, 2025, to remain current through December 31, 2026.
Download and search
- Drug establishment registration search
- Drug establishment annual registration status download file (zip format)
- Drug establishment annual registration status (Excluded) download file (zip format) (New)
About the registration database
- This database does not contain establishments registered as human drug compounding outsourcing facilities
- An outsourcing facility may appear in the database if it also registered under other business operations
- This database does not contain wholesale drug distributors and third-party logistics providers that report licensure annually to the FDA as required by the Drug Supply Chain Security Act
- Visit wholesale distributor and third party logistics providers reporting for more information. Contact WDD3PLRequirements@fda.hhs.gov with questions about wholesale drug distributors and third-party logistics providers.
Questions
Contact eDRLS@fda.hhs.gov with questions on establishment registration and drug listing requirements. See points of contact for establishment registration and drug listing for more information.