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  1. Development & Approval Process

Drugs with Veterinary Feed Directive (VFD) Marketing Status

This list represents the medically important antimicrobials approved for use in or on animal feed that require a VFD, including those that transitioned from over-the-counter (OTC) to VFD marketing status upon completion of the implementation of Guidance for Industry (GFI) #213.

Please note that as a result of the implementation of GFI #213, approvals for penicillin alone or penicillin in fixed combination with chlortetracycline/sulfamethazine for use in animal feed have been voluntarily withdrawn. Additionally, the approval for oleandomycin was voluntarily withdrawn in 2017.

All feed uses of the following drugs, alone and in a combination with another drug(s), require a VFD:

Drugs that require a VFD

Established drug name
apramycin
avilamycin1
chlortetracycline (CTC)
chlortetracycline/sulfamethazine2
erythromycin
florfenicol1
hygromycin B
lincomycin
oxytetracycline/neomycin2
sulfadimethoxine/ormetoprim2
sulfamerazine
sulfaquinoxaline
tilmicosin1
tylosin
tylosin/sulfamethazine2
tylvalosin1
virginiamycin

1Drug product that has been VFD since its approval, and continues to require a VFD

2Fixed-ratio, combination drug

Note: Some of the VFD drugs on the list above may not be marketed at this time. If you have questions regarding the availability of a VFD drug, contact your local distributor.

This information is up-to-date as of November 1, 2017.

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