FDA Funded Grants and Contracts Related to Antimicrobial Use and Resistance in Animals
The FDA’s Center for Veterinary Medicine funds several projects carried out by state and local health departments, university investigators, and other partners as part of its efforts to generate data related to antimicrobial use, resistance, and stewardship in animals. These activities may be funded through cooperative agreements, grants, or contracts and are listed below by topic and Request for Applications (RFA) identifier. Project funding status and award announcements may change over time, so this page will be regularly updated and is broken into sections by open funding opportunities, ongoing projects, and completed projects.
Open Funding Opportunities
Notice of Funding Opportunity: Cooperative Agreement for Long Term Data Collection on Antimicrobial Use in Animals (RFA-FD-24-031)
Ongoing Projects
In 2024, CVM funded cooperative agreements to collect, analyze, and report data on antimicrobial use in animals. This program supports long term antimicrobial use data collection efforts within the United States. The cooperative agreements provide each recipient with $200,000 for fiscal year (FY) 2024, with the potential for continued funding for up to four additional years contingent upon annual appropriations, availability of funding, and satisfactory recipient performance.
Projects funded in FY2024 include:
Mindwalk Consulting Group (Grant number 1U01FD008419)
- Project Title: Antimicrobial Use Data Collection in the U.S. Poultry Production System
- Additional project details are available through NIH reporter
- Publications: No publications available currently
Cornell University (Grant number 1U01FD008421)
- Project Title: A System Approach to Animal-Level Antimicrobial Use Monitoring in Dairy Cattle
- Additional project details are available through NIH reporter
- Publications: No publications available currently
Kansas State University (Grant number 1U01FD008416)
- Project Title: Bridging Critical Data Gaps in Veterinary Medicine Via Artificial Intelligence and Advanced Large Language Models to Procure Real-Time Antibiotic Use Data in Livestock, Poultry and Companion Animals
- Additional project details are available through NIH reporter
- Publications: No publications available currently
In 2022, CVM awarded a $300,000 grant to fund education and outreach efforts to support antimicrobial stewardship practices in food-producing animals. This project may be funded through 2024.
Michigan State University (Grant number 1U01FD007790)
- Project Title: Combining benchmarking and competency-based training to implement antimicrobial stewardship on dairy farms
- Additional project details are available through NIH Reporter
- Publications: no publications available currently
In 2022, CVM funded a $500,000 cooperative agreement for the collection of information about animal diseases that are the most significant for antimicrobial use in various animal production settings for the four major food-producing species (i.e., cattle, swine, turkeys, and chickens), and to provide information about alternative practices that may help reduce the reliance on such drugs while addressing animal health needs. Such alternatives can include changes in husbandry, biosecurity, vaccination, and other management practices.
This cooperative agreement will provide information to support the continued advancement of initiatives related to supporting antimicrobial stewardship in veterinary settings and will support the National Action Plan objectives to engage the animal health community and relevant stakeholders.
This project may be funded through 2025.
Iowa State University (Grant number 1U01FD007683)
- Project Title: Integration of a multi-pronged standardized methodology to identify key diseases and prioritized antimicrobial alternatives in production animals
- Additional project details are available through NIH Reporter
- Publications: no publications available currently
Since 2020, CVM has funded two $200,000 cooperative agreements for the collection of data on antimicrobial use in dogs and cats. Data collected will support efforts to assess potential associations between antimicrobial use practices in dogs and cats and antimicrobial resistance. Data collected through these projects will support efforts to assess potential associations between antimicrobial use practices in dogs and cats and antimicrobial resistance. These projects have been funded through 2025.
University of Minnesota (Grant number 5U01FD007061)
- Project Title: Representative, scalable, and sustainable surveillance methodologies to track companion animal antimicrobial use
University of Minnesota Antimicrobial Resistance and Stewardship Initiative (ARSI) website - Additional project details are available through NIH Reporter
- Publications:
- Results of antibiotic use studies: Results of Antibiotic Use Studies | Antimicrobial Resistance and Stewardship Initiative (umn.edu)
- 2020 National Veterinary Teaching Hospital Point-Prevalence Survey of Antibiotic Use in Dogs and Cats
- 2020 infographic of results
- Beaudoin AL, Bollig ER, Burgess BA, Cohn LA, Cole SD, Dear JD, Fellman CL, Frey E, Goggs R, Johnston A, Kreuder AJ, KuKanich KS, LeCuyer TE, Menard J, Reagan KL, Sykes JE, Veir JK, Viviano K, Wayne A, Granick JL. Prevalence of antibiotic use for dogs and cats in United States veterinary teaching hospitals, August 2020. J Vet Intern Med. 2023 Sep-Oct;37(5):1864-1875. DOI: 10.1111/jvim.16814.
- 2021 National Primary Care and Referral Hospital Point-Prevalence Survey of Antibiotic Use in Dogs and Cats
- 2022 U.S. and Canadian Veterinary Teaching Hospital Point-Prevalence Survey of Antibiotic Use in Dogs and Cats
- 2023 U.S. Dermatology Referral Practices Antimicrobial Use Study in Dogs and Cats
- 2023 U.S. Dental Referral Practices Antibiotic Use Study in Dogs and Cats
- 2023 infographic of results
- Volk, VC AL, Goldschmidt, SL, Bollig ER, Granick JL. Prophylactic antibiotic use is common in dogs and cats presenting for procedures at veterinary referral dental practices. JAVMA. 2024. DOI: https://doi.org/10.2460/javma.24.08.0524
North Carolina State University (Raleigh) (Grant number 5U01FD007057)
- Project Title: Automated Data Collection on Antimicrobial Use in Dogs and Cats in a Tertiary Hospital and Private Practices
- Additional project details are available through NIH Reporter
- Publications:
- Jolley, A., Love, W., Frey, E., & Lanzas, C. Impacts of the COVID-19 pandemic on antimicrobial use in companion animals in an academic veterinary hospital in North Carolina. Zoonoses and Public Health. 2023; 70, 393– 402. https://doi.org/10.1111/zph.13040
Vet-LIRN Veterinary Diagnostic Laboratory Program (U18): (PAR-22-063)
As part of the National Action Plan, Vet-LIRN was tasked to develop, expand, and maintain antimicrobial susceptibility testing (AST) and whole-genome sequencing (WGS) testing of veterinary pathogens isolated at veterinary diagnostic laboratories. To successfully monitor the antimicrobial susceptibility of bacterial pathogens, it is vital that veterinary diagnostic laboratories be incorporated into the nation’s other surveillance activities. Vet-LIRN is committed to being a partner in such an effort.
As of January 2024, Vet-LIRN labs collected antimicrobial susceptibility data for more than 25,000 animal pathogen isolates and more than 7,500 isolates were sequenced. The data so far provides a snapshot of the susceptibility of pathogens being cultured at referral veterinary laboratories. Vet-LIRN is partnering with the National Antimicrobial Resistance Monitoring System (NARMS) to make the data public (2017-2021 AMR data), with animal pathogen data being reported in conjunction with the National Animal Health Laboratory Network (NAHLN).
Where is this information accessible?
Vet-LIRN makes its animal pathogen antimicrobial resistance data public as part of the annual NARMS Integrated Report and on NCBI.
Interactive map of Vet-LIRN laboratories
Vet-LIRN Network Capacity-Building Project and Equipment Grants (U18) – (PAR-23-202).
This funding opportunity is intended to build domestic laboratory capacity under the Food Safety and Modernization Act (FSMA) and develop Vet-LIRN laboratory capability and capacity to investigate potential animal foodborne illness outbreaks. Vet-LIRN laboratories may apply for funding for research related to emerging public food safety issues identified by Vet-LIRN and for equipment and personnel necessary to expand laboratory capability and capacity. This cooperative agreement also allows the network to perform projects focused on stewardship education and leverage emerging technologies such as whole genome sequencing (WGS), particularly as a part of the Vet-LIRN AMR Program described above.
Vet-LIRN currently has 3 ongoing capacity grants with a focus on antimicrobial stewardship education.
Purdue University (Grant number 1 U18 FD007714)
- Project Title: Competency-based training modules for antimicrobial stewardship and infection prevention in veterinary and veterinary nursing curricula
- Publications: no publications available currently
University of Pennsylvania (Grant number 1 U18 FD008363)
- Project title: A pilot study of veterinary antifungal use and resistance in support of Vet-LIRN's antimicrobial stewardship efforts
- Publications: no publications available currently
North Carolina State University (Grant number 1 U18 FD008350)
- Project title: Impact of antimicrobial stewardship resources on companion animal veterinarians’ intention and capability to prescribe fewer antimicrobial drugs
- Publications: no publications available currently
NARMS boasts coverage of 24 states via 23 partner laboratories from universities, state departments of public health, and departments of agriculture that purchase retail meat and seafood samples and culture them for target bacteria. They submit these isolates to FDA, where scientists may confirm the isolates’ species and serotype, perform antimicrobial susceptibility testing, and conduct genetic analyses using whole genome sequencing on a proportion of the isolates submitted.
Where is this information available?
The NARMS program now routinely performs whole genome sequencing on nearly all sampled isolates and deposits the results into a national pathogen tracking database at the National Institutes of Health, National Center for Biotechnology Information.
Completed Projects
Vet-LIRN has completed 6 capacity grant projects with a variety of publicized stewardship materials.
Kansas State University (Grant number 1 U18 FD006990)
- Project Title: Prototype Reporting and Veterinarian and Animal Owner Educational Materials for Cases of Antimicrobial Resistant Bacteria of Public Health Importance in Companion Animals
- Antibiotic resistant bacteria educational handouts: Information about Antibiotic Resistant Bacteria in Companion Animals (ksvhc.org)
- Publications:
- KuKanich, K., Burklund, A., McGaughey, R., Muturi, N., Thomason, S., Chengappa, M., Garrison, I., Stacey, B., Zhang, S., and Gull, T. One Health Approach for Reporting Veterinary Carbapenem-Resistant Enterobacterales and Other Bacteria of Public Health Concern. Emerging Infectious Diseases. 2023; 29(6), 1-9. https://doi.org/10.3201/eid2906.221648
Cornell University (Grant number 1U18FD006992)
- Project Title: Lab-supported Antimicrobial Stewardship at the Cornell University Hospital for Animals
- Publications: no publications available currently
University of Pennsylvania (Grant number 1 U18 FD006984)
- Project Title: A Multicenter Study to Evaluate Veterinary Students' Confidence and Competence in Antimicrobial Selection
- Carbapenem-Resistant Enterobacterales (CRE) resource website: Penn Vet | CREATE (upenn.edu)
- Publications:
- Cole, S., Burbick, C., Daniels, J., Diaz-Campos, D., Winget, J., Dietrich, J., and LeCuyer, T. A Multicenter Evaluation of a Metacognitive Framework for Antimicrobial Selection Education. Journal of Veterinary Medical Education. 2024. https://doi.org/10.3138/jvme-2023-0163
University of Pennsylvania (Grant number 1 U18 FD007496)
- Project Title: Development of an Educational Video in Support of Vet-LIRN Antimicrobial Stewardship Efforts
- SODAPOP metacognitive framework educational videos: Penn Vet | TOOLS, CORES & LABS (upenn.edu)
- Publications: no publications available currently
The Ohio State University (Grant number 1 U18 FD007232)
- Project Title: Building sequencing capacity to address nosocomial infections in primary care and referral veterinary medical facilities
- Publications: no publications available currently
The Ohio State University (Grant number 1 U18 FD007232)
- Project Title: Facilitating antimicrobial stewardship with an educational video series approach
- Educational videos: Antimicrobial Stewardship Program | College of Veterinary Medicine (osu.edu)
- Publications: no publications available currently
In 2021, CVM asked the Reagan Udall Foundation for the FDA (the Foundation) to seek input from a variety of affected stakeholders about strategies for collecting data regarding antimicrobial use in food-producing animals. This project is an important opportunity to consider strategies for collaboration between the public and private sectors. CVM hopes that through this stakeholder dialogue, it can learn about capabilities and challenges facing the veterinary, agricultural, and public health communities when it comes to collecting and sharing antimicrobial-use data. The Foundation is conducting this outreach under a cooperative agreement with the FDA.
- Additional details are available through the Reagan-Udall Foundation Program Page: Antimicrobial Use Data in Food Animals
- Publications:
- Summary Report: Exploring the Potential for a Public-Private Partnership to Support the Tracking and Monitoring of Antimicrobial Use in Food-Producing Animals
- Summary Report: Establishing a Framework for a Public-Private Partnership to Support the Tracking and Monitoring of Antimicrobial Use in Food-Producing Animals
In 2019, CVM awarded two $250,000 grants in 2019 and one $500,000 grant in 2020 to fund research projects to help target and define durations of use for certain medically important antimicrobial drugs approved for use in the feed of food-producing animals.
Kansas State University (Grant 1U01FD006804)
- Project Title: Defining targeted durations of use for tylosin phosphate to prevent liver abscess formation in feedlot cattle
- Additional project details are available through NIH Reporter
- Publications: no publications available currently
Kansas State University (Grant 5U01FD006803)
- Project Title: Evaluation of chlortetracycline-treatment timing on the duration of treatment of bovine anaplasmosis in adult cattle
- Additional project details are available through NIH Reporter
- Publications: no publications available currently
Texas A&M Agrilife Research (Grant 1U01FD007049)
- Project Title: Evaluating duration of tylosin phosphate treatment in feedlot cattle for liver abscess prevention to ensure efficacy while addressing concerns about antimicrobial resistance
- Additional project details are available through NIH Reporter
- Publications: no publications available currently
Since 2016, CVM previously funded two $300,000 cooperative agreements for antimicrobial use and resistance data collection in food-producing animals. These efforts provided part of the baseline information on antimicrobial use practices in the four major food-producing animal species (cattle, swine, chickens, and turkeys), a critical element in measuring the overall impact of the agency’s judicious use strategy. The data collection efforts provided important information on methodologies to help optimize long-term strategies for collecting and reporting such data.
A summary of information regarding the methodologies, data sources, and metrics from the cooperative agreements is summarized in an article.
Kansas State University (Grant number 5U01FD005868)
- Project Title: Characterization of Antimicrobial Use in Beef Feedlots and Dairies
- Additional project details are available through NIH Reporter
- Publications:
- Schrag, NFD, Godden, SM, Singer, RS, Lombard, JE, Wenz, JR, Amrine, DE, Lubbers, BV, Apley, MD. Improving farm-level antimicrobial stewardship benchmarks by reporting antimicrobial use within the context of both the magnitude of disease pressure and the outcome of therapy. Frontiers in Veterinary Science. 2022; 9: 1022557. https://doi.org/10.3389/fvets.2022.1022557
- Schrag, NFD, Apley, MD, Godden, SM, Lubbers, BV, Singer, RS. Antimicrobial use quantification in adult dairy cows – Part 1 – Standardized regimens as a method for describing antimicrobial use. Zoonoses Public Health. 2020; 67(Suppl. 1): 51– 68. https://doi.org/10.1111/zph.12766
- Schrag, NFD, Apley, MD, Godden, SM, Singer, RS, Lubbers, BV. Antimicrobial use quantification in adult dairy cows – Part 2 – Developing a foundation for pharmacoepidemiology by comparing measurement methods. Zoonoses Public Health. 2020; 67(Suppl. 1): 69– 81. https://doi.org/10.1111/zph.12772
- Schrag, NFD, et al. Antimicrobial use quantification in adult dairy cows – Part 3 – Use measured by standardized regimens and grams on 29 dairies in the United States. Zoonoses Public Health. 2020; 67(Suppl. 1): 82– 93. https://doi.org/10.1111/zph.12773
- Hope, KJ et al. Antimicrobial use in 22 U.S. beef feedyards: 2016–2017. Zoonoses Public Health. 2020; 67(Suppl. 1): 94– 110. https://doi.org/10.1111/zph.12775
- Hope, K.J. et al., Comparison of surveys and use records for quantifying medically important antimicrobial use in 18 U.S. Beef Feedyards. Zoonoses Public Health, 2020. 67(S1): p. 111-123. https://doi.org/10.1111/zph.12778
- Apley MD, Schrag NFD, Amrine DE, Lubbers BV and Singer RS (2023) The association of multiple metrics for evaluating antimicrobial use in U.S. beef feedyards. Front. Vet. Sci. 9:1056476. doi: 10.3389/fvets.2022.1056476
- Apley MD, Schrag NFD, Amrine DE, Lubbers BV, Singer RS. Antimicrobial use in 20 U.S. beef feedyards: 2018-2019. Front Vet Sci. 2023 Mar 27;10:1056362. doi: 10.3389/fvets.2023.1056362.
Mindwalk Consulting Group (Grant number 5U01FD005878)
- Project Title: Antibiotic Use Data Collection in U.S. Poultry and Swine Production [Dashboard]
- Additional project details are available through NIH Reporter
- Publications:
- Davies, PR, Singer, RS. Antimicrobial use in wean to market pigs in the United States assessed via voluntary sharing of proprietary data. Zoonoses Public Health. 2020; 67(Suppl. 1): p. 6-21. https://doi.org/10.1111/zph.12763
- Singer, SS et al., Estimates of on-farm antimicrobial usage in broiler chicken production in the United States, 2013-2017. Zoonoses Public Health, 2020. 67(Suppl. 1): p. 22-35. https://doi.org/10.1111/zph.12764
- Singer, RS et al., Estimates of on-farm antimicrobial usage in turkey production in the United States, 2013–2017. Zoonoses Public Health. 2020; 67(Suppl. 1): p. 36– 50. https://doi.org/10.1111/zph.12763
- Krista D Gens, Randall S Singer, Thomas J Dilworth, Emily L Heil, Amanda L Beaudoin, Antimicrobials in Animal Agriculture in the United States: A Multidisciplinary Overview of Regulation and Utilization to Foster Collaboration: On Behalf Of the Society of Infectious Diseases Pharmacists, Open Forum Infectious Diseases, Volume 9, Issue 11, November 2022, ofac542, https://doi.org/10.1093/ofid/ofac542
- Bueno, I., Ricke, I., Hwang, H., Smith, E., Nault, A., Johnson, T. J., & Singer, R. S. (2023). Efficacy of Antibiotic and Non-antibiotic Interventions in Preventing and Treating Necrotic Enteritis in Broiler Chickens: A Systematic Review. Avian diseases, 67(1), 20–32. https://doi.org/10.1637/aviandiseases-D-22-00069
- Singer RS, Schrag NFD, Ricke I and Apley MD (2023) Antimicrobial usage in broiler chicken production in the United States, 2013–2021. Front. Vet. Sci. 10:1139908. doi: 10.3389/fvets.2023.1139908
- Singer RS, Schrag NFD, Ricke I and Apley MD (2023) On-farm antimicrobial usage in commercial turkey production in the United States, 2013–2021. Front. Vet. Sci. 10:1158943. doi: 10.3389/fvets.2023.1158943
- Singer RS. Estimates of on-farm antimicrobial usage in egg production in the United States, 2016-2021. Front Vet Sci. 2023 Mar 30;10:1135377. doi: 10.3389/fvets.2023.1135377. PMID: 37065233; PMCID: PMC10097876.