AURA3: Skin cracking at corners of your mouth

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In AURA3 Study, Patients Were Asked: "In the last 7 days, what was the SEVERITY of SKIN CRACKING AT CORNERS OF YOUR MOUTH at its WORST?"

Patients scored the severity of their Skin Cracking at Mouth Corners on a 5-point scale (None, Mild, Moderate, Severe, Very Severe)

Patient-Reported Skin Cracking at Mouth Corners During the First 24 Weeks on Treatment for Patients Who Completed a Questionnaire:

Figure 1 shows the percentage of patients reporting the severity of their Skin Cracking at Mouth Corners at each time point. For example, at week 2, 9% of patients taking Tagrisso reported Skin Cracking at Mouth Corners(ranging from Mild to Moderate). The range of patients who had any Skin Cracking at Mouth Corners during the first 24 weeks of treatment with Tagrisso was between 7% - 18%. Click here for more information on how to read the graphs below.

Figure 1. Patient-Reported Skin Cracking at Mouth Corners the First 24 Weeks on Treatment

Two stacked bar charts, one for Tagrisso and the other for chemotherapy, showing proportion of patients reporting the severity of skin cracking at mouth corners at each time point through the first 24 weeks of treatment. For example, at week 2, 9% of patients taking Tagrisso reported skin cracking at mouth corners (ranging from mild to moderate).

All responses from patients' experiences just before and up to week 24 on-treatment were included in the analysis. Some patients did not report their symptoms every week, therefore the number of patients may vary between weeks. Furthermore, not all patients remained on the treatment for 24 weeks (e.g., some stop treatment for worsening disease) which is a reason for the change in the number of patients over the course of treatment.

Worst Response Option for Skin Cracking at Mouth Corners That Patients Reported During the First 24 Weeks on Treatment

Figure 2. Worst Patient-Reported Skin Cracking at Mouth Corners During the First 24 Weeks on Treatment

Two pie charts, one for Tagrisso and the other for chemotherapy, summarizing the percentage of patients by worst reported skin cracking at mouth corners during the first 24 weeks of the clinical trial. In the Tagrisso arm, None (60%), Mild (27%), Moderate (8%), Severe (5%) and Very severe (0%). In the chemotherapy arm, None (51%), Mild (36%), Moderate (9%), Severe (2%) and Very severe (2%).

Patients with at least one on-treatment Skin Cracking at Mouth Corners score were included in the analysis. Tagrisso (N=99), Chemotherapy (N=55).

Some Patients Did Not Report Skin Cracking at Mouth Corners Before Treatment:

For patients that did not report Skin Cracking at Mouth Corners before treatment, Figure 3 shows the percentage of patients reporting the severity of their Skin Cracking at Mouth Corners between weeks 1 and 24.

Figure 3. Patient-Reported Skin Cracking at Mouth Corners During the First 24 Weeks on Treatment: Patients Without Skin Cracking at Mouth Corners Before Treatment

Two stacked bar charts, one for Tagrisso and the other for chemotherapy, which includes only those patients who had no skin cracking at mouth corners before treatment. The bar charts show the proportion of patients reporting severity of skin cracking at mouth corners at each time point through 24 weeks. For example, at week 2, 8% of patients taking Tagrisso reported skin cracking at mouth corners (ranging from mild to moderate).

All responses from patients who did not report Skin Cracking at Mouth Corners before treatment were included in the analysis. Some patients did not report their symptoms every week, therefore the number of patients may vary between weeks. Furthermore, not all patients remained on the treatment for 24 weeks (e.g., some stop treatment for worsening disease) which is a reason for the change in the number of patients over the course of treatment.

Worst Response Option for Skin Cracking at Mouth Corners That Patients Reported During the First 24 Weeks on Treatment, for Patients Who Did Not Have Skin Cracking at Mouth Corners Before Treatment:

Figure 4. Worst Patient-Reported Skin Cracking at Mouth Corners During the First 24 Weeks on Treatment: Patients Without Skin Cracking at Mouth Corners before treatment

Two pie charts, one for Tagrisso and the other for chemotherapy, which includes only those patients who had no skin cracking at mouth corners before treatment. The pie charts summarize the percentage of patients by worst reported skin cracking at mouth corners. In the Tagrisso arm, None (67%), Mild (25%), Moderate (7%), Severe (1%) and Very severe (0%). In the chemotherapy arm, None (53%), Mild (35%), Moderate (9%), Severe (0%) and Very severe (3%).

Patients who had no Skin Cracking at Mouth Corners before treatment and at least one on-treatment Skin Cracking at Mouth Corners score were included in the analysis. Tagrisso (N=69), Chemotherapy (N=43).